Clinical Research Center for the Improved Prevention, Diagnosis, and Treatment of Vocal Hyperfunction

声乐功能亢进预防、诊断和治疗临床研究中心

• 批准号: 9898345
• 负责人: Robert E Hillman
• 金额: $ 223.42万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9898345
• 关键词: Acoustics; Address; Arousal; Auditory; Behavior Therapy; Behavioral; Benign; Biofeedback; Biomechanics; Biosensor; Chronic; Classification; Clinic; Clinical; Clinical Data; Clinical Management; Clinical Research; Computer Models; Diagnosis; Differential Diagnosis; Disease; Disease Management; Dysphonia; Emotional; Etiology; Feedback; Functional disorder; Future; Genetic; Goals; Individual; Interdisciplinary Study; Investigation; Knowledge; Laboratory Study; Lesion; Link; Methods; Modeling; Morphology; Motor; Muscle; Muscle Tension; Neural Network Simulation; Nodule; Noise; Output; Participant; Pathology; Patients; Phenotype; Physiological; Play; Polyps; Predisposing Factor; Prevention; Psychological Stress; Research; Research Personnel; Research Project Grants; Risk; Role; Solid; Speech; Structure; Sum; Testing; Translating; Voice; Voice Disorders; Work; base; cohesion; daily functioning; design; direct application; experience; improved; innovation; insight; motor control; multidisciplinary; physical model; programs; psychologic; recruit; sound; treatment strategy; vocal cord

Project Summary/Abstract Vocal hyperfunction (VH) is associated with the most frequently occurring types of voice disorders. These include benign vocal folds lesions (e.g., nodules and polyps) and dysphonia that occurs in the absence of concurrent pathology (e.g., muscle tension dysphonia). Effective prevention and clinical management of these disorders continue to be hampered by limited knowledge of the etiological and pathophysiological mechanisms that underlie specific voice disorders within the broad range of those associated with VH. To address this need, this Clinical Research Center brings together a multidisciplinary team of experienced investigators to pursue a comprehensive program of research focused on hyperfunctional voice disorders. The central theme of the Center is that the clinical management of hyperfunctional voice disorders can be significantly improved by attaining a better understanding of the etiology and pathophysiology of these disorders and then translating this knowledge into new, more effective methods for prevention, diagnosis, and treatment. A central premise of this work is that multiple factors contribute and interact in different ways to cause and maintain the various disorders linked to VH, with the most important being associated with behavioral, sensorimotor, environmental, psychological/emotional, physiological, and biomechanical mechanisms. The interdisciplinary research program will focus on attaining a comprehensive understanding of the fundamental relationships between these factors and the different manifestations of VH. Research at the Center will be guided and coordinated by a new comprehensive theoretical framework for VH that clearly illustrates the key hypotheses that will be assessed in a combined effort by the three major Research Projects and Scientific Core that comprise the Center. The Center’s Projects will employ an innovative combination of laboratory studies of sensorimotor and physiologic mechanisms; neural network modeling of voice motor control; computational and physical modeling of phonatory mechanisms; and the use of ambulatory biosensors to investigate the potential differential impact on vocal function of daily voice use, psychological stress, and environmental sound level in patients with VH and well-matched normal controls. Use of ambulatory biofeedback as a treatment strategy will also be assessed. A significant strength of the Center will be the centralized recruitment and clinical management of all participants through the Scientific Core, which will greatly facilitate the integration of results across the projects and magnify the impact of the Center well beyond the sum of its parts. This program of research in hyperfunctional voice disorders is unprecedented in terms of its scope, integration of information across multiple domains, number of innovative concepts and methods that are being simultaneously developed and tested, and its potential to significantly improve the clinical management of these disorders. Achieving the goals of this research program will lead to improved prevention, differential diagnosis, and more focused and efficient treatment of these very prevalent conditions.

项目总结/摘要 发声功能亢进（VH）与最常见的嗓音障碍类型有关。这些 包括良性声带病变（例如，结节和息肉）和发音困难，发生在没有 并发病理（例如，肌肉紧张性发音困难）。有效预防和临床管理这些 疾病继续受到病因学和病理生理学机制的有限知识的阻碍 在与VH相关的广泛范围内的特定语音障碍的基础。为了满足这一需求， 该临床研究中心汇集了一个由经验丰富的研究人员组成的多学科团队， 一个专注于功能亢进性嗓音障碍的综合性研究项目。的中心主题 中心是，临床管理的功能亢进的声音障碍，可以显着改善， 更好地理解这些疾病的病因和病理生理学， 这些知识转化为新的、更有效的预防、诊断和治疗方法。 这项工作的一个中心前提是，多种因素以不同的方式促成和相互作用， 维持与VH相关的各种疾病，最重要的是与行为相关， 感觉运动、环境、心理/情感、生理和生物力学机制。的 跨学科的研究计划将侧重于实现基本的全面了解 这些因素与VH不同表现之间的关系。研究中心将在 在一个新的全面的VH理论框架的指导和协调下， 这些假设将由三个主要研究项目和科学研究项目共同评估。 核心组成了中心。该中心的项目将采用创新的实验室组合， 感觉运动和生理机制的研究;语音运动控制的神经网络建模; 发声机制的计算和物理建模;以及使用流动生物传感器， 调查日常发声、心理压力对发声功能的潜在差异影响， VH患者和匹配良好的正常对照组的环境噪声水平。使用门诊 生物反馈作为一种治疗策略也将得到评估。该中心的一个重要优势将是 通过科学核心集中招募和临床管理所有参与者， 极大地促进了跨项目成果的整合，并扩大了中心的影响， 各部分的总和 这项研究计划在功能亢进的声音障碍是前所未有的，其范围，整合 跨多个领域的信息，许多创新的概念和方法， 同时开发和测试，其潜力显着改善临床管理， 这些紊乱。实现这一研究计划的目标将导致改善预防， 诊断，以及对这些非常普遍的疾病进行更集中和有效的治疗。