How are axons guided to their targets in the developing nervous system?

轴突如何引导神经系统发育中的目标？

• 批准号: nhmrc : 1107986
• 负责人: Prof Geoffrey Goodhill
• 金额: $ 22.55万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/axons-guided-targets-nervous-system/663013
• 关键词: How; axons; guided; their; targets

Many neurodevelopmental disorders are probably the result of wiring defects. In this project we will use new technologies to study how growing nerve fibres are steered to their targets during development, and use this data to create new mathematical models which can predict which way nerve fibres should grow in different situations. This will advance our understanding of the mechanisms underlying both normal and abnormal brain development.

许多神经发育障碍可能是神经连接缺陷的结果。在这个项目中，我们将使用新技术来研究生长的神经纤维在发育过程中是如何引导到它们的目标的，并使用这些数据来创建新的数学模型，该模型可以预测神经纤维在不同情况下的生长方式。这将促进我们对大脑正常和异常发育的机制的理解。