Effects of Ageing on Hepatic Drug Clearance and Mechanisms of Drug Induced Liver Disease

衰老对肝脏药物清除率的影响及药物性肝病的机制

• 批准号: nhmrc : 570968
• 负责人: A/Pr Victoria Cogger
• 金额: $ 38.8万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/effects-ageing-hepatic-liver-disease/98539
• 关键词: Effects; Ageing; Hepatic; Drug; Clearance

With increasing age, there is increase in disease, for which medications may provide benefit, and an increase in the risk of adverse drug reactions, even after considering the increase in medication use by older people. We will investigate how the liver clears drugs from the blood in old age. This will guide dosing of medications for older people. We will also study how drugs injure the liver in old age and test interventions to prevent this toxicity.

随着年龄的增长，疾病增加，药物可能提供益处，药物不良反应的风险增加，即使考虑到老年人使用药物的增加。我们将研究老年时肝脏如何清除血液中的药物。这将指导老年人的药物剂量。我们还将研究药物如何损害老年人的肝脏，并测试干预措施以防止这种毒性。