Molecular pathways linking nutrition and age-related health

连接营养和年龄相关健康的分子途径

• 批准号: nhmrc : 1101913
• 负责人: A/Pr Victoria Cogger
• 金额: $ 25.75万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-pathways-linking-related-health/662575
• 关键词: Molecular; pathways; linking; nutrition; age

Nutrition is the major modifiable factor that influences age-related health. Yet the relationships between nutrition, age-related health and underlying biological mechanisms are complex and poorly understood. We will tame this complexity by applying nutritional geometry and systems biology to nutrient sensing pathways and ageing phenotype across a macronutrient landscape. This will allow us to optimise diets and develop drugs to improve age-related health and extend healthspan.

营养是影响与年龄相关的健康的主要可改变因素。然而，营养、与年龄相关的健康和潜在的生物机制之间的关系是复杂的，人们对此知之甚少。我们将通过将营养几何学和系统生物学应用于营养传感途径和大量营养素景观中的衰老表型来驯服这种复杂性。这将使我们能够优化饮食，开发药物来改善与年龄相关的健康，延长健康寿命。