TESTOSTERONE FOR PREVENTION OF FRACTURE IN MEN
TESTOSTERONE FOR PREVENTION OF FRACTURE IN MEN
批准号:
6920765
负责人:
ANNE M KENNY
金额:
$29.0万
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-09-30 至 2007-06-30
关键词:
agingblood testsbody compositionbone densitybone fracturecardiovascular functionclinical trialscognitiondisease /disorder prevention /controlgeriatricshormone regulation /control mechanismhormone therapyhuman old age (65+)human subjecthuman therapy evaluationmaleosteoporosispatient oriented researchprostatequality of lifequestionnairesradiographystatistics /biometrytestosteroneurinalysis
中文摘要
描述:(逐字引用自申请)对骨质疏松症的关注在很大程度上 强调妇女的健康,很少关注诊断
和预防男性骨质疏松性骨折。然而,这种疾病也是一种
男人的重要问题睾酮水平随着年龄的增长而下降,
严重的睾酮缺乏与低骨量和骨折有关。
一些流行病学研究表明,低睾酮与
老年男性骨量低,但这一发现并不一致。有臀部的男人
骨折被发现是睾酮缺乏更经常比对照组
科目在70岁以上睾丸激素水平低于年轻正常水平的男性中,
范围内,我们发现生物可利用睾酮的差异占20
股骨下一个骨矿物质密度(FN BMD)值的方差百分比。
基于这些数据,补充睾酮可能对骨骼很重要。
老年人的健康我们将检验睾丸激素
补充可以降低随后的脊椎和非脊椎
近期髋骨骨折的老年男性。我们还将评估
睾酮对这一群体的一般健康和福祉的影响。
拟议研究的具体目标是确定
补充睾酮对椎体和非椎体骨折发生率的影响
年龄在60岁及以上的男性,最近发生过髋部骨折。两
数百名60岁及以上的男性髋部骨折
在轻度至中度创伤(如从站立高度跌落)后,
前2-6个月)将随机分配接受长效
睾酮或安慰剂注射在一项双盲研究。我们会查明
通过结构性问卷调查和随访确定的新发非椎骨骨折发生率
每6个月进行一次影像学确认,持续36个月,以及椎体
基线脊柱侧位片和每年随访侧位片的骨折率
脊椎片此外,股骨近端的骨矿物质密度(BMD),
腰椎、桡骨远端和全身双能X线吸收测定法(DXA)
将在基线时和每年进行一次,持续3年,以评估BMD的变化。
此外,我们将确定睾丸激素对一般健康的影响,
包括身体和认知功能,心血管风险,身体
组成和前列腺参数。各种身体和认知测量
将通过血脂谱评估心血管风险,
来自全身DXA和前列腺参数的身体组成将包括
前列腺特异性抗原水平,美国泌尿外科协会前列腺
症状评分和前列腺直肠指诊。
英文摘要
DESCRIPTION: (verbatim from application) Attention to osteoporosis has largely emphasized women's health, and little attention has focused on the diagnosis
and prevention of osteoporotic fractures in men. And yet the disease is also an
important problem in men. Tesosterone levels decline with advancing age, and
severe testosterone deficiency is associated with low bone mass and fracture.
Several epidemiologic studies suggest that low testosterone is associated with
low bone mass in older men, but this finding is not consistent. Men with hip
fracture are found to be testosterone deficient more often than control
subjects. Among men over age 70 with testosterone levels below young normal
range, we found differences in bioavailable testosterone accounted for 20
percent of the variance in femoral next bone mineral density (FN BMD) values.
Based on these data, testosterone supplementation may be important for bone
health in older men. We will test the hypothesis that testosterone
supplementation can decrease the risk of subsequent vertebral and non-vertebral
fractures in older men with recent hip fracture. We will also evaluate the
effects of testosterone on general health and well-being in this group.
The specific aims of the proposed study will be to determine the effect of
testosterone supplementation on vertebral and non-vertebral fractures incidence
in men, age 60 years and older, who have sustained a recent hip fracture. Two
hundred men, age 60 years and older, who have sustained a hip fracture
following mild to moderate trauma (such as a fall from a standing height in the
previous 2-6 months) will be randomly assigned to receive either long-acting
testosterone or placebo injections in a double-blind study. We will ascertain
new, non vertebral fracture incidence by structured questionnaire and follow-up
radiographic confirmation every 6 months for 36 months, as well as vertebral
fracture rates with baseline lateral spine films and yearly follow-up lateral
spine films. In addition, bone mineral density (BMD) of the proximal femur,
lumbar spine, distal radius and total body by dual x-ray absorptiometry (DXA)
will be performed at baseline and yearly for 3 years to assess changes in BMD.
