CENTER FOR RESEARCH ON BOTANICAL DIETARY SUPPLEMENTS

描述：爱荷华州膳食植物补充剂中心 大学（ISU）和爱荷华州大学（UI）将连接两个传统的 强大的互补机构，并将精力集中在重要的研究上 植物补品这个多学科中心将包括科学家 从园艺学、植物学、生物化学、分子生物学、氧化学， 化学、药物药理学、营养学、流行病学、临床医学 和统计数据。我们选择研究紫锥菊和金丝桃，因为它们是 在美国消费者最常用的两种草药， 潜在的健康益处的大量证据;这两种属都很容易 生长在爱荷华州;和我们的附属北中部地区植物介绍 研究站维护着国家的紫锥菊种质库， 所有已知的物种。这些草药还提供了不同的模型， 植物补充剂的研究，并扩大我们对 草药的潜在健康益处。紫锥菊具有潜在的广泛生物活性 但对活性成分知之甚少， 关于行动机制。相比之下，活性成分已经被 从金丝桃属植物中鉴定出，其作用机制的信息越来越多。的 拟建中心包括五个项目和两个核心。项目1将侧重于 了解遗传、发育和环境多样性 紫锥花和金丝桃属。项目2将提供关键的理解， 紫锥菊属和金丝桃属植物的化学成分。项目3将寻求 了解紫锥菊和金丝桃的生物活性， 负责生物活性和生物利用度的关键成分， 人类实验对象项目4将进行流行病学研究， 植物补充剂项目5将进行第一阶段和第二阶段的临床试验， 使用紫锥花属和金丝桃属提取物的HIV阳性受试者。核心A， 种质和栽培，将提供已知的标准化植物材料 在受控条件下产生的生物来源。规划和 管理核心（核心B）将促进中心的全面管理， 协调统计部分，增加关于饮食的研究 通过提供发展资金和试点， 项目该中心将作为一个国家资源，并与其他 机构职能体系

DESCRIPTION: The Center on Dietary Botanical Supplements at Iowa State University (ISU) and the University of Iowa (UI) will link two traditionally strong complementary institutions and focus their effort on important research on botanical supplements. This multidisciplinary center will include scientists from horticulture, botany, biochemistry, molecular biology, oxicology, chemistry, medicinal pharmacology, nutrition, epidemiology, clinical medicine and statistics. We have chosen to study Echinacea and hypericum becase they are two of the most commonly used herbs by consumers in the united States; there is substantial evidence for potential health benefits; both genera are readily grown in Iowa; and our affiliated North Central Regional Plant Introduction Station maintains the national's germplasm repository for Echinacea, conserving all known species in the genus. These herbs also offer different models for research on botanical supplements and for expanding our understanding of the potential health benefit of herbs. Echinacea has potential broad bioactivity but little is known regarding the active constituents and nothing is known regarding mechanisms of action. In contrast, active constituents have been identified from hypericum and there is growing information on mechanism. The proposed center includes five projects and two cores. Project 1 will focus on understanding the genetic, developmental, and environmental diversity of Echinacea and Hypericum. Project 2 will provide the critical understanding of the chemical constituents in of Echinacea and Hypericum. Project 3 will seek to understand the bioactivity of Echinacea and Hypericum, the constituents responsible for bioactivity and the bioavailability of the key constituents in human subjects. Project 4 will conduct epidemiological studies of dietary botanical supplements. Project 5 will conduct phase 1 and II clinical trials in HIV positive subjects using extracts from Echinacea and Hypericum. Core A, germplasm and cultivation, will provide standardized plant materials of known biological origin produced under controlled conditions. The planning and administration Core (Core B) will facilitate overall management of the Center, coordinate the statistical component and increase research on dietary botanicals at UI and ISU through provision of development funds and pilot projects. This center will serve as a national resource and interact with other institutions.