Arsenic Exposure and Bladder Cancer in Michigan

密歇根州的砷暴露与膀胱癌

• 批准号: 6784038
• 负责人: JEROME NRIAGU
• 金额: $ 44.7万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6784038
• 关键词: arsenic; bladder neoplasm; cancer registry /resource; chemical carcinogen; clinical chemistry; clinical research; environment related neoplasm /cancer; environmental exposure; environmental toxicology; geographic site; human mortality; human population distribution; human subject; information systems; interview; mass spectrometry; model design /development; neoplasm /cancer epidemiology; outcomes research; skin derivative; water drinking behavior; water pollution; water sampling /testing

DESCRIPTION (provided by applicant): The objective of this proposal is to explore the factors that have contributed to the observed geographic co-clustering in bladder cancer mortality and arsenic concentrations in drinking water in Michigan. The focus will be on the spatial and spatio-temporal patterns of arsenic exposure and how these may relate to the incidence of bladder cancer in those areas of Michigan with elevated levels of arsenic in their drinking water. Reported arsenic concentrations in well waters in the study area range from 1 to 1310 mg/I, with most common levels being 5-50 mg/L. The project being proposed will consist of three components: (1) Construction of exposure scenarios with time dimension that will involve development of the novel space-time information system (STIS) model to be validated using a combination of space-and-time-dependent concentrations of arsenic measured in the study, supplementary historical information on arsenic levels in water supplies, hydrogeochemistry of the area, and self-reported residence information and water drinking habits; (2) Biomonitoring of arsenic exposure to be based on analysis of toenails (known to indicate average exposure over a relatively long time) for arsenic and a number of confounding trace elements such as selenium, zinc, copper and antimony; (3) A population-based, case-control bladder cancer study which will be used as an outcome measure for exposure to arsenic in drinking water. Bladder cancer cases (700) and controls (700, matched to cases by sex, race, and +/- 5-year age groups) will be recruited from long-term residents of the 11 counties (Genesee, Huron, lngham, Jackson, Lapeer, Livingston, Oakland, Sanilac, Shiawassee, Tuscola and Washtenaw) with elevated levels of arsenic in their groundwater. Structured personal interviews will be administered to obtain information on lifetime residential history, current and past water consumption patterns, life-style risk factors (including cigarette smoking and alcohol use), medical history, occupational history, family history of cancer, and dietary habits. The study is designed to shed some light on the dose-response relations for exposure of the U.S. population to arsenic concentrations in the 5-100 mg/L range where no information currently exists. Current efforts by the U.S. Environmental Protection Agency to reduce the maximum contaminant level for arsenic in our drinking water have been bedeviled by contradictory and unvalidated predictions of the risks of chronic exposure to low levels (< 100 mg/L) of arsenic in water.

描述(由申请人提供)：本提案的目的是 探索影响观察到的地理位置的因素 膀胱癌死亡率和砷浓度的共同聚集性 在密歇根州喝水。重点将放在空间和 砷暴露的时空模式以及这些模式可能与 密歇根州膀胱癌发病率升高的地区 他们的饮用水中含有砷。井水中报告的砷含量 在研究区域内，含量范围为1至1310毫克/升，最常见的水平为5-50 建议的项目将由三个部分组成：(1) 构建具有时间维度的暴露情景，将涉及 发展新的时空信息系统(STIS)模型将是 使用空间和时间依赖的浓度组合进行验证 研究中测得的砷，关于砷的补充历史信息 供水水平、该地区的水文地球化学和自我报告 居住地信息和饮水习惯；(2)砷的生物监测 暴露基于对脚趾甲的分析(已知为平均 暴露在相对较长的时间内)砷和一些混杂的 硒、锌、铜、锑等微量元素； 以人群为基础的膀胱癌病例对照研究将被用作 饮用水中砷暴露的结果衡量标准。膀胱癌病例 (700人)和对照组(700人，按性别、种族和+/-5岁年龄匹配 小组)将从11个县的长期居民(Genesee， 休伦，英汉，杰克逊，拉皮尔，利文斯顿，奥克兰，萨尼拉克，夏瓦西， 托斯可拉和华盛顿)的地下水中砷含量较高。 将进行有组织的个人面谈，以获取有关 终身居住历史，现在和过去的用水模式， 生活方式危险因素(包括吸烟和饮酒)、医疗 病史、职业史、癌症家族史和饮食习惯。 这项研究旨在阐明以下物质的剂量-反应关系 美国人群暴露于5-100 mg/L砷浓度的研究 当前不存在任何信息的范围。美国目前的努力。 环境保护局将降低 我们饮用水中的砷一直受到矛盾和 长期暴露于低水平(&lt；100)风险的未经验证的预测 Mg/L)水中砷。