Mechanisms and Effects of Chiropractic Manipulation

帕尔默脊椎按摩研究中心(PCCR)建议建立一个为期3年的多学科脊椎手法机制和效果研究发展中心(CENTER)，以提高正在进行的研究计划的水平和质量，提升科学专长和研究基础设施，并支持帕尔默脊椎按摩大学、爱荷华大学、堪萨斯州立大学、纽约州立大学和国立健康科学大学的12名研究人员之间加强沟通和合作。中心将为4个协同研究项目提供便利。该中心的中心科学主题是 重点介绍了脊柱手法、下腰痛及其作用机制。长期目标是探索和了解SM的临床作用以及SM负荷的生理和生物力学机制。项目1将使用动物模型研究椎体负荷对小关节囊的生物力学和神经学影响。项目2将在大鼠脊柱固定模型上研究SM的行为、生物力学和生物学效应。项目3将探索预测SM在LBP患者中的重要临床效果的变量，检查SM患者的生物力学和生理功能的变化，并从生物力学的角度描述SM的两种形式。项目4将在动物模型中研究椎骨负荷对交感神经调节的影响。项目将得到数据管理和生物统计核心、生物力学核心和行政核心的支持。研究人员将使用试点数据向NIH提交竞争性拨款申请，并将为未来的CAM调查人员提供研究培训经验。该发展中心将在PCCR由美国国立卫生研究院支持的脊椎疗法研究联盟中心的成功近期历史的基础上发展和扩展。它将提供重点和方向，协同增加“临界数量”的人员和资源，以满足一个重要的、未得到满足的公共卫生需求。

Palmer Center for Chiropractic Research (PCCR) proposes to establish a 3 year multidisciplinary Developmental Center for the Study of Mechanisms and Effects of Chiropractic Manipulation (Center) to increase the level and quality of the ongoing research program, to advance scientific expertise and research infrastructure, and to support enhanced communication and partnering among 12 investigators at Palmer Chiropractic University, the University of Iowa, Kansas State University, State University of New York, and National University of Health Sciences. The Center will facilitate 4 synergistic research projects. The central scientific theme of the Center is focused on spinal manipulation (SM), low back pain (LBP), and the mechanisms of action of SM. The long range goal is to explore and understand the clinical role of SM and the physiological and biomechanical mechanisms of SM loads. Project 1 will study the biomechanical and neurological effects of vertebral loading on the facet joint capsule using an animal model. Project 2 will study the behavioral, biomechanical and biological effects of SM in a rat spine fixation model. Project 3 will explore variables that predict an important clinical effect of SM in patients with LBP, examine changes in biomechanical and physiological functions of patients undergoing SM, and biomechanically characterize 2 forms of SM. Project 4 will study the effect of vertebral loading on sympathetic nerve regulation in an animal model. Projects will be supported by the Data Management and Biostatistics Core, the Biomechanics Core and the Administration Core. Investigators will use pilot data to submit competitive grant applications to NIH, and will provide research training experiences for future CAM investigators. The developmental Center will build on and extend the successful recent history of the NIH supported, Consortial Center for Chiropractic Research at PCCR. It will provide the focus and direction to synergistically increase the "critical mass" of personnel and resources to address an important unmet public health need.