Epidemiologic Studies of Alcohol Use Disorders (ongoing)

酒精使用障碍的流行病学研究（正在进行）

• 批准号: 6909128
• 负责人: DEBORAH S HASIN
• 金额: $ 13.7万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6909128
• 关键词: alcoholism /alcohol abuse; behavioral /social science research tag; clinical research; cocaine; comorbidity; disease /disorder onset; drug abuse; epidemiology; family structure /dynamics; gene environment interaction; human subject; interview; longitudinal human study; major depression; marijuana abuse; mental disorders; motivation; population survey; psychological stressor; public health; questionnaires; racial /ethnic difference; socioenvironment; substance abuse related behavior

DESCRIPTION (provided by applicant): Alcohol abuse and dependence are significant public health problems in the U.S. and worldwide. Clarifying the causes for onset and chronicity of these problems is a high scientific priority, as is the development of practical, effective interventions. This is an application for a K05 Research Scientist Award for Deborah Hasin, Ph.D. The purpose is to provide 5 years of ongoing support for Dr. Hasin to continue and expand her leadership role in alcoholism research. This will be achieved through the K05 release from teaching and administrative duties, allowing Dr. Hasin to continue to concentrate on her research and mentoring, which is characterized by a very high level of scientific accomplishment and productivity. During the K05 award, Dr. Hasin proposes to continue her research program at Columbia University (Mailman School of Public Health, Department of Epidemiology and College of Physicians and Surgeons, Department of Psychiatry). Dr. Hasin's research has focused on four main areas. (1) The validity of concepts of alcohol use disorders in the general population and the natural history of those disorders. (2) The relationship of major depression to alcohol and drug use disorders. Dr. Hasin's work has answered some of the main questions in these two areas, and continues to address important remaining issues. (3) Gene-environment interaction. Israeli population subgroups differ in their exposures to drinking environments and in their drinking. By studying alcohol metabolizing genes, alcohol consumption, and dependence severity in recent Russian immigrants to Israel and other Israelis, Dr. Hasin has identified a unique opportunity to study specific genes under sharply contrasting environmental circumstances (background per capita alcohol consumption levels). Dr. Hasin's work in this area has been described as critical for future directions in gene-environment studies of alcohol. Dr. Hasin will also continue to develop a newer area. (4) Brief intervention for unsafe drinking among patients in HIV primary care. Dr. Hasin will conduct her multifaceted program of research with experts at Columbia University and elsewhere. The K05 plan also includes continued participation in national and international scientific activities, and expansion of Dr. Hasin's mentoring and science education. By releasing Dr. Hasin from other responsibilities, the K05 award will allow Dr. Hasin to maintain her outstanding level of contribution to the field of alcoholism research.

描述（由申请人提供）：酒精滥用和依赖是美国和世界范围内的重大公共卫生问题。澄清这些问题的发病和长期性的原因是一个高度的科学优先事项，因为是实际的，有效的干预措施的发展。这是Deborah Hasin博士的K 05研究科学家奖申请书。其目的是为哈辛博士提供5年的持续支持，以继续并扩大她在酗酒研究中的领导作用。这将通过K 05从教学和行政职责中解脱出来来实现，使Hasin博士能够继续专注于她的研究和指导，其特点是科学成就和生产力水平非常高。在K 05奖期间，哈辛博士建议继续她在哥伦比亚大学（梅尔曼公共卫生学院，流行病学系和内科医生和外科医生学院，精神病学系）的研究计划。哈辛博士的研究集中在四个主要领域。(1)一般人群中酒精使用障碍概念的有效性以及这些障碍的自然史。(2)抑郁症与酒精和药物使用障碍的关系。哈辛博士的工作回答了这两个领域的一些主要问题，并继续解决重要的遗留问题。(3)基因-环境相互作用以色列人口亚群在暴露于饮酒环境和饮酒方面各不相同。通过研究最近俄罗斯移民到以色列和其他以色列人的酒精代谢基因，酒精消费和依赖程度，哈辛博士发现了一个独特的机会，可以在截然不同的环境条件下研究特定的基因（背景人均酒精消费水平）。哈辛博士在这一领域的工作被描述为对酒精的基因-环境研究的未来方向至关重要。哈辛博士还将继续开发一个新的领域。(4)对艾滋病初级保健患者不安全饮酒的短暂干预哈辛博士将与哥伦比亚大学和其他地方的专家一起进行她的多方面研究计划。K 05计划还包括继续参与国家和国际科学活动，扩大哈辛博士的指导和科学教育。通过解除哈辛博士的其他职责，K 05奖将使哈辛博士能够保持她对酗酒研究领域的杰出贡献。