GSO PET/SPECT Imaging System for Radiopharmaceuticals

用于放射性药物的 GSO PET/SPECT 成像系统

• 批准号: 6444920
• 负责人: BRADLEY E PATT
• 金额: $ 8.1万
• 依托单位: PHOTON IMAGING, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2003-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6444920
• 关键词: bioimaging /biomedical imaging; electromagnetic radiation; image processing; positron emission tomography; radiopharmacology; scintillation counter; single photon emission computed tomography; technology /technique development

DESCRIPTION (provided by applicant): This is a proposal to develop a high-resolution combined single photon (SPECT) and positron emission tomograph (PET). The dual PET/SPECT scanner will have excellent spatial resolution and sensitivity making quantitative analysis of in vivo functional animal imaging possible. This scanner will greatly facilitate the development and evaluation of imaging agents and pharmaceuticals that are used for a broad variety of diagnostic, therapeutic, therapy monitoring and experimental purposes. The medical fields that benefit from nuclear emission imaging include cardiology, endocrinology, hematology, oncology, osteology, neurology and genetic manipulation and modeling. The PET/SPECT offers great potential to more effectively evaluate the efficacy of agents by replacing current ex vivo, time consuming and expensive methods with more accurate tests in live rodent models. The PET/SPEC utilizes GSO scintillators that provide the necessary performance for both PET and SPECT which are traditionally separate machines. Recent efforts to combine PET and SPECT on human scanners are widespread. Likewise, there is great interest in animal PET and SPECT. This is the first commercial effort to combine PET and SPECT for animals. An extremely versatile electronics processing and data handling scheme will combine with advanced technology scintillators and photosensors to meet the challenge of combining two imaging modalities with very different performance demands. During Phase I we will assemble 1-inch prototypes of the system detectors and characterize the single photon (at 140 keV) and coincidence (511 keV) response in terms of detector efficiency. Energy resolution, timing resolution, and other important characteristics as a proof of feasibility for the full system will be developed in Phase II.

描述（由申请人提供）：这是一个开发 高分辨率SPECT和正电子发射断层扫描仪 （PET）。双PET/SPECT扫描仪将具有出色的空间分辨率， 活体功能动物成像定量分析的灵敏度 可能这种扫描仪将大大方便开发和评估 成像剂和药物，用于各种各样的 诊断、治疗、治疗监测和实验目的。的 受益于核发射成像的医学领域包括心脏病学， 内分泌学、血液学、肿瘤学、骨骼学、神经学和遗传学 操纵和建模。PET/SPECT具有巨大的潜力， 通过替代当前的离体、时间 在活体啮齿动物模型中进行更精确的测试。 PET/SPEC利用GSO蒸发器提供必要的性能 对于PET和SPECT这两种传统上是独立的机器。最近 在人体扫描仪上结合联合收割机PET和SPECT的努力是广泛的。同样地， 对动物PET和SPECT有很大的兴趣。这是第一个广告 努力将联合收割机PET和SPECT用于动物。一种极其通用的电子产品 处理和数据处理方案将联合收割机与先进技术相结合 用于应对将两种成像技术相结合的挑战的光电转换器和光电传感器 具有非常不同的性能要求的模式。 在第一阶段，我们将组装1英寸的系统探测器原型， 表征单光子（140 keV）和符合（511 keV）响应 在探测器效率方面。能量分辨率、时间分辨率和 作为整个系统可行性证明的其他重要特性 将在第二阶段开发。