Training in Environmental Pathology

环境病理学培训

• 批准号: 6916381
• 负责人: Agnes B Kane
• 金额: $ 23.61万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6916381
• 关键词: Training; Environmental; Pathology

DESCRIPTION (provided by applicant) The objective of this interdisciplinary program is to educate a new generation of environmental pathologists to use the tools of cell biology, molecular biology, and biochemistry to study basic mechanisms of disease related to environmental and occupational exposures. The central focus is an independent laboratory research project to explore the pathogenesis of altered reproductive or immune function, neurodegenerative disease, or cancer resulting from exposure to reactive chemicals and oxidants, endocrine disrupting agents, metals, mineral fibers or stress. Pre-doctoral trainees will be recruited with majors in biology, chemistry, toxicology, or environmental sciences and commitment to basic research on mechanisms of disease. Postdoctoral trainees may hold doctoral degrees in a basic science discipline, pathology, or toxicology. All pre-doctoral trainees are required to learn the basic mechanisms and morphologic manifestations of disease in a general pathology course. Training is also provided in molecular pathology, imaging, genetic toxicology, immunopathology, environmental toxicology, epidemiology and biostatistics, carcinogenesis, and molecular genetics. All trainees will be instructed in the responsible conduct of research and will have the opportunity to develop their communication and teaching skills at the Sheridan Center for Teaching and Learning at Brown University. Didactic courses are supplemented by weekly research seminars, student journal clubs, career development workshops, and an annual Environmental Pathology Symposium. Strong emphasis is placed on communication skills, grantsmanship, interdisciplinary approaches, and implications of basic research on regulatory and public policy decisions. Continuing support is requested for four pre-doctoral and two postdoctoral trainees. The ten faculty have active, well-funded research programs ($2.5 million in annual direct costs) and access to modem research facilities equipped for quantitative imaging and morphometry, laser scanning confocal microscopy, laser capture microdissection, mass-spectroscopy, microarray analysis, flow cytometry, and transgenic animals.

描述（由申请人提供） 这个跨学科项目的目标是教育新的 一代环境病理学家使用细胞工具 生物学、分子生物学和生物化学研究基本机制 与环境和职业暴露有关的疾病。这 中心焦点是一个独立实验室研究项目，旨在探索 生殖或免疫功能改变的发病机制， 神经退行性疾病，或因暴露于反应性物质而导致的癌症 化学品和氧化剂、内分泌干扰剂、金属、矿物质 纤维或应力。将按专业招收博士前培训生 生物学、化学、毒理学或环境科学领域 致力于疾病机制的基础研究。博士后 学员可以拥有基础科学学科的博士学位， 病理学或毒理学。所有博士前培训生都必须 了解疾病的基本机制和形态学表现 一般病理学课程。还提供分子方面的培训 病理学、影像学、遗传毒理学、免疫病理学、环境学 毒理学、流行病学和生物统计学、致癌作用和 分子遗传学。所有受训者都将接受负责的指导 进行研究并将有机会发展他们的 谢里登教学中心的沟通和教学技能 和在布朗大学学习。教学课程补充为 每周研究研讨会、学生期刊俱乐部、职业发展 研讨会和年度环境病理学研讨会。强的 重点放在沟通技巧、资助能力、 跨学科方法以及基础研究的影响 监管和公共政策决策。请求持续支持 为四名博士前培训生和两名博士后培训生。十大师资队伍 拥有活跃且资金充足的研究项目（每年 250 万美元） 直接成本）和使用现代研究设施 定量成像和形态测定，激光扫描共焦 显微镜、激光捕获显微切割、质谱、微阵列 分析、流式细胞术和转基因动物。