CENTER FOR RESEARCH ON BOTANICAL DIETARY SUPPLEMENTS

描述：爱荷华州植物性膳食补充剂中心 大学(ISU)和爱荷华大学(UI)将传统上将两所大学联系起来 强大的互补机构，并将努力集中在重要的研究上 在植物补充剂上。这个多学科中心将包括科学家 从园艺，植物学，生物化学，分子生物学，毒理学， 化学、药物药理学、营养学、流行病学、临床医学 和统计数据。我们之所以选择研究松果菊和金丝桃属，是因为它们是 美国消费者最常用的两种草药；有 潜在健康益处的实质性证据；这两个属都很容易 在爱荷华州种植；以及我们附属的中北部地区植物引进 空间站维护着国家紫锥菊种质资源库，保存 该属所有已知的物种。这些草药还提供了不同的模型 对植物补充剂的研究和扩大我们对 草药的潜在健康益处。紫锥菊具有潜在的广泛生物活性 但人们对其活性成分知之甚少，也一无所知。 关于行动机制。相比之下，活性成分一直是 从金丝桃科植物中鉴定出来，并且有越来越多的关于机理的信息。这个 拟建中心包括五个项目和两个核心。项目1将重点放在 了解人类的遗传、发育和环境多样性 紫锥菊和金丝桃。项目2将提供对 标题松果菊属和金丝桃属植物的化学成分。项目3将寻求 了解松果菊和金丝桃的生物活性 负责关键成分的生物活性和生物利用度 人类受试者。项目4将进行饮食流行病学研究。 植物补充剂。项目5将在#年进行第一阶段和第二阶段的临床试验 艾滋病毒阳性者使用紫锥菊和金丝桃提取物。核心A， 种质和栽培，将提供已知的标准化植物材料 生物起源是在受控条件下产生的。规划和 行政核心(核心B)将促进中心的全面管理， 协调统计成分，加大膳食研究力度 通过提供发展资金和试点，在伊利诺伊州和执行支助股开展植物学研究 项目。该中心将作为国家资源，并与其他 机构。

DESCRIPTION: The Center on Dietary Botanical Supplements at Iowa State University (ISU) and the University of Iowa (UI) will link two traditionally strong complementary institutions and focus their effort on important research on botanical supplements. This multidisciplinary center will include scientists from horticulture, botany, biochemistry, molecular biology, oxicology, chemistry, medicinal pharmacology, nutrition, epidemiology, clinical medicine and statistics. We have chosen to study Echinacea and hypericum becase they are two of the most commonly used herbs by consumers in the united States; there is substantial evidence for potential health benefits; both genera are readily grown in Iowa; and our affiliated North Central Regional Plant Introduction Station maintains the national's germplasm repository for Echinacea, conserving all known species in the genus. These herbs also offer different models for research on botanical supplements and for expanding our understanding of the potential health benefit of herbs. Echinacea has potential broad bioactivity but little is known regarding the active constituents and nothing is known regarding mechanisms of action. In contrast, active constituents have been identified from hypericum and there is growing information on mechanism. The proposed center includes five projects and two cores. Project 1 will focus on understanding the genetic, developmental, and environmental diversity of Echinacea and Hypericum. Project 2 will provide the critical understanding of the chemical constituents in of Echinacea and Hypericum. Project 3 will seek to understand the bioactivity of Echinacea and Hypericum, the constituents responsible for bioactivity and the bioavailability of the key constituents in human subjects. Project 4 will conduct epidemiological studies of dietary botanical supplements. Project 5 will conduct phase 1 and II clinical trials in HIV positive subjects using extracts from Echinacea and Hypericum. Core A, germplasm and cultivation, will provide standardized plant materials of known biological origin produced under controlled conditions. The planning and administration Core (Core B) will facilitate overall management of the Center, coordinate the statistical component and increase research on dietary botanicals at UI and ISU through provision of development funds and pilot projects. This center will serve as a national resource and interact with other institutions.