AGEING. WERNER SYNDROME AND PSEUDOCAPILLARIZATION

老化。

• 批准号: nhmrc : 570937
• 负责人: A/Pr Victoria Cogger
• 金额: $ 54.28万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/ageing-werner-syndrome-pseudocapillarization/80835
• 关键词: AGEING.; WERNER; SYNDROME; PSEUDOCAPILLARIZATION

Old age is the main risk factor for atherosclerosis, which is the main cause of mortality and morbidity in the World. We found age-related changes in the microcirculation of the liver called pseudocapillarization that provide a mechanism linking old age with atherosclerosis. Pores in the endothelium called fenestrations disappear, impairing the ability of the liver to breakdown fats. New therapies to treat and prevent age-related pseudocapillarization are being developed.

老年是动脉粥样硬化的主要危险因素，动脉粥样硬化是世界上死亡率和发病率的主要原因。我们发现了与年龄相关的肝脏微循环变化，称为假毛细血管化，它提供了一种将老年与动脉粥样硬化联系起来的机制。内皮细胞中称为开窗的小孔消失，损害了肝脏分解脂肪的能力。治疗和预防年龄相关性假性毛细血管化的新疗法正在开发中。