Clinical Research Center for the Improved Prevention, Diagnosis, and Treatment of Vocal Hyperfunction

声乐功能亢进预防、诊断和治疗临床研究中心

• 批准号: 10639609
• 负责人: Robert E Hillman
• 金额: $ 299万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-15 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10639609
• 关键词: Address; Ambulatory Monitoring; Applications Grants; Arousal; Auditory; Behavior Therapy; Behavioral; Benign; Biofeedback; Biomechanics; Categories; Classification; Clinic; Clinical; Clinical Management; Clinical Research; Clinical Trials; Computer Models; Data; Data Science Core; Databases; Detection; Diagnosis; Differential Diagnosis; Dimensions; Disease; Disease Management; Disparate; Dysphonia; Emotional; Etiology; Functional disorder; Funding; Goals; Grant; Interdisciplinary Study; Investigation; Knowledge; Laboratory Study; Larynx; Lesion; Life; Link; Measurement; Measures; Methods; Monitor; Motor; Muscle Tension; Musculoskeletal; Nodule; Pathology; Patients; Phenotype; Phonation; Physiological; Polyps; Predisposing Factor; Prevention; Productivity; Psychometrics; Randomized Controlled Clinical Trials; Research; Research Personnel; Research Project Grants; Role; Solid; Source; Structure; Sum; Technology; Testing; Therapeutic; Training; Translating; Validation; Voice; Voice Disorders; Work; biomechanical model; clinical translation; design; endophenotype; evidence base; experience; human data; improved; innovation; insight; motor control; multidisciplinary; neuroregulation; novel; participant enrollment; physical model; programs; psychologic; vocal cord; voice therapy

Project Summary/Abstract Vocal hyperfunction (VH) is associated with the most frequently occurring types of voice disorders. These include benign vocal folds lesions (e.g., nodules and polyps) and dysphonia that occurs in the absence of concurrent pathology (e.g., muscle tension dysphonia). Effective prevention and clinical management of these disorders continue to be hampered by limited knowledge of the etiological and pathophysiological mechanisms that underlie specific voice disorders within the broad range of those associated with VH. To address this need, this Clinical Research Center brings together a multidisciplinary team of experienced investigators to pursue a comprehensive program of research focused on hyperfunctional voice disorders. The central theme of the Center is that the clinical management of hyperfunctional voice disorders can be significantly improved by attaining a better understanding of the etiology and pathophysiology of these disorders and then translating this knowledge into new, more effective methods for prevention, diagnosis, and treatment. A central premise of this work is that multiple factors contribute and interact in different ways to cause and maintain the various disorders linked to VH. The most important are associated with behavioral, sensorimotor, environmental, psychological/emotional, physiological, and biomechanical mechanisms. The interdisciplinary research program will focus on attaining a comprehensive understanding of the fundamental relationships between these factors and the different manifestations of VH. Research at the Center is guided and coordinated by a comprehensive theoretical framework for VH that clearly illustrates the key hypotheses that will be assessed in a coordinated effort overseen by an Administrative Core and carried out by the four Research Projects and Technology and Data Science Core. Projects will employ an innovative combination of laboratory studies of sensorimotor and physiological mechanisms; physical and computational modeling of biomechanical, aero- acoustic, and auditory-motor control mechanisms; and the use of improved ambulatory voice monitoring technology to investigate potential etiological and pathophysiological mechanisms of VH associated with daily voice use. A clinical trial will also assess the benefit of combining novel ambulatory biofeedback with evidence- based voice therapy to treat VH. A significant strength of the Center will be a centralized multidimensional database in the Technology and Data Science Core that receives comprehensive data from all of the projects for all enrolled patients and healthy controls, thus greatly facilitating the integration of results across the projects and magnifying the impact of the Center well beyond the sum of its parts. This program of research in hyperfunctional voice disorders is unprecedented in terms of its scope, integration of information across multiple domains, number of innovative concepts, and methods that are being simultaneously developed and tested. Achieving the goals of this research program will significantly improve the prevention and clinical management of these highly prevalent disorders.

项目总结/摘要 发声功能亢进（VH）与最常见的嗓音障碍类型有关。这些包括 良性声带病变（例如，结节和息肉）和发音困难，发生在没有并发 病理学（例如，肌肉紧张性发音困难）。有效预防和临床管理这些疾病 继续受到对病因学和病理生理学机制的有限认识的阻碍， 在与VH相关的广泛范围内的特定语音障碍的基础。为了满足这一需求， 临床研究中心汇集了经验丰富的研究人员组成的多学科团队， 一个专注于功能亢进性嗓音障碍的综合性研究项目。中心的中心主题 通过获得一个有效的治疗方法， 更好地了解这些疾病的病因和病理生理学，然后将这些知识转化为 新的、更有效的预防、诊断和治疗方法。 这项工作的一个中心前提是，多种因素以不同的方式促成和相互作用， 维持与VH相关的各种疾病。最重要的是与行为，感觉运动， 环境、心理/情感、生理和生物力学机制。跨学科 研究计划将侧重于全面了解基本关系 这些因素与VH的不同表现之间的关系。该中心的研究得到指导和协调 通过一个全面的理论框架，清晰地说明了关键假设，将评估 在一个协调的努力，由一个行政核心监督，并通过四个研究项目进行， 技术和数据科学核心。项目将采用实验室研究的创新组合， 感觉运动和生理机制;生物力学、空气动力学、 听觉和听觉运动控制机制;以及使用改进的动态语音监测 研究与日常饮食相关的VH的潜在病因学和病理生理学机制的技术 语音使用。一项临床试验也将评估将新型动态生物反馈与证据相结合的益处- 基于语音治疗来治疗VH。该中心的一个重要优势将是一个集中的多层面 技术和数据科学核心中的数据库，接收来自所有项目的综合数据 对于所有入组患者和健康对照，从而极大地促进了跨项目结果的整合 并扩大该中心的影响远远超过其各部分的总和。 这项研究计划在功能亢进的声音障碍是前所未有的，其范围，整合 跨多个领域的信息，创新概念的数量和方法， 同时开发和测试。实现这项研究计划的目标将大大提高 预防和临床管理这些高度流行的疾病。