Mechanisms and Effects of Chiropractic Manipulation

帕尔默脊椎按摩研究中心 (PCCR) 提议建立一个为期 3 年的多学科发展中心，研究脊椎按摩的机制和效果（中心），以提高正在进行的研究项目的水平和质量，推进科学专业知识和研究基础设施，并支持帕尔默脊椎按摩大学、爱荷华大学、堪萨斯州立大学、纽约州立大学和国立健康科学大学的 12 名研究人员之间加强沟通和合作。该中心将促进 4 个协同研究项目。该中心的中心科学主题是 专注于脊柱推拿 (SM)、腰痛 (LBP) 以及 SM 的作用机制。长期目标是探索和了解 SM 的临床作用以及 SM 负荷的生理和生物力学机制。项目 1 将使用动物模型研究椎骨负载对小关节囊的生物力学和神经学影响。项目 2 将研究 SM 在大鼠脊柱固定模型中的行为、生物力学和生物效应。项目 3 将探索预测 SM 对 LBP 患者的重要临床效果的变量，检查接受 SM 的患者生物力学和生理功能的变化，并从生物力学上表征 SM 的 2 种形式。项目 4 将在动物模型中研究椎骨负荷对交感神经调节的影响。项目将得到数据管理和生物统计核心、生物力学核心和管理核心的支持。研究人员将使用试点数据向 NIH 提交竞争性资助申请，并将为未来的 CAM 研究人员提供研究培训经验。该发展中心将建立并扩展 NIH 支持的 PCCR 脊椎按摩研究联合中心近期的成功历史。它将提供重点和方向，以协同增加人员和资源的“临界质量”，以满足重要的未满足的公共卫生需求。

Palmer Center for Chiropractic Research (PCCR) proposes to establish a 3 year multidisciplinary Developmental Center for the Study of Mechanisms and Effects of Chiropractic Manipulation (Center) to increase the level and quality of the ongoing research program, to advance scientific expertise and research infrastructure, and to support enhanced communication and partnering among 12 investigators at Palmer Chiropractic University, the University of Iowa, Kansas State University, State University of New York, and National University of Health Sciences. The Center will facilitate 4 synergistic research projects. The central scientific theme of the Center is focused on spinal manipulation (SM), low back pain (LBP), and the mechanisms of action of SM. The long range goal is to explore and understand the clinical role of SM and the physiological and biomechanical mechanisms of SM loads. Project 1 will study the biomechanical and neurological effects of vertebral loading on the facet joint capsule using an animal model. Project 2 will study the behavioral, biomechanical and biological effects of SM in a rat spine fixation model. Project 3 will explore variables that predict an important clinical effect of SM in patients with LBP, examine changes in biomechanical and physiological functions of patients undergoing SM, and biomechanically characterize 2 forms of SM. Project 4 will study the effect of vertebral loading on sympathetic nerve regulation in an animal model. Projects will be supported by the Data Management and Biostatistics Core, the Biomechanics Core and the Administration Core. Investigators will use pilot data to submit competitive grant applications to NIH, and will provide research training experiences for future CAM investigators. The developmental Center will build on and extend the successful recent history of the NIH supported, Consortial Center for Chiropractic Research at PCCR. It will provide the focus and direction to synergistically increase the "critical mass" of personnel and resources to address an important unmet public health need.