Arsenic Exposure and Bladder Cancer in Michigan

密歇根州的砷暴露与膀胱癌

• 批准号: 7282150
• 负责人: JEROME NRIAGU
• 金额: $ 6.31万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7282150
• 关键词: arsenic; bladder neoplasm; cancer registry /resource; chemical carcinogen; clinical chemistry; clinical research; environment related neoplasm /cancer; environmental exposure; environmental toxicology; geographic site; human mortality; human population distribution; human subject; information systems; interview; mass spectrometry; model design /development; neoplasm /cancer epidemiology; outcomes research; skin derivative; water drinking behavior; water pollution; water sampling /testing

DESCRIPTION (provided by applicant): The objective of this proposal is to explore the factors that have contributed to the observed geographic co-clustering in bladder cancer mortality and arsenic concentrations in drinking water in Michigan. The focus will be on the spatial and spatio-temporal patterns of arsenic exposure and how these may relate to the incidence of bladder cancer in those areas of Michigan with elevated levels of arsenic in their drinking water. Reported arsenic concentrations in well waters in the study area range from 1 to 1310 mg/I, with most common levels being 5-50 mg/L. The project being proposed will consist of three components: (1) Construction of exposure scenarios with time dimension that will involve development of the novel space-time information system (STIS) model to be validated using a combination of space-and-time-dependent concentrations of arsenic measured in the study, supplementary historical information on arsenic levels in water supplies, hydrogeochemistry of the area, and self-reported residence information and water drinking habits; (2) Biomonitoring of arsenic exposure to be based on analysis of toenails (known to indicate average exposure over a relatively long time) for arsenic and a number of confounding trace elements such as selenium, zinc, copper and antimony; (3) A population-based, case-control bladder cancer study which will be used as an outcome measure for exposure to arsenic in drinking water. Bladder cancer cases (700) and controls (700, matched to cases by sex, race, and +/- 5-year age groups) will be recruited from long-term residents of the 11 counties (Genesee, Huron, lngham, Jackson, Lapeer, Livingston, Oakland, Sanilac, Shiawassee, Tuscola and Washtenaw) with elevated levels of arsenic in their groundwater. Structured personal interviews will be administered to obtain information on lifetime residential history, current and past water consumption patterns, life-style risk factors (including cigarette smoking and alcohol use), medical history, occupational history, family history of cancer, and dietary habits. The study is designed to shed some light on the dose-response relations for exposure of the U.S. population to arsenic concentrations in the 5-100 mg/L range where no information currently exists. Current efforts by the U.S. Environmental Protection Agency to reduce the maximum contaminant level for arsenic in our drinking water have been bedeviled by contradictory and unvalidated predictions of the risks of chronic exposure to low levels (< 100 mg/L) of arsenic in water.

描述（由申请人提供）：本提案的目的是

项目成果

Toenails as a biomarker of inorganic arsenic intake from drinking water and foods.

脚趾甲作为饮用水和食物中无机砷摄入量的生物标志物。

• DOI: 10.1080/15287390600755232
• 发表时间: 2007
• 期刊: Journal of toxicology and environmental health. Part A
• 作者: Slotnick,MelissaJ;Meliker,JaymieR;AvRuskin,GillianA;Ghosh,Debashis;Nriagu,JeromeO
• 通讯作者: Nriagu,JeromeO

Effects of nutritional measures on toenail arsenic concentration as a biomarker of arsenic exposure.

营养措施对脚趾甲砷浓度作为砷暴露生物标志物的影响。

• DOI: 10.1080/13547500802029050
• 发表时间: 2008
• 期刊: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
• 作者: Slotnick,MelissaJ;Meliker,JaymieR;Kannan,Srimathi;Nriagu,JeromeO
• 通讯作者: Nriagu,JeromeO

Low-level determination of six arsenic species in urine by High Performance Liquid Chromatography-Inductively Coupled Plasma-Mass Spectrometry (HPLC-ICP-MS).

采用高效液相色谱-电感耦合等离子体质谱 (HPLC-ICP-MS) 测定尿液中六种低浓度的砷。

• DOI: 10.1039/c0ay00601g
• 发表时间: 2011
• 期刊: Analytical methods : advancing methods and applications
• 作者: Rivera-Núñez,Zorimar;Linder,AaronM;Chen,Bin;Nriagu,JeromeO
• 通讯作者: Nriagu,JeromeO

Arsenic in drinking water and cerebrovascular disease, diabetes mellitus, and kidney disease in Michigan: a standardized mortality ratio analysis.

• DOI: 10.1186/1476-069x-6-4
• 发表时间: 2007-02-02
• 期刊: Environmental health : a global access science source
• 作者: Meliker JR;Wahl RL;Cameron LL;Nriagu JO
• 通讯作者: Nriagu JO

Case-control geographic clustering for residential histories accounting for risk factors and covariates.

考虑风险因素和协变量的居住史的病例对照地理聚类。

• DOI: 10.1186/1476-072x-5-32
• 发表时间: 2006
• 期刊: International journal of health geographics
• 影响因子: 4.9
• 作者: Jacquez,GeoffreyM;Meliker,JaymieR;Avruskin,GillianA;Goovaerts,Pierre;Kaufmann,Andy;Wilson,MarkL;Nriagu,Jerome
• 通讯作者: Nriagu,Jerome