Nanopore sensing of biomarkers in clinical samples using DNA origami nanostructures

使用 DNA 折纸纳米结构对临床样品中的生物标志物进行纳米孔传感

• 批准号: 2600505
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2600505
• 关键词: Nanopore; sensing; biomarkers; clinical; samples

Recent nanopore sensing studies have concentrated on receptor-modified carriers for selective nanopore sensing, and this new technique is emerging as a promising tool for disease diagnosis since it allows selective detection of target analytes in complex biological fluids. This project aims to design and construct a novel configuration changeable DNA origami carrier for single-molecule nanopore sensing of biomolecules. The general idea is that this DNA origami carrier can change its structure when bound with the target biomarkers. We will explore detection strategies for sensing biomarkers in clinical samples.

最近的纳米孔传感研究集中在受体修饰的载体上，用于选择性纳米孔传感，这种新技术正在成为一种有前途的疾病诊断工具，因为它允许在复杂的生物流体中选择性检测目标分析物。本研究旨在设计并构建一种新型的可改变构型的DNA折纸载体，用于生物分子的单分子纳米孔传感。一般的想法是，这种DNA折纸载体在与靶生物标志物结合时可以改变其结构。我们将探索用于感测临床样品中的生物标志物的检测策略。