Arsenic Exposure and Bladder Cancer in Michigan

密歇根州的砷暴露与膀胱癌

• 批准号: 7116195
• 负责人: JEROME NRIAGU
• 金额: $ 6.14万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7116195
• 关键词: arsenic; bladder neoplasm; cancer registry /resource; chemical carcinogen; clinical chemistry; clinical research; environment related neoplasm /cancer; environmental exposure; environmental toxicology; geographic site; human mortality; human population distribution; human subject; information systems; interview; mass spectrometry; model design /development; neoplasm /cancer epidemiology; outcomes research; skin derivative; water drinking behavior; water pollution; water sampling /testing

DESCRIPTION (provided by applicant): The objective of this proposal is to explore the factors that have contributed to the observed geographic co-clustering in bladder cancer mortality and arsenic concentrations in drinking water in Michigan. The focus will be on the spatial and spatio-temporal patterns of arsenic exposure and how these may relate to the incidence of bladder cancer in those areas of Michigan with elevated levels of arsenic in their drinking water. Reported arsenic concentrations in well waters in the study area range from 1 to 1310 mg/I, with most common levels being 5-50 mg/L. The project being proposed will consist of three components: (1) Construction of exposure scenarios with time dimension that will involve development of the novel space-time information system (STIS) model to be validated using a combination of space-and-time-dependent concentrations of arsenic measured in the study, supplementary historical information on arsenic levels in water supplies, hydrogeochemistry of the area, and self-reported residence information and water drinking habits; (2) Biomonitoring of arsenic exposure to be based on analysis of toenails (known to indicate average exposure over a relatively long time) for arsenic and a number of confounding trace elements such as selenium, zinc, copper and antimony; (3) A population-based, case-control bladder cancer study which will be used as an outcome measure for exposure to arsenic in drinking water. Bladder cancer cases (700) and controls (700, matched to cases by sex, race, and +/- 5-year age groups) will be recruited from long-term residents of the 11 counties (Genesee, Huron, lngham, Jackson, Lapeer, Livingston, Oakland, Sanilac, Shiawassee, Tuscola and Washtenaw) with elevated levels of arsenic in their groundwater. Structured personal interviews will be administered to obtain information on lifetime residential history, current and past water consumption patterns, life-style risk factors (including cigarette smoking and alcohol use), medical history, occupational history, family history of cancer, and dietary habits. The study is designed to shed some light on the dose-response relations for exposure of the U.S. population to arsenic concentrations in the 5-100 mg/L range where no information currently exists. Current efforts by the U.S. Environmental Protection Agency to reduce the maximum contaminant level for arsenic in our drinking water have been bedeviled by contradictory and unvalidated predictions of the risks of chronic exposure to low levels (< 100 mg/L) of arsenic in water.

描述（由申请人提供）：该提案的目的是 探索导致观测到的地理现象的因素 膀胱癌死亡率和砷浓度的共聚类 密歇根州的饮用水。重点将放在空间和 砷暴露的时空模式及其与砷暴露的关系 密歇根州膀胱癌发病率升高的地区 他们的饮用水中含有砷。报告的井水中砷浓度 研究区域范围为 1 至 1310 mg/I，最常见的水平为 5-50 毫克/升。拟议的项目将由三个部分组成：(1) 构建具有时间维度的暴露场景，其中将涉及 新型时空信息系统（STIS）模型的开发 使用空间和时间依赖性浓度的组合进行验证 研究中测量的砷，砷的补充历史信息 供水水平、该地区的水文地球化学以及自我报告 居住信息和饮水习惯； (2)砷的生物监测 暴露基于对脚趾甲的分析（已知表明平均 暴露在相对较长的时间）砷和一些混杂因素 硒、锌、铜、锑等微量元素； （3）A 基于人群的病例对照膀胱癌研究，该研究将用作 饮用水中砷暴露的结果测量。膀胱癌病例 (700) 和对照组 (700，按性别、种族和 +/- 5 岁年龄与病例相匹配 团体）将从 11 个县（杰纳西、 休伦湖、英厄姆、杰克逊、拉皮尔、利文斯顿、奥克兰、萨尼拉克、夏瓦西、 图斯科拉和沃什特诺）地下水中砷含量升高。 将进行结构化个人访谈，以获取有关以下方面的信息 终生居住历史、当前和过去的用水模式、 生活方式风险因素（包括吸烟和饮酒）、医疗 病史、职业史、癌症家族史、饮食习惯。 该研究旨在揭示剂量反应关系 美国人暴露于浓度为 5-100 mg/L 的砷 当前不存在信息的范围。美国当前的努力 环境保护局降低最大污染物水平 我们饮用水中的砷一直受到矛盾和问题的困扰 对长期接触低水平（< 100 mg/L) 水中的砷。