Next generation micro CT

下一代显微 CT

基本信息

  • 批准号:
    6936254
  • 负责人:
  • 金额:
    $ 9.36万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2005
  • 资助国家:
    美国
  • 起止时间:
    2005-09-30 至 2006-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Commercially available micro-CT (computer tomography) systems have failed to meet the challenging demands for small animal imaging, beyond the single requirement for good spatial resolution. Specifically, they have failed to take into account that the thousand times smaller volume in mice, compared to humans, is also coupled with 10 times faster heart rates, and increased respiratory rates and circulation times. Thus, the currently available systems have been limited to either: (1) in-vivo volume CT, which is primarily useful for co-registration of anatomical with functional images provided by positron emission tomography (PET) or single photon emission computer tomography (SPECT), but is very slow (several minutes); or (2) ex-vivo high spatial resolution CT, with good contrast resolution for specimen imaging but at too high dose for live subjects. Thus, these commercial systems all fail to address significant applications for micro-CT, such as tumor perfusion and cardiac ejection fraction studies. The goal of this project is to develop a next generation micro-CT for pre-clinical imaging for drug development and medical research. The system will be designed to provide clinical quality CT images in vivo in mice and rats, with performance specifications optimized to accommodate the demanding requirements of the most critical areas currently in medical research. Specifically, the instrument will provide very high spatial resolution (< 100 mm), ultra fast frame speeds (< 1 second), and low radiation dose to the subject. This will be achieved utilizing a photon counting mode for x-ray acquisition, instead of the standard current integration mode. The system will be capable of gross energy information and energy binning, and thus will provide "Color-CT(tm)" capability, allowing tissue compositional analysis. To accomplish these advances, the system will feature advanced CdZnTe solid state detectors, coupled to high speed integrated circuits for signal processing, to achieve performance characteristics not currently possible from conventional technologies used by the major CT manufacturers. During the Phase I project, we will develop an x-ray detector module incorporating a 4 x 64 pixel CdZnTe detector, coupled to high speed custom integrated circuit readout electronics. The detector performance will be evaluated in response to a high intensity x-ray flux, on an existing CT gantry, with regard to spectral quality, energy resolution and count rate performance. The detector capabilities will be evaluated in a side-by-side comparison with a commercial integrating mode volume-CT detector, with regard to required system specifications such as contrast, dose, and acquisition speed. In Phase II, a fast dynamic multi-slice Color-CT(tm) scanner prototype will be developed, employing multiple detector modules in a novel system design incorporating a very fast x-ray source.
描述(由申请人提供):市售微型CT(计算机断层扫描)系统未能满足小动物成像的挑战性需求,超出了良好空间分辨率的单一要求。具体来说,他们没有考虑到,与人类相比,小鼠的体积小一千倍,心率也快十倍,呼吸频率和循环时间增加。因此,当前可用的系统被限制于:(1)体内体积CT,其主要用于解剖学图像与由正电子发射断层摄影(PET)或单光子发射计算机断层摄影(SPECT)提供的功能图像的配准,但是非常慢(几分钟);或(2)离体高空间分辨率CT,对于样本成像具有良好的对比度分辨率,但对于活体受试者剂量过高。因此,这些商业系统都未能解决微型CT的重要应用,例如肿瘤灌注和心脏射血分数研究。该项目的目标是开发下一代微型CT,用于药物开发和医学研究的临床前成像。该系统将被设计为在小鼠和大鼠体内提供临床质量的CT图像,其性能规格经过优化,以适应目前医学研究中最关键领域的苛刻要求。具体而言,该仪器将提供非常高的空间分辨率(< 100 mm)、超快的帧速度(< 1秒)和对受试者的低辐射剂量。这将利用光子计数模式进行X射线采集,而不是标准电流积分模式。该系统将能够提供总能量信息和能量分箱,因此将提供“Color-CT(tm)”能力,允许组织成分分析。为了实现这些进步,该系统将采用先进的CdZnTe固态探测器,与高速集成电路耦合进行信号处理,以实现主要CT制造商使用的传统技术目前无法实现的性能特性。 在第一阶段项目中,我们将开发一个X射线探测器模块,该模块包含一个4 x 64像素的CdZnTe探测器,并与高速定制集成电路读出电子设备相耦合。将在现有CT机架上评价探测器响应高强度X射线通量的性能,包括光谱质量、能量分辨率和计数率性能。将在与商业积分模式容积CT探测器的并排比较中评价探测器能力,涉及所需的系统规格,如对比度、剂量和采集速度。在第二阶段,将开发快速动态多层Color-CT(TM)扫描仪原型,在新型系统设计中采用多个探测器模块,并结合非常快的X射线源。

项目成果

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BRADLEY E PATT其他文献

BRADLEY E PATT的其他文献

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{{ truncateString('BRADLEY E PATT', 18)}}的其他基金

Next Generation microCT
下一代显微CT
  • 批准号:
    7329657
  • 财政年份:
    2005
  • 资助金额:
    $ 9.36万
  • 项目类别:
Next Generation microCT
下一代显微CT
  • 批准号:
    7500278
  • 财政年份:
    2005
  • 资助金额:
    $ 9.36万
  • 项目类别:
Animal SPECT camera for functional microimaging of brain
用于大脑功能显微成像的动物 SPECT 相机
  • 批准号:
    6931855
  • 财政年份:
    2003
  • 资助金额:
    $ 9.36万
  • 项目类别:
Animal SPECT camera for functional microimaging of brain
用于大脑功能显微成像的动物 SPECT 相机
  • 批准号:
    6883964
  • 财政年份:
    2003
  • 资助金额:
    $ 9.36万
  • 项目类别:
Animal SPECT camera for functional microimaging of brain
用于大脑功能显微成像的动物 SPECT 相机
  • 批准号:
    6735662
  • 财政年份:
    2003
  • 资助金额:
    $ 9.36万
  • 项目类别:
Animal SPECT camera for functional microimaging of brain
用于大脑功能显微成像的动物 SPECT 相机
  • 批准号:
    6644622
  • 财政年份:
    2003
  • 资助金额:
    $ 9.36万
  • 项目类别:
High-Resolution 3D Breast Tomograph for Early Cancer De*
用于早期癌症 De* 的高分辨率 3D 乳房断层扫描
  • 批准号:
    6668715
  • 财政年份:
    2002
  • 资助金额:
    $ 9.36万
  • 项目类别:
GSO PET/SPECT Imaging System for Radiopharmaceuticals
用于放射性药物的 GSO PET/SPECT 成像系统
  • 批准号:
    6444920
  • 财政年份:
    2002
  • 资助金额:
    $ 9.36万
  • 项目类别:
High-Resolution 3D Breast Tomograph for Early Cancer De*
用于早期癌症 De* 的高分辨率 3D 乳房断层扫描
  • 批准号:
    6480331
  • 财政年份:
    2002
  • 资助金额:
    $ 9.36万
  • 项目类别:
NOVEL PHOTOSENSOR FOR SCINTILLATION CAMERAS
用于闪烁相机的新型光电传感器
  • 批准号:
    6549371
  • 财政年份:
    2002
  • 资助金额:
    $ 9.36万
  • 项目类别:
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