SEARCH for Diabetes in Youth Coordinating Center

在青年协调中心寻找糖尿病患者

• 批准号: 7260537
• 负责人: Ronny A Bell
• 金额: $ 114.48万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2010-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7260537
• 关键词: SEARCH; Diabetes; Youth; Coordinating; Center

This proposal describes the development, implementation and maintenance of a data coordinating center (CoC) for the second phase of the SEARCH for Diabetes in Youth Study. The SEARCH study CoC is being proposed by a team of investigators from the Wake Forest University School of Medicine (WFUSM) in response to an RFA from the Centers for Disease Control and Prevention entitled, "Incidence, Natural History, and Quality of Life of Diabetes in Youth" (RFA-DP-05-069). WFUSM is well positioned to serve in this capacity, having served as the CoC for the first phase of the SEARCH study since 2001. This study was a six-center study examining the prevalence, incidence, and clinical presentation of diabetes among youth 0 - 19years by diabetes type, ethnicity, gender and age, since 2001. Data from over 10,000 youth, representing prevalent cases in 2001 and incident cases in 2002 - 2005 atthe six SEARCH centers (South Carolina, Cincinnati, Seattle, Southern California, Colorado, Hawaii), is currently being stored and analyzed by the WFUSM SEARCH CoC. The WFUSM will provide statistical and operational support to address the following study aims proposed by the original SEARCH clinic sites for the second phase of SEARCH: (1) to prospectively ascertain newly diagnosed (2006-2008) incident diabetes cases in children/youth <20 years of age and collect data that permits estimation of temporal trends in diabetes incidence by age-group, gender, race/ethnicity anddiabetes type for the period 2002 - 2008; (2) to conduct longitudinal follow-up of incident cases already recruited to SEARCH in 2003 - 2005 in order to document the evolution of newly diagnosed diabetes according to clinical and biochemical factors and characterize the evolution of key risk factors for diabetes complications, according to diabetes type and race/ethnicity; (3) to assess the impact of quality of diabetes care in youth on short- and long-term outcomes including quality of life by completing analytic work initiated in SEARCH as described in the Quality of Care Roadmap and expanding the scope of quality of care assessment initiated in SEARCH in order to explore the interrelationships of patient characteristics, important domains of health care with outcomes, including glycemic control, satisfaction with care, receipt of recommended services, complications, and quality of life; and (4) to develop and validate simple and low- cost case definitions and classifications of diabetes types in youth that can be used for public health surveillance. Additionally, the WFUSM CoC will develop a plan to secure a central laboratory for the SEARCH study for storage and analysis of blood and urine sample and storage of DNA for ancillary studies. This phase of the SEARCH study will build on the knowledge gained in the first phase of the study, and will provide valuable clinical and public health information to address the growing problem of childhood diabetes.

本提案描述了数据协调中心的开发、实施和维护 (CoC)青年糖尿病研究的第二阶段。该研究CoC正在 由维克森林大学医学院（WFUSM）的一组研究人员提出， 对疾病控制和预防中心题为“自然发病率， 青年糖尿病病史和生活质量”（RFA-DP-05-069）。WFUSM是一个很好的定位， 自2001年以来，一直担任第一阶段研究的CoC。本研究 一项六中心研究调查了0岁以下青少年糖尿病的患病率、发病率和临床表现， - 自2001年以来，按糖尿病类型、种族、性别和年龄划分的19岁。来自10 000多名青年的数据， 代表2001年的流行病例和2002 - 2005年六个艾滋病中心（南 卡罗莱纳州、辛辛那提、西雅图、南加州、科罗拉多州、夏威夷），目前正在存储和分析 由WFUSM的CoC。世界大学生运动联合会将提供统计和业务支持， 第二阶段研究计划的原研究地点建议的研究目的如下：（1） 前瞻性地确定2006-2008年儿童/青少年中新诊断的糖尿病病例， 年龄和收集数据，允许按年龄组，性别， 2002 - 2008年期间的种族/民族和糖尿病类型;（2）对事件进行纵向随访 2003 - 2005年已招募的病例，以记录新诊断的 糖尿病根据临床和生化因素和特征的演变的关键危险因素， 糖尿病并发症，根据糖尿病类型和种族/民族;（3）评估质量的影响， 通过完成分析工作，对青年糖尿病护理的短期和长期结果，包括生活质量 如护理质量路线图中所述， 护理评估始于1998年为了探索患者特征的相互关系， 健康护理的重要领域与结果，包括血糖控制，对护理的满意度， 推荐的服务，并发症和生活质量;（4）开发和验证简单和低- 可用于公共卫生的青年糖尿病类型的成本案例定义和分类 监视此外，WFUSM CoC将制定一项计划，为 血液和尿液样本的储存和分析以及辅助研究DNA的储存。 这一阶段的可持续发展研究将以第一阶段研究所获得的知识为基础， 提供有价值的临床和公共卫生信息，以解决日益严重的儿童糖尿病问题。