GSO PET/SPECT Imaging System for Radiopharmaceuticals

描述(由申请人提供)：这是一项开发 高分辨率单光子(SPECT)正电子发射断层扫描仪 (宠物)。双PET/SPECT扫描仪将具有出色的空间分辨率和 活体动物功能成像的灵敏度定量分析 有可能。该扫描仪将极大地方便开发和评估 用于多种疾病的显像剂和药物 诊断、治疗、治疗监测和实验目的。这个 受益于核辐射成像的医学领域包括心脏病学， 内分泌学、血液学、肿瘤学、骨科、神经学和遗传学 操纵和建模。PET/SPECT提供了巨大的潜力 通过取代目前的体外实验时间有效地评估药物的疗效 耗费和昂贵的方法，在活体啮齿动物模型中进行更准确的测试。 PET/SPEC使用GSO闪烁体，提供必要的性能 对于PET和SPECT这两种传统上独立的机器。近期 在人体扫描仪上将PET和SPECT结合起来的努力很普遍。同样， 动物正电子发射计算机断层扫描和正电子发射计算机断层扫描引起了人们的极大兴趣。这是第一个广告 努力将PET和SPECT结合起来，用于动物。用途极其广泛的电子产品 处理和数据处理方案将与先进技术相结合 闪烁体和光传感器，以迎接将两种成像结合在一起的挑战 性能要求非常不同的模式。 在第一阶段，我们将组装1英寸的系统探测器原型，并 表征单光子(140keV)和符合(511keV)响应 在探测器效率方面。能量分辨率、时间分辨率和 作为整个系统可行性证明的其他重要特征 将在第二阶段开发。

DESCRIPTION (provided by applicant): This is a proposal to develop a high-resolution combined single photon (SPECT) and positron emission tomograph (PET). The dual PET/SPECT scanner will have excellent spatial resolution and sensitivity making quantitative analysis of in vivo functional animal imaging possible. This scanner will greatly facilitate the development and evaluation of imaging agents and pharmaceuticals that are used for a broad variety of diagnostic, therapeutic, therapy monitoring and experimental purposes. The medical fields that benefit from nuclear emission imaging include cardiology, endocrinology, hematology, oncology, osteology, neurology and genetic manipulation and modeling. The PET/SPECT offers great potential to more effectively evaluate the efficacy of agents by replacing current ex vivo, time consuming and expensive methods with more accurate tests in live rodent models. The PET/SPEC utilizes GSO scintillators that provide the necessary performance for both PET and SPECT which are traditionally separate machines. Recent efforts to combine PET and SPECT on human scanners are widespread. Likewise, there is great interest in animal PET and SPECT. This is the first commercial effort to combine PET and SPECT for animals. An extremely versatile electronics processing and data handling scheme will combine with advanced technology scintillators and photosensors to meet the challenge of combining two imaging modalities with very different performance demands. During Phase I we will assemble 1-inch prototypes of the system detectors and characterize the single photon (at 140 keV) and coincidence (511 keV) response in terms of detector efficiency. Energy resolution, timing resolution, and other important characteristics as a proof of feasibility for the full system will be developed in Phase II.