Training in Environmental Pathology

描述(由申请人提供) 这个博士后和博士后培训项目的目标是教育新一代环境病理学家使用细胞生物学、分子生物学和生物化学的工具来研究与环境暴露有关的疾病的基本机制。中心重点是一个独立的实验室研究项目，旨在探索因接触工业废物和环境污染物(包括金属、塑化剂、杀虫剂、微粒和纤维)而导致的生殖功能改变、不良发育和妊娠结局、神经退行性疾病或癌症的发病机制。将招收生物、化学、毒理学或环境科学专业的博士前实习生，并致力于疾病机制和环境健康的基础研究。博士后实习生可以拥有基础科学学科、病理学或毒理学的博士学位。所有博士前实习生都需要学习人类疾病的基本机制和形态表现。还需要进行培训，以了解人类疾病的基本机制和形态表现。还提供了分子病理学、成像和环境毒理学、信号转导、癌症发生和分子遗传学方面的培训。所有受训人员将接受负责任的研究指导，并将有机会在布朗大学谢里丹教学中心发展他们的沟通和教学技能。授课课程还包括每周的研究研讨会、学生期刊俱乐部、职业发展研讨会和每年一次的环境病理学研讨会，重点放在沟通技能、资助力、跨学科方法以及基础研究对认识和预防人类疾病的影响上。为罗德岛医院和妇幼医院的临床和转化性研究合作提供机会，以及在罗德岛现有的工业废弃场和棕地进行实地工作和社区推广。这八名教员拥有资金充足的积极研究项目(每年直接成本为440万美元)，并可以使用现代研究设施，包括定量成像、激光捕获显微解剖、基因组和蛋白质组学、流式细胞术、转基因动物，以及获取人体组织和标本库。这些学员将准备将他们的基础研究专业知识应用于定义、分析和解决复杂的环境健康问题，与流行病学、毒理学、公共卫生以及政府和监管机构的专家合作。 背景 这项环境病理学培训计划是其第14年的支持，并集中在布朗大学生物和医学部的病理学和实验室医学系。该项目招募了8名教师作为导师，其中5人是医生，他们在肺、肝、生殖和神经健康领域拥有环境相关研究。这项研究的重点是环境因素和共同辅助因素造成的机械性、转化性和公共卫生后果。Agnes Kane博士、医学博士/博士自该计划开始以来一直担任主任，联合主任是Kim Boekelheide博士、医学博士/博士。该申请要求为5个博士后和2个博士后职位提供资金。 2005年招聘了一名新的院长，其任务是改善生物和医学系的研究生教育，这被认为是环境病理学培训方案的一项有利资产。2006年，培训方案招募了其最大的申请者群体。值得注意的是，该计划有超过400万美元的直接成本资金。博士前课程的一个重大变化是减少了必修课程和研讨会的数量，并将第一次研究轮换转到了第一学期。这一变动被认为是为了便利受训人员在第二学期结束时挑选论文研究导师，并便于受训人员在第二年末完成初步考试。该计划与受训者进行了多项互动活动，以解决负责任的研究行为。针对通过内部和外部审查收到的反馈，代表不同职业道路的特邀演讲者人数有所增加。 这项申请寻求持续支持(16-20年)在布朗大学病理生物学研究生课程内的环境病理学轨道的培训。这个项目是生物和医学分部和环境研究中心的一部分。在续签申请中，有8名教官被点名，低于2001年的10名。

DESCRIPTION (provided by applicant) The objective of this predoctoral and postdoctoral training program is to educate a new generation of environmental pathologists to use the tools of cell biology, molecular biology, and biochemistry to study basic mechanisms of disease related to environmental exposures. The central focus is an independent laboratory research project to explore the pathogenesis of altered reproductive function, adverse developmental and pregnancy outcomes, neurodegenerative disease, or cancer resulting from exposure to industrial wastes and environmental contaminants including metals, plasticizers, pesticide, particulates and fibers. Predoctoral trainees will be recruited with majors in biology, chemistry, toxicology, or environmental sciences and a commitment to basic research on mechanism of disease and environmental health. Postdoctoral trainees may hold a doctoral degree in a basic science discipline, pathology, or toxicology. All predoctoral trainees are required to learn the basic mechanisms and morphologic manifestations of human disease. Training is also required to learn the basic mechanisms and morphologic manifestations of human disease. Training is also provided in molecular pathology, imaging, and environmental toxicology, signal transduction, carcinogenesis, and molecular genetics. All trainees will be instructed in the responsible conduct of research and will have the opportunity to develop their communication and teaching skills at the Sheridan Center for Teaching and Learning at Brown University. Didactic courses are supplemented by weekly research seminars, student journal clubs, career development workshops, and an annual Environmental Pathology Symposium, Strong emphasis is placed on communication skills, grantsmanship, interdisciplinary approaches, and implications of basic research for recognition and prevention of human disease. Opportunities are provided for clinical and translational research collaborations at Rhode Island Hospital and Women & Infants' Hospital, as well as field work and community outreach at existing industrial waste sites and Brownfields in Rhode Island. The eight faculty have active, well-funded research programs ($4.4 million in annual direct costs) and access to modern research facilities equipped for quantitative imaging, laser capture microdissection, genomics and proteomics, flow cytometry, transgenic animals, and access to human tissue and specimen banks. These trainees will be prepared to apply their basic research expertise to the definition, analysis, and solution of complex environmental health problems working together with experts in epidemiology, toxicology, public health, and government and regulatory agencies. BACKGROUND This Training in Environmental Pathology program is in its 14th year of support and is centered in the department of Pathology and Laboratory Medicine in the Division of Biology and Medicine at Brown University. The program enlists eight faculty, five of which are physicians, as mentors that have environmental related research in the areas of pulmonary, hepatic, reproductive and neurological health. The research focuses on mechanistic, translational and public health outcomes from environmental agents and common cofactors. Dr. Agnes Kane MD/PhD has acted as Director of the program since its inception and the Co-Director is Dr. Kim Boekelheide MD/PhD. The application requests funding for five predoctoral and two postdoctoral positions. Recruitment of a new Dean in 2005 with a strong mandate to improve graduate education in the Division of Biology and Medicine was considered an advantageous asset to the Environmental Pathology Training Program. In 2006 the Training Program recruited its largest applicant pool. It was noteworthy that the program has over $4 million in direct cost funding. A major change in the predoctoral curriculum was a reduction in the number of required courses and seminars and transfer of the first research rotation to the first semester. This change was considered to facilitate the trainee's selection of a thesis research mentor at the end of the second semester and to facilitate the trainee's progression to completion of the preliminary examination at the end of the second year. The program has multiple interactive activities with trainees to address the responsible conduct of research. In response to feedback received via internal and external reviews the number of invited speakers representing diverse career pathways has been increased. This application seeks continuing support (years 16-20) for training in the environmental pathology track within the Pathobiology Graduate Program at Brown University. This program is part of the Division of Biology and Medicine and Center for Environmental Studies. Eight preceptors are named in the renewal application, down from ten named in 2001.