The effect of internal droplet crystallisation on the drying process of Alpha Olefin Sulfonate

内部液滴结晶对α-烯烃磺酸盐干燥过程的影响

• 批准号: 2597409
• 金额: --
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2597409
• 关键词: effect; internal; droplet; crystallisation; drying

Aims: The research aims to establish correlations between surfactant phase behaviour (AOS) and the solid-state structure of the dried droplet, with the latter strongly influencing product performance. New insights regarding structure-performance relationships will be determined that enable the controlled design of spray dried products. Project objectives include: Develop methods to study single droplet and multiple droplets drying with the purpose of demonstrating consistency at different processing scales. Determine the relationship between the components of alpha olefin sulphonate and the drying process. Demonstrate use of the single droplet drying method to determine the surfactant phase evolution during droplet drying. Develop correlations that enable the predictability of spray drying performance at scale. Methodology Proposed:Droplet drying: Two methods of drying will be considered: i) single droplet drying using levitating/filament droplet apparatus and ii) lab-scale (L) spray drying column. These methods will be used to determine the role of process parameters (temperature, air flow rate, drop size, surfactant concentration) on the resultant structure of the dried surfactant droplet. The single droplet apparatus will enable structure characterization during drying, with the end-state correlated to that observed in the spray drying column. Principal component analysis will be undertaken to determine the overriding factors that are influencing the drying process. Surfactant chemistry: The phase behaviour and relationship of isomers, impurities and additional components will be investigated and their role within the system analysed to deepen understanding of the chemistry. The relationship between solid-state structure, particle morphology and performance will be correlated. Materials characterization: SAXS will be used to study surfactant structure during droplet drying as the material crystallizes to form the solid-state structure. Surfactant phases will be further interrogated using cross-polarized microscopy, and the liquid and solid phases studied using SEM, particle size analysis, rheology and dissolution testing. Model development: Working within the parameter space, empirical/theoretical models will be developed to enable the prediction of the spray drying performance at scale, linking the physicochemical and process parameters to achieve the desired solid-state structure for optimal product performance. Potential Impact of Proposed Project (up to 200 Words) Provide detail regarding significance of the proposed project in terms of its potential for either industrial and/or economic/societal impact While many materials are spray dried, little is known about the phase transitions that occur when surfactant-laden droplets are dried to form the final product. It is hypothesized that those phase transitions are sensitive to the physicochemical properties of the system, and through greater insight, better control on the drying process and the final solid-state structure can be achieved. Currently only the input and output properties are measured, but with knowledge of the structural phase changes, system parameters can be tuned to deliver optimal product performance, ensuring product consistency, reducing waste, and eliminating the need for substantial trial-and-error activities to begin spray drying projects. Expected Deliverables:A better understanding of surfactant phase structure on drying kinetics and resultant solid-state structure. A method to follow from single drop to spray dried that is repeatable for other surfactants. A new mechanistic model, which would act as a predictive tool for large-scale spray drying operations.

目的：本研究旨在建立表面活性剂相行为(AOS)与干燥液滴的固态结构之间的关联，后者强烈地影响产品的性能。关于结构-性能关系的新见解将被确定，以实现喷雾干燥产品的受控设计。项目目标包括：开发研究单液滴和多液滴干燥的方法，目的是证明在不同处理规模下的一致性。确定了α-烯烃磺酸盐的组成与干燥过程的关系。演示了使用单液滴干燥方法来确定液滴干燥过程中表面活性剂的相演变。建立关联式，使喷雾干燥的规模化性能具有可预测性。建议的方法：液滴干燥：将考虑两种干燥方法：i)使用悬浮/丝状液滴装置进行单液滴干燥；ii)实验室规模(L)喷雾干燥柱。这些方法将用于确定工艺参数(温度、空气流量、液滴大小、表面活性剂浓度)对干燥表面活性剂液滴的最终结构的影响。单液滴装置将使干燥过程中的结构表征成为可能，其末端状态与在喷雾干燥柱中观察到的相关联。将进行主成分分析，以确定影响干燥过程的主要因素。表面活性剂化学：将研究异构体、杂质和其他组分的相行为和关系，并分析它们在体系中的作用，以加深对化学的理解。固体结构、颗粒形态和性能之间的关系将是相关的。材料表征：SAXS将用于研究液滴干燥过程中的表面活性剂结构，因为材料结晶形成固态结构。将使用交叉偏振显微镜进一步研究表面活性剂相，并使用扫描电子显微镜、粒度分析、流变学和溶解测试来研究液体和固体相。模型开发：在参数空间内，将开发经验/理论模型，以实现规模化喷雾干燥性能的预测，将物理化学参数和工艺参数联系起来，以实现所需的固态结构，以实现最佳产品性能。拟议项目的潜在影响(最多200字)详细说明了拟议项目对工业和/或经济/社会的潜在影响。虽然许多材料都是喷雾干燥的，但人们对携带表面活性剂的液滴干燥形成最终产品时发生的相变知之甚少。假设这些相变对体系的物理化学性质很敏感，通过更深入的了解，可以更好地控制干燥过程和最终的固态结构。目前只测量输入和输出属性，但在了解结构阶段变化的情况下，可以调整系统参数以提供最佳的产品性能，确保产品一致性，减少浪费，并消除启动喷雾干燥项目所需的大量反复试验活动。预期成果：更好地了解表面活性剂的相结构对干燥动力学和生成的固态结构的影响。一种从单滴到喷雾干燥的方法，可用于其他表面活性剂。一个新的机理模型，它将作为大规模喷雾干燥操作的预测工具。