Collagen for Medical Materials

医用材料用胶原蛋白

• 批准号: 2597540
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2597540
• 关键词: Collagen; Medical; Materials

Collagen is central to a range of biomedical materials, but important questions remain as to the relationships between source, processing, structure, physical properties such as viscosity, pH and solubility, and cell response. Covalent linkages and chemical modification of acidic and basic groups in the structurally-sensitive cell-binding sequences of collagen influence biofunction. This project starts by exploring these fundamental relationships and the consequences for medical material design.

胶原蛋白是一系列生物医学材料的核心，但重要的问题仍然是来源，加工，结构，物理性质（如粘度，pH值和溶解度）和细胞反应之间的关系。胶原蛋白的结构敏感性细胞结合序列中酸性和碱性基团的共价键和化学修饰影响生物功能。该项目从探索这些基本关系和医疗材料设计的后果开始。