Evolution of Duplicate Genes at the Genomic Level

描述(由申请者提供)：我们的目标是了解过程和 真核生物基因组中重复基因进化的机制。几个 真核基因组已经完成，不久还会有几个基因组完成 完成。海量的基因组序列数据对 研究重复基因进化的各个方面。这是第一次 可以在基因组水平上研究重复基因进化的时间。至 抓住这一前所未有的机遇，我们建议开展以下工作 研究： 1.开发检测基因组中重复基因的方法，并 将蛋白质分类为家族。 2.发展检测基因组中的区块复制的方法。一台计算机 将为(1)和(2)中的方法开发软件包。 3.评估不同真核生物基因组中基因复制的程度。为 每个完整的基因组我们都会问：有多少重复基因(基因族)存在 基因组？数据块复制多久发生一次？那么比较一下 基因组，我们会问，“哪些基因没有在任何 所研究的基因组，哪些重复基因是不同基因组共同的，哪些是 仅限于特定的进化谱系？为什么会这样呢？ 是不是分发的？“ 4.研究基因组中的基因复制率。 5.研究复制基因的进化机制或复制方式 基因在复制事件之后进化。我们将研究各种型号。 用于重复基因的保留和进化。

DESCRIPTION (provided by applicant): Our goal is to understand the process and mechanisms of the evolution of duplicate genes in eukaryotic genomes. Several eukaryotic genomes have been completed and several more are soon to be completed. The huge amounts of genomic sequence data are very useful for studying various aspects of the evolution of duplicate genes. This is the first time that evolution of duplicate genes can be studied at the genomic level. To seize this unprecedented opportunity, we propose to pursue the following studies: 1. To develop methods for detecting duplicate genes in a genome and for classifying proteins into families. 2. To develop methods for detecting block duplications in a genome. A computer software package for the methods in (1) and (2) will be developed. 3. To assess the extents of gene duplication in various eukaryotic genomes. For each complete genome we ask: How many duplicate genes (gene families) exist in the genome? How often block duplication occurs? Then in comparison among genomes, we shall ask, "which genes have not been duplicated in any of the genomes studied, which duplicate genes are common to diverse genomes and which are restricted to only certain evolutionary lineages? And why are they so distributed?" 4. To study the rate of gene duplication in a genome. 5. To study the mechanisms of evolution of duplicate genes or how duplicate genes evolve following the duplication event. We shall examine various models for the retention and evolution of duplicate genes.