Prophylactic colectomy intentions in HNPCC patients
HNPCC 患者的预防性结肠切除术意图
基本信息
- 批准号:6804133
- 负责人:
- 金额:$ 8.43万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2003
- 资助国家:美国
- 起止时间:2003-09-26 至 2006-11-30
- 项目状态:已结题
- 来源:
- 关键词:anxietybehavior predictionbehavioral /social science research tagcancer preventioncancer riskclinical researchcolon surgerycolorectal neoplasmscounselingdecision makingendoscopygastrointestinal imaging /visualizationgenetic carriersgenetic susceptibilityhealth educationhuman datahuman subjectinterviewneoplasm /cancer geneticspreferencepsychological aspect of cancerpsychological modelsquality of lifesocial psychologythinking
项目摘要
DESCRIPTION (provided by applicant):
Hereditary non-polyposis colorectal cancer (HNPCC) is associated with up to an 80 percent lifetime risk of developing colorectal cancer and a 40 to 50 percent chance of a metachronous tumor after partial colectomy for the disease. For these patients, prophylactic colectomy has been proposed as a potential risk management alternative to a lifetime of intensive surveillance by colonoscopy. The highly personal nature of risk management decisions has been recognized in the development of individualized genetic counseling services. However, prior psychosocial research in this area has tended to use linear statistical techniques in which clinically important details are lost in an overly broad, one-size-fits-all model that is difficult to apply in a one-to-one counseling session. We propose an innovative approach based on the Cognitive-Social Health Information Processing (C-SHIP) model in which we will explore how these factors are organized into meaningful patterns or types that can translate readily into tailored counseling recommendations. Specific aims of this study are: 1)To assess levels of interest in prophylactic colectomy among HNPCC patients; 2) To identify distinctive decision types based on profiles of perceived pros and cons of prophylactic colectomy; and 3) To explore the pattern of relations between decision types and counseling-related outcomes (level of interest in colectomy, cancer-specific anxiety, and colonoscopy adherence). We will conduct a one-time cross-sectional telephone survey of 320 HNPCC patients (defined as either carriers of a mutated mismatch repair gene associated with HNPCC or those with a personal or family history meeting published criteria for HNPCC). Using cluster analysis we will create a taxonomy of decision types. Prior research leads us to expect at least three types: Disengaged, Risk-Focused, and Ambivalent. We hypothesize that each type will have a different pattern of relations with the outcome variables (e.g., Risk-focused types will show high interest in surgery, high anxiety, low avoidance, and high colonoscopy adherence, whereas Ambivalent types will show high interest in surgery, high anxiety, high avoidance, and low colonoscopy adherence). Understanding these patterns will enhance the ability of physicians, genetic counselors, and other providers to help their patients make well-informed, thoughtful decisions about the preventive strategy that will best protect their health, emotional well-being, and quality of life.
描述(由申请人提供):
