SEARCH for Diabetes in Youth Coordinating Center

在青年协调中心寻找糖尿病患者

• 批准号: 7087467
• 负责人: Ronny A Bell
• 金额: $ 119.99万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2010-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7087467
• 关键词: SEARCH; Diabetes; Youth; Coordinating; Center

DESCRIPTION (provided by applicant): This proposal describes the development, implementation and maintenance of a data coordinating center (CoC) for the second phase of the SEARCH for Diabetes in Youth Study. The SEARCH study CoC is being proposed by a team of investigators from the Wake Forest University School of Medicine (WFUSM) in response to an RFA from the Centers for Disease Control and Prevention entitled, "Incidence, Natural History, and Quality of Life of Diabetes in Youth" (RFA-DP-05-069). WFUSM is well positioned to serve in this capacity, having served as the CoC for the first phase of the SEARCH study since 2001. This study was a six-center study examining the prevalence, incidence, and clinical presentation of diabetes among youth 0-19 years by diabetes type, ethnicity, gender and age, since 2001. Data from over 10,000 youth, representing prevalent cases in 2001 and incident cases in 2005-2005 at the six SEARCH centers (South Carolina, Cincinnati, Seattle, Southern California, Colorado, Hawaii), is currently being stored and analyzed by the WFUSM SEARCH CoC. The WFUSM will provide statistical and operational support to address the following study aims proposed by the original SEARCH clinic sites for the second phase of SEARCH: (1) to prospectively ascertain newly diagnosed (2006-2008) incident diabetes cases in children/youth <20 years of age and collect data that permits estimation of temporal trends in diabetes incidence by age-group, gender, race/ethnicity and diabetes type for the period 2002-2008; (2) to conduct longitudinal follow-up of incident cases already recruited to SEARCH in 2003-2005 in order to document the evolution of newly diagnosed diabetes according to clinical and biochemical factors and characterize the evolution of key risk factors for diabetes complications, according to diabetes type and race/ethnicity; (3) to assess the impact of quality of diabetes care in youth on short-and long-term outcomes including quality of life by completing analytic work initiated in SEARCH as described in the Quality of Care Roadmap and expanding the scope of quality of care assessment initiated in SEARCH in order to explore the interrelationships of patient characteristics, important domains of health care with outcomes, including glycemic control, satisfaction with care, receipt of recommended services, complications, and quality of life; and (4) to develop and validate simple and low-cost case definitions and classifications of diabetes types in youth that can be used for public health surveillance. Additionally, the WFUSM CoC will develop a plan to secure a central laboratory for the SEARCH study for storage and analysis of blood and urine sample and storage of DNA for ancillary studies. This phase of the SEARCH study will build on the knowledge gained in the first phase of the study, and will provide valuable clinical and public health information to address the growing problem of childhood diabetes.

描述（由申请人提供）：该提案描述了青年糖尿病研究第二阶段数据协调中心（CoC）的开发、实施和维护。 SEARCH 研究 CoC 是由维克森林大学医学院 (WFUSM) 的一组研究人员针对疾病控制与预防中心题为“青少年糖尿病的发病率、自然史和生活质量”(RFA-DP-05-069) 的 RFA 提出的。 WFUSM 自 2001 年以来一直担任 SEARCH 研究第一阶段的 CoC。这项研究是一项六中心研究，自 2001 年以来按糖尿病类型、种族、性别和年龄检查 0-19 岁青少年糖尿病的患病率、发病率和临床表现。数据来自 10,000 多名青少年，代表 2001 年的流行病例和 2005-2005 年的事件病例，网址为：六个搜索中心 （南卡罗来纳州、辛辛那提、西雅图、南加州、科罗拉多州、夏威夷）目前由 WFUSM SEARCH CoC 进行存储和分析。 WFUSM 将提供统计和操作支持，以实现最初的 SEARCH 诊所站点为 SEARCH 第二阶段提出的以下研究目标：(1) 前瞻性地确定 20 岁以下儿童/青少年中新诊断的（2006-2008 年）糖尿病病例，并收集数据，以便估计该时期按年龄组、性别、种族/民族和糖尿病类型划分的糖尿病发病率的时间趋势。 2002-2008； (2) 对 2003-2005 年 SEARCH 中已招募的事件病例进行纵向随访，以便根据临床和生化因素记录新诊断糖尿病的演变，并根据糖尿病类型和种族/民族描述糖尿病并发症关键危险因素的演变； (3) 通过完成护理质量路线图中所述的 SEARCH 中启动的分析工作，并扩大 SEARCH 中启动的护理质量评估范围，评估青少年糖尿病护理质量对短期和长期结果（包括生活质量）的影响，以探索患者特征、医疗保健重要领域与结果之间的相互关系，包括血糖控制、护理满意度、接受推荐服务、并发症和治疗质量 生活; (4) 制定并验证可用于公共卫生监测的简单、低成本的病例定义和青少年糖尿病类型分类。 此外，WFUSM CoC 将制定一项计划，为 SEARCH 研究建立一个中心实验室，用于存储和分析血液和尿液样本以及存储用于辅助研究的 DNA。 这一阶段的 SEARCH 研究将建立在第一阶段研究所获得的知识的基础上，并将提供有价值的临床和公共卫生信息，以解决日益严重的儿童糖尿病问题。