Clinical Research Center for the Improved Prevention, Diagnosis, and Treatment of Vocal Hyperfunction

项目摘要/摘要 发声功能亢进(VH)与最常见的发音障碍类型有关。这些措施包括 良性声带病变(如小结和息肉)和发音困难，在没有并发的情况下发生 病理学(如肌肉紧张性发音困难)。这些疾病的有效预防和临床治疗 继续受到对病因和病理生理机制的有限了解的阻碍 在与VH相关的广泛范围内，特定的嗓音障碍是潜在的。为了满足这一需求，这 临床研究中心汇集了一支由经验丰富的研究人员组成的多学科团队，以追求 全面的研究计划侧重于功能亢进性嗓音障碍。中心的中心主题 是通过获得一种有效的治疗方法，可以显著改善功能性发声障碍的临床治疗 更好地理解这些疾病的病因和病理生理学，然后将这些知识转化为 为预防、诊断和治疗提供新的、更有效的方法。 这项工作的一个中心前提是，多种因素以不同的方式贡献和相互作用，导致和 保持与VH相关的各种紊乱。最重要的是与行为、感觉运动、 环境、心理/情绪、生理和生物力学机制。跨学科 研究计划将重点放在全面了解基本关系 在这些因素与VH的不同表现之间。该中心的研究受到指导和协调 通过一个全面的VH理论框架，清楚地说明将评估的关键假设 在一个行政核心的监督下，由四个研究项目和 技术和数据科学核心。项目将采用创新的实验室研究组合 感觉运动和生理机制；生物力学、空气动力学和生物力学的物理和计算模型 声学和听觉运动控制机制；以及使用改进的动态语音监测 研究与日常生活相关的VH的潜在病因和病理生理学机制的技术 语音使用。一项临床试验还将评估将新的动态生物反馈与证据相结合的好处。 以声音疗法为基础治疗VH。该中心的一个重要优势将是集中式多维 技术和数据科学核心数据库，接收所有项目的综合数据 用于所有登记的患者和健康对照，从而极大地促进了项目结果的整合 并将中心的影响放大到远远超过其各部分之和的地步。 这个研究多动症发声障碍的项目在其范围、集成度方面都是前所未有的 跨多个领域的信息、许多创新的概念和方法 同时进行开发和测试。实现这一研究计划的目标将显著提高 预防和临床处理这些高度流行的疾病。

Project Summary/Abstract Vocal hyperfunction (VH) is associated with the most frequently occurring types of voice disorders. These include benign vocal folds lesions (e.g., nodules and polyps) and dysphonia that occurs in the absence of concurrent pathology (e.g., muscle tension dysphonia). Effective prevention and clinical management of these disorders continue to be hampered by limited knowledge of the etiological and pathophysiological mechanisms that underlie specific voice disorders within the broad range of those associated with VH. To address this need, this Clinical Research Center brings together a multidisciplinary team of experienced investigators to pursue a comprehensive program of research focused on hyperfunctional voice disorders. The central theme of the Center is that the clinical management of hyperfunctional voice disorders can be significantly improved by attaining a better understanding of the etiology and pathophysiology of these disorders and then translating this knowledge into new, more effective methods for prevention, diagnosis, and treatment. A central premise of this work is that multiple factors contribute and interact in different ways to cause and maintain the various disorders linked to VH. The most important are associated with behavioral, sensorimotor, environmental, psychological/emotional, physiological, and biomechanical mechanisms. The interdisciplinary research program will focus on attaining a comprehensive understanding of the fundamental relationships between these factors and the different manifestations of VH. Research at the Center is guided and coordinated by a comprehensive theoretical framework for VH that clearly illustrates the key hypotheses that will be assessed in a coordinated effort overseen by an Administrative Core and carried out by the four Research Projects and Technology and Data Science Core. Projects will employ an innovative combination of laboratory studies of sensorimotor and physiological mechanisms; physical and computational modeling of biomechanical, aero- acoustic, and auditory-motor control mechanisms; and the use of improved ambulatory voice monitoring technology to investigate potential etiological and pathophysiological mechanisms of VH associated with daily voice use. A clinical trial will also assess the benefit of combining novel ambulatory biofeedback with evidence- based voice therapy to treat VH. A significant strength of the Center will be a centralized multidimensional database in the Technology and Data Science Core that receives comprehensive data from all of the projects for all enrolled patients and healthy controls, thus greatly facilitating the integration of results across the projects and magnifying the impact of the Center well beyond the sum of its parts. This program of research in hyperfunctional voice disorders is unprecedented in terms of its scope, integration of information across multiple domains, number of innovative concepts, and methods that are being simultaneously developed and tested. Achieving the goals of this research program will significantly improve the prevention and clinical management of these highly prevalent disorders.