遗传性非息肉病性结直肠癌(HNPCC)与高达80%的终生结直肠癌风险相关,并且在部分结肠切除术后发生异时性肿瘤的可能性为40%至50%。对于这些患者,预防性结肠切除术已被提出作为一个潜在的风险管理替代终身强化监测结肠镜检查。风险管理决策的高度个人化性质在个体化遗传咨询服务的发展中得到了认可。然而,在这一领域之前的心理社会研究倾向于使用线性统计技术,其中临床上重要的细节丢失在一个过于广泛的,一刀切的模型中,难以应用于一对一的咨询会议。我们提出了一种基于认知-社会健康信息处理(C-SHIP)模型的创新方法,我们将探索这些因素如何被组织成有意义的模式或类型,这些模式或类型可以很容易地转化为量身定制的咨询建议。本研究的具体目的是:1)评估HNPCC患者对预防性结肠切除术的兴趣水平; 2)根据预防性结肠切除术的利弊来识别不同的决策类型; 3)探索决策类型与咨询相关结果(结肠切除术的兴趣水平,癌症特异性焦虑和结肠镜检查依从性)之间的关系模式。我们将对320例HNPCC患者(定义为与HNPCC相关的突变错配修复基因的携带者或具有符合HNPCC公布标准的个人或家族史的患者)进行一次性横断面电话调查。使用聚类分析,我们将创建决策类型的分类。先前的研究让我们至少期待三种类型:脱离,风险集中和矛盾。我们假设每种类型与结果变量的关系模式不同(例如,关注风险的类型将表现出对手术的高兴趣、高焦虑、低回避和高结肠镜依从性,而矛盾型将表现出对手术的高兴趣、高焦虑、高回避和低结肠镜依从性。了解这些模式将提高医生,遗传咨询师和其他提供者的能力,以帮助他们的病人做出明智的,深思熟虑的预防策略,这将最好地保护他们的健康,情感幸福和生活质量的决定。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
KAREN E HURLEY其他文献
KAREN E HURLEY的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('KAREN E HURLEY', 18)}}的其他基金
MULTIPLE RISKS, DECISIONS & BEHAVIORS IN THE GENOMIC ERA
多重风险、决策
- 批准号:
7883230 - 财政年份:2006
- 资助金额:
$ 8.43万 - 项目类别:
MULTIPLE RISKS, DECISIONS & BEHAVIORS IN THE GENOMIC ERA
多重风险、决策
- 批准号:
7037226 - 财政年份:2006
- 资助金额:
$ 8.43万 - 项目类别:
MULTIPLE RISKS, DECISIONS & BEHAVIORS IN THE GENOMIC ERA
多重风险、决策
- 批准号:
7683728 - 财政年份:2006
- 资助金额:
$ 8.43万 - 项目类别:
MULTIPLE RISKS, DECISIONS & BEHAVIORS IN THE GENOMIC ERA
多重风险、决策
- 批准号:
7495505 - 财政年份:2006
- 资助金额:
$ 8.43万 - 项目类别:
MULTIPLE RISKS, DECISIONS & BEHAVIORS IN THE GENOMIC ERA
多重风险、决策
- 批准号:
7261371 - 财政年份:2006
- 资助金额:
$ 8.43万 - 项目类别:
Prophylactic colectomy intentions in HNPCC patients
HNPCC 患者的预防性结肠切除术意图
- 批准号:
6743497 - 财政年份:2003
- 资助金额:
$ 8.43万 - 项目类别:
相似海外基金
Construction of a learning support system through learning behavior prediction using student modeling
使用学生建模通过学习行为预测构建学习支持系统
- 批准号:
23K17604 - 财政年份:2023
- 资助金额:
$ 8.43万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
Development of Service Process Measurement System based on Behavior Prediction in Nursing-care Service
基于行为预测的护理服务过程测量系统开发
- 批准号:
22K12286 - 财政年份:2022
- 资助金额:
$ 8.43万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Collaborative Research: IMR: MM-1C: Privacy-preserving IoT Analytics and Behavior Prediction on Network Edge
合作研究:IMR:MM-1C:网络边缘上的隐私保护物联网分析和行为预测
- 批准号:
2219866 - 财政年份:2022
- 资助金额:
$ 8.43万 - 项目类别:
Standard Grant
Collaborative Research: IMR: MM-1C: Privacy-preserving IoT Analytics and Behavior Prediction on Network Edge
合作研究:IMR:MM-1C:网络边缘上的隐私保护物联网分析和行为预测
- 批准号:
2219867 - 财政年份:2022
- 资助金额:
$ 8.43万 - 项目类别:
Standard Grant
Object State Change Detection and Human Behavior Prediction Focused on Hand Manipulation
专注于手部操作的物体状态变化检测和人类行为预测
- 批准号:
21J11626 - 财政年份:2021
- 资助金额:
$ 8.43万 - 项目类别:
Grant-in-Aid for JSPS Fellows
Collaborative Research: RI: Medium: Learning Joint Crowd-Space Embeddings for Cross-Modal Crowd Behavior Prediction
合作研究:RI:Medium:学习联合人群空间嵌入以进行跨模式人群行为预测
- 批准号:
1955365 - 财政年份:2020
- 资助金额:
$ 8.43万 - 项目类别:
Standard Grant
Collaborative Research: RI: Medium: Learning Joint Crowd-Space Embeddings for Cross-Modal Crowd Behavior Prediction
合作研究:RI:Medium:学习联合人群空间嵌入以进行跨模式人群行为预测
- 批准号:
1955404 - 财政年份:2020
- 资助金额:
$ 8.43万 - 项目类别:
Standard Grant
Behavior Prediction of Traffic Participants based on Micro and Macro features for Urban Automated Driving
城市自动驾驶基于微观和宏观特征的交通参与者行为预测
- 批准号:
20K04397 - 财政年份:2020
- 资助金额:
$ 8.43万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
CAREER: Towards Fatigue Behavior Prediction of Structural Materials through Computationally-Informed Textural and Microstructural Characteristics
职业:通过计算信息的纹理和微观结构特征预测结构材料的疲劳行为
- 批准号:
1751591 - 财政年份:2018
- 资助金额:
$ 8.43万 - 项目类别:
Standard Grant
Research on Behavior Prediction of Cylindrical Line Structure with Rotation in Flow
流动中旋转圆柱线结构行为预测研究
- 批准号:
18H01634 - 财政年份:2018
- 资助金额:
$ 8.43万 - 项目类别:
Grant-in-Aid for Scientific Research (B)