The Ohio State University Vision Sciences Research Core Program (OSU-VSRCP)

俄亥俄州立大学视觉科学研究核心计划 (OSU-VSRCP)

• 批准号: 10707323
• 负责人: Sayoko E Moroi
• 金额: $ 57.12万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10707323
• 关键词: Agreement; Angiography; Animal Model; Architecture; Artificial Intelligence; Arts; Bioinformatics; Biometry; Blindness; Cell model; Clinical Research; Collaborations; Communities; Computers; Core Facility; Data; Data Analyses; Data Commons; Data Science; Data Science Core; Data Set; Data Storage and Retrieval; Development; Electrophysiology (science); Engineering; Ensure; Environment; Equipment; Evaluation; Eye diseases; Faculty; Faculty Recruitment; Funding; Fundus photography; Genes; Genetic; Genomics; Goals; Health Services; Health Services Research; High Performance Computing; Human; Image Analysis; Individual; Institution; Interdisciplinary Study; Lasers; Leadership; Learning; Letters; Machine Learning; Medical center; Medicine; Microscope; Morphology; Neurosciences; Ohio; Ophthalmology; Optometry; Outcome; Pathway Analysis; Pediatric Hospitals; Pediatrics; Procedures; Protocols documentation; Psychology; Research; Research Design; Research Personnel; Research Project Grants; Resources; Science; Scientist; Service delivery model; Services; Strategic Planning; Surveys; System; Technical Expertise; Thinking; Training; Universities; Variant; Veterinary Medicine; Vision; Vision research; advanced analytics; analytical tool; biomedical informatics; clinical translation; cluster computing; college; computer science; cost; data mining; design; equipment acquisition; flexibility; genetic analysis; genomic data; high standard; image guided; image processing; implementation science; manufacture; meetings; model organism; prevent; programs; recruit; research facility; response; sight restoration; statistics; supercomputer; synergism; tonometry; vision science

OVERALL MULTI-COMPONENT NEI P30 PROPOSAL abstract The Ohio State University Vision Sciences Research Core Program (OSU-VSRCP) has established the expanding vision research scientists across five academic units (i.e., College of Medicine (COM), College of Optometry (COO), College of Engineering (COE), College of Veterinary Medicine, College of Arts and Sciences) and newly engaged Nationwide Children’s Hospital. Program Director (PD) Dr. Moroi has commitment from Deans and Chairs to purchase equipment (i.e., confocal microscope), support data science, assign scarce space, and increase collaborations. The leadership and scientists are aligned with the NEI PAR- 20-051 ‘to enhance the capabilities of participating NEI-funded investigators and the institution for conducting vision research.’ Synergy of this community has been established with monthly ViSOR (Vision Sciences OSU Research) seminars. Synergy between Cores has been defined by the Steering Committee composed of the PD, Core Directors and Co-directors, who represent Dept. Ophthalmology and Visual Sciences (DOVS), Dept. Neuroscience, Dept. Biomedical Informatics, Dept. Computer Science (COE), and COO. Synergy between Cores will coincide with monthly ViSOR meetings. In addition, an Advisory Group will provide guidance twice a year to the Steering Committee. Based on a survey of 61 scientists, three scientific cores are proposed, which are re-organized in response to the prior review led by a Director and Co-director, with at least one of the leaders holding an NEI R01. Core A: Structural and Functional Assessments (SFA) Core A provides technical expertise and well-maintained state-of-the-art equipment for functional and morphological assessment of cells and animal models used in vision research. Dr. Moroi arranged the added value of machine shop services with an agreement with Executive Director Mr. Nate Ames (see letter) of The OSU Center for Design and Manufacturing Excellence (CDME) to enhance funded research projects. Core B: Biostatistics, Bioinformatics and Genetic Analysis (BBGA) Core B was re-organized to consolidate services for traditional statistics and statistical genetics. Users can obtain assistance in research design and traditional statistics, as well as bioinformatics, pathway analysis, and large-scale genomic data mining that require advanced computational analytics. Core C: Image Analysis and Data Science (IADS) Core C was re- organized in response to the growing need for image processing, analysis and data science expertise including machine learning and artificial intelligence (AI) and development of a Data Commons Architecture for the OSU vision community. The expected outcome is increased collaboration for successful new proposals with the shared overarching goal to prevent blindness, restore vision and develop cures for eye diseases.

总体多组件NEI P30提案摘要 俄亥俄州州立大学视觉科学研究核心计划（OSU-VSRCP）已经建立了 将视觉研究科学家扩展到五个学术单位（即，医学院（COM）， 验光（COO），工程学院（COE），兽医学院，艺术学院和 新成立的全国儿童医院。项目总监（PD）Moroi博士 院长和主席购买设备的承诺（即，共聚焦显微镜），支持数据科学， 分配稀缺的空间，增加合作。领导层和科学家与NEI PAR保持一致- 20-051“，以提高参与NEI资助的研究人员和机构的能力， 视觉研究”。这个社区的协同作用已经建立了每月的ViSOR（视觉科学OSU 研究）研讨会。核心之间的协同作用已由指导委员会确定， PD、核心董事和联席董事，代表部门。眼科和视觉科学（DOVS），部门。 神经科学系生物医学信息学系计算机科学（COE）和COO。之间的协同作用 核心将与每月的ViSOR会议同时举行。此外，一个咨询小组将提供两次指导， 年，指导委员会。根据对61位科学家的调查，提出了三个科学核心， 根据董事和联席董事领导的事先审查进行重组，其中至少有一个 持有NEI R 01的领导人。核心A：结构和功能评估（SFA）核心A提供 技术专长和维护良好的最先进设备， 评估用于视觉研究的细胞和动物模型。Moroi博士安排了 与OSU执行董事Nate艾姆斯先生（见信函）达成协议的机械车间服务 卓越设计和制造中心（CDME），以加强资助的研究项目。核心B： 生物统计学、生物信息学和遗传分析（BBGA）核心B进行了重组， 传统统计和统计遗传学服务。用户可以获得研究设计方面的帮助， 传统的统计学，以及生物信息学，途径分析和大规模基因组数据挖掘， 需要先进的计算分析Core C：图像分析和数据科学（IADS）Core C被重新设计， 为满足对图像处理、分析和数据科学专业知识日益增长的需求， 机器学习和人工智能（AI）以及为OSU开发数据共享架构 愿景社区预期的结果是，为成功的新提案加强与 共同的首要目标是预防失明，恢复视力和开发治疗眼疾的方法。