The dynamics of gradient sensing by growth cones: timelapse imaging and mathematical modelling

生长锥梯度传感的动力学：延时成像和数学建模

• 批准号: nhmrc : 456003
• 负责人: Prof Geoffrey Goodhill
• 金额: $ 32.89万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dynamics-gradient-sensing-mathematical-modelling/95045
• 关键词: dynamics; gradient; sensing; growth; cones

Problems in the wiring up of the brain underlie several nervous system disorders. The goal of this project is to understand better how this wiring normally forms. This will ultimately lead to a better understanding of what can go wrong with brain wiring, and how to fix such problems. It will also lead to a better understanding of how to make axons regenerate after injury. Our approach is to use a combination of timelapse imaging of neurons in culture, and mathematical modelling, to understand how the tips of the wires growing between neurons sense their environment. By comparing our experimental measurements with our theoretical results we will arrive at a detailed and accurate model of this sensing process. This will allow us to make predictions about how these developmental events normally occur in vivo, and what can go wrong.

大脑连接的问题是几种神经系统紊乱的原因。这个项目的目标是更好地了解这种布线通常是如何形成的。这最终将使人们更好地理解大脑连接可能会出现什么问题，以及如何解决这些问题。这也将使人们更好地理解如何使轴突在受伤后再生。我们的方法是结合培养中神经元的时间流逝成像和数学模型，来了解神经元之间生长的电线尖端如何感知环境。通过将实验测量结果与理论结果进行比较，我们将得到这一传感过程的详细而准确的模型。这将使我们能够预测这些发育事件在体内通常是如何发生的，以及可能会出现什么问题。