NEURAL MECHANISM OF ATTENTIONAL CONTROL AND SELECTION

描述：K 05高级科学家奖提案旨在提高 私家侦探的百分之研究工作的神经机制的研究， 人类的注意力过程注意力机制包括控制 自上而下（自愿）和自下而上（反射）的注意系统，以及 因为这些控制系统对感知过程施加的调节作用。 这项提案的目标是将联合收割机的心理物理措施， 电位（ERP）记录和功能性磁共振成像（fiviRI）， 健康人群和患者群体来研究注意机制。三 主要研究内容包括：（1）注意控制机制 被认为涉及各种大脑系统， 计算操作，然而，很少有证据表明特定的大脑系统， 不同的注意力功能。本书将探讨注意力 控制过程中的各种范例的功能和形式为基础的 使用ERP和事件相关fMRI研究皮层和皮层下系统的注意 分离与注意任务的特定方面相关的活动的方法 性能(2)注意力可以影响神经元的活动， 在视觉皮层处理，但很少有人知道这些 影响了感觉皮层，或者说， 由各种形式的基本（基于特征）和高阶调制 注意力选择（attentional selection）该提案将调查 基于特征和形式的选择性注意的功能特性 功能定义的视觉区域。(3)神经损伤会导致 注意力紊乱的症状目前的建议将调查注意力 大脑皮层病变患者的ERP处理， 对病人的神经心理学研究， 健康人的功能成像研究;这项研究将侧重于 注意力控制机制该提案的一个主题是综合利用 ERPs和功能磁共振成像提供注意过程的补充措施， 分别强调神经活动的时间和空间方面。这 该提案将允许P.I.投入更大的精力调查 注意力机制，并通过充分利用 PI的优势的新研究环境在杜克大学。赤字 注意力功能伴随精神和神经疾病， 因此，对大脑注意机制的基本机制的研究将 产生必要的核心知识，以描述，诊断和 治疗人类的这种疾病。

DESCRIPTION: This K05 Senior Scientist Award proposal is intended to enhance the P.I.'s percent research effort in studies of the neural mechanisms of attentional processes in humans. Attentional mechanisms include the control systems for top-down (voluntary) and bottom-up (reflexive) attention, as well as the modulatory effects these control systems exert on perceptual processes. The goal of this proposal is to combine psychophysical measures, event-related potential (ERP) recording and functional magnetic resonance imaging (fiviRI) in healthy and patient populations to investigate attentional mechanisms. Three main areas of investigation are proposed: (1) Attentional control mechanisms are proposed to involve a variety of brain systems that support different computational operations, yet, little evidence links specific brain system to distinct attentional functions. This proposal will investigate attentional control processes in a variety of paradigms for feature and form-based attention in cortical and subcortical systems using ERP and event-related fMRI methods to isolate activity related to specific aspects of attentional task performance. (2) It is now well accepted that attention can influence neuronal processing in visual cortex, but little is actually known about how these effects are engaged in sensory cortex, or how processing in early visual areas are modulated by various forms of elementary (feature-based) and higher-order (form-based) attentional selection. This proposal will investigate the functional properties of feature and form-based selective attention in functionally-defined visual areas. (3) Neurological damage leads to a variety of attentional disorders. The present proposal will investigate attentional processing in patients with cortical lesions using ERPs to provide a link between neuropsychological research in patients, and psychophysical and functional imaging studies in healthy persons; this research will focus on attentional control mechanisms. A theme of this proposal is the combined use of ERPs and fMRI to provide complementary measures of attentional processes that emphasize temporal and spatial aspects of neural activity, respectively. This proposal will permit the P.I. to dedicate greater effort toward investigating attentional mechanisms, and to advance research productivity by taking full advantage of the P.I.'s new research environment at Duke University. Deficits in attentional function accompany psychiatric and neurological diseases, and thus investigations of the basic mechanisms of brain attention mechanisms will yield essential core knowledge in the effort to characterize, diagnose and treat such conditions in humans.