Animal SPECT camera for functional microimaging of brain

用于大脑功能显微成像的动物 SPECT 相机

• 批准号: 6883964
• 负责人: BRADLEY E PATT
• 金额: $ 45.01万
• 依托单位: GAMMA MEDICA-IDEAS, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2006-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6883964
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; computer simulation; image enhancement; image processing; miniature biomedical equipment; scintillation cameras; semiconduction; single photon emission computed tomography

DESCRIPTION (provided by applicant): This is a proposal to develop a very high-resolution gamma ray Single Photon Emission Computed Tomography (SPECT) camera capable of imaging a wide variety of laboratory animals, from the brain of non-human primates to the whole body of a rat or mouse. The system also includes high-resolution x-ray Computed Tomography (CT) imaging capability of the same subject volume as the SPECT scanner. The imaging characteristics will surpass those of current clinical systems by employing an innovative gamma-ray detector system and collimator geometry that is designed specifically for this application. The camera developed here will meet a new and increasing demand for higher resolution, quantitative, and functional micro imaging in the laboratory setting. Applications include imaging of the central nervous system of non-human primates for the purposes of furthering our knowledge about the functional processes at the micro-level, developing diagnostic and therapeutic pharmaceuticals, and imaging of other animals for the development of cancer seeking radiopharmaceuticals for both diagnostic and therapeutic purposes. Semiconductor radiation detectors have evolved to the extent that we are now able to replace existing technology with solid-state technology that provides both improved performance and more compact designs. The system will consist of over 9000 16 mm solid-state detector pixels with mean energy resolution of 58% IFWHM at 140 keV This represents improvements in intrinsic spatial resolution and energy resolution of a factor of two compared with conventional gamma cameras. The prototype scanner will be capable of non-invasive, internal, in vivo, quantitative functional and fully 3-dimensional imaging of animals from mice to non-human primate brains.

描述（由申请人提供）： 这是一个建议，开发一个非常高分辨率的伽马射线单光子发射计算机断层扫描（SPECT）相机能够成像各种各样的实验室动物，从非人类灵长类动物的大脑到大鼠或小鼠的全身。该系统还包括与SPECT扫描仪相同的受试者体积的高分辨率X射线计算机断层扫描（CT）成像能力。通过采用创新的伽马射线探测器系统和专门为此应用设计的准直器几何结构，成像特性将超过当前临床系统的成像特性。这里开发的相机将满足实验室环境中对更高分辨率，定量和功能性显微成像的新的和不断增长的需求。应用包括非人类灵长类动物的中枢神经系统成像，以进一步了解微观层面的功能过程，开发诊断和治疗药物，以及其他动物的成像，以开发癌症，寻求用于诊断和治疗目的的放射性药物。半导体辐射探测器已经发展到我们现在能够用固态技术取代现有技术的程度，该技术提供了改进的性能和更紧凑的设计。该系统将由超过9000个16 mm固态探测器像素组成，在140 keV时平均能量分辨率为58%IFWHM。与传统伽马相机相比，这代表了固有空间分辨率和能量分辨率的提高。原型扫描仪将能够对从小鼠到非人类灵长类动物的大脑进行非侵入性、内部、体内、定量功能和全三维成像。