In addition, we will determine the effect of testosterone on general health,
including physical and cognitive function, cardiovascular risk, body
composition and prostate parameters. Various physical and cognitive measures
will be assessed, cardiovascular risk will be assessed by lipid profile and
body composition from the whole body DXA and prostate parameters will include
prostate specific antigen levels, American Urologic Association Prostate
Symptom Score and digital rectal examination of the prostate.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Clinical Research Curriculum Award
-
批准号:8308586
-
项目类别:
-
资助金额:$24.05万
-
财政年份:2010
-
负责人:ANNE M KENNY
-
依托单位:
Clinical Research Curriculum Award
-
批准号:7884770
-
项目类别:
-
资助金额:$27.82万
-
财政年份:2010
-
负责人:ANNE M KENNY
-
依托单位:
Clinical Research Curriculum Award
-
批准号:8143472
-
项目类别:
-
资助金额:$24.28万
-
财政年份:2010
-
负责人:ANNE M KENNY
-
依托单位:
ASSESSING OSTEOPOROSIS RISK
-
批准号:7607632
-
项目类别:
-
资助金额:$0.02万
-
财政年份:2007
-
负责人:ANNE M KENNY
-
依托单位:
OMEGA-3
-
批准号:7607652
-
项目类别:
-
资助金额:$2.18万
-
财政年份:2007
-
负责人:ANNE M KENNY
-
依托单位:
TESTOSTERONE EFFECTS ON BONE AND FRAILTY IN MEN WITH OSTEOPOROSIS
-
批准号:7607584
-
项目类别:
-
资助金额:$0.64万
-
财政年份:2007
-
负责人:ANNE M KENNY
-
依托单位:
EFFECTS OF DHEA AND EXERCISE ON BONE, MUSCLE AND BALANCE
-
批准号:7607621
-
项目类别:
-
资助金额:$0.38万
-
财政年份:2007
-
负责人:ANNE M KENNY
-
依托单位:
TESTOSTERONE EFFECTS ON BONE AND FRAILTY IN MEN WITH OSTEOPOROSIS
-
批准号:7377310
-
项目类别:
-
资助金额:$4.68万
-
财政年份:2006
-
负责人:ANNE M KENNY
-
依托单位:
MUSCLE BIOPSY FRAIL VS NON-FRAIL
-
批准号:7377338
-
项目类别:
-
资助金额:$0.26万
-
财政年份:2006
-
负责人:ANNE M KENNY
-
依托单位:
EFFECTS OF DHEA AND EXERCISE ON BONE, MUSCLE AND BALANCE
-
批准号:7377357
-
项目类别:
-
资助金额:$7.52万
-
财政年份:2006
-
负责人:ANNE M KENNY
-
依托单位:
ASSESSING OSTEOPOROSIS RISK
-
批准号:7377374
-
项目类别:
-
资助金额:$0.03万
-
财政年份:2006
-
负责人:ANNE M KENNY
-
依托单位:
EFFECTS OF DHEA AND EXERCISE ON BONE, MUSCLE AND BALANCE
-
批准号:7203958
-
项目类别:
-
资助金额:$6.98万
-
财政年份:2005
-
负责人:ANNE M KENNY
-
依托单位:
MIF GENOTYPING
-
批准号:7203938
-
项目类别:
-
资助金额:$0.12万
-
财政年份:2005
-
负责人:ANNE M KENNY
-
依托单位:
TESTOSTERONE EFFECTS ON BONE AND FRAILTY IN MEN WITH OSTEOPOROSIS
-
批准号:7203903
-
项目类别:
-
资助金额:$29.29万
-
财政年份:2005
-
负责人:ANNE M KENNY
-
依托单位:
Testosterone Effects on Bone /Frailty in Men w/Osteoporo
-
批准号:6975252
-
项目类别:
-
资助金额:$14.14万
-
财政年份:2004
-
负责人:ANNE M KENNY
-
依托单位:
Mif Genotyping
-
批准号:6975311
-
项目类别:
-
资助金额:$2.2万
-
财政年份:2004
-
负责人:ANNE M KENNY
-
依托单位:
Muscle Biopsy Frail vs Nonfrail
-
批准号:6975305
-
项目类别:
-
资助金额:$0.78万
-
财政年份:2004
-
负责人:ANNE M KENNY
-
依托单位:
TESTOSTERONE FOR PREVENTION OF FRACTURE IN MEN
-
批准号:7079890
-
项目类别:
-
资助金额:$7.47万
-
财政年份:2001
-
负责人:ANNE M KENNY
-
依托单位:
TESTOSTERONE FOR PREVENTION OF FRACTURE IN MEN
-
批准号:6649679
-
项目类别:
-
资助金额:$36.25万
-
财政年份:2001
-
负责人:ANNE M KENNY
-
依托单位:
TESTOSTERONE FOR PREVENTION OF FRACTURE IN MEN
-
批准号:6756460
-
项目类别:
-
资助金额:$36.25万
-
财政年份:2001
-
负责人:ANNE M KENNY
-
依托单位:
海外基金