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Near-infrared oximetry of breast tumors

乳腺肿瘤的近红外血氧定量法

基本信息

批准号：
6949682
负责人：
SERGIO FANTINI
金额：
$ 19.74万
依托单位：
TUFTS UNIVERSITY MEDFORD
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-21 至 2006-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6949682
关键词：
bioimaging /biomedical imaging breast neoplasm /cancer diagnosis breast neoplasms clinical research diagnosis design /evaluation female human subject infrared radiation mammography optics oximetry oxygen tension phantom model

项目摘要

DESCRIPTION (provided by applicant): Near-infrared mammography is a safe and painless breast imaging technique that is inherently sensitive to the hemoglobin concentration and oxygenation within the breast. The potential of this functional imaging technique for the detection of breast cancer has been explored for many decades with only partial success. The major limitation has been the qualitative nature of the oxygenation information provided by previous approaches to optical mammography. The broad objective of this application is to develop a new optical tool for functional breast imaging, which is aimed at discriminating benign and malignant breast lesions on the basis of a quantitative measurement of their oxygenation level. In the R21 Phase of this proposal, we intend to experimentally demonstrate the feasibility and the potential effectiveness of a novel spectral approach to optical mammography. To this aim, we plan to perform experimental tests on breast-like phantoms to simulate a quantitative measurement of the oxygen saturation of hemoglobin within breast lesions. The proposed approach is based on our quest for a robust oxygenation measurement of breast tumors that is insensitive to the high variability in the shape, size, and depth of the tumors. The basic hypothesis behind this proposal is that optical measurements at two optimal wavelengths, which are identified within the 680- 880 nm spectral band using a novel scheme of data analysis, can provide an accurate measurement of the tumor oxygenation. In the R33 Phase, we will implement the proposed spectral method into a practical instrument for breast imaging that is applicable to human subjects. This instrument will work in an optical transmission mode through the slightly compressed breast, and will measure two-dimensional projection images of the breast by means of a planar tandem scan of the illumination and collection optical fibers. Following preliminary tests of safety and technical performance, we will carry out a pilot study on human subjects to investigate the practical effectiveness of our proposed spectral approach. In particular, we will assess its potential in the detection and discrimination of benign and malignant breast tumors on the basis of their oxygenation levels. Our proposed approach to optical mammography has the potential to improve both the specificity and the sensitivity of current optical instruments, and it may open new opportunities in the area of breast cancer detection.

描述(由申请人提供)：近红外乳房X光摄影是一种安全、无痛的乳房成像技术，它对乳房内的血红蛋白浓度和氧合反应天生敏感。几十年来，人们一直在探索这种功能成像技术检测乳腺癌的潜力，但只取得了部分成功。主要的限制是由以前的光学乳房X光摄影方法提供的氧合信息的定性性质。这项应用的广泛目标是开发一种新的功能乳房成像的光学工具，旨在通过定量测量乳房病变的氧合水平来区分乳腺良恶性病变。在这项建议的R21阶段，我们打算通过实验证明一种新的光谱方法用于光学乳房X光照相的可行性和潜在的有效性。为此，我们计划在类似乳房的模体上进行实验测试，以模拟对乳房病变内血红蛋白氧饱和度的定量测量。所提出的方法是基于我们对乳腺肿瘤的强健的氧合测量的追求，该测量对肿瘤的形状、大小和深度的高度变异性不敏感。这一建议背后的基本假设是，使用一种新的数据分析方案在680-880 nm光谱范围内确定的两个最佳波长的光学测量可以提供对肿瘤氧合的准确测量。在R33阶段，我们将把提出的光谱方法应用到适用于人类受试者的实用乳房成像仪器中。该仪器将工作在光学传输模式下，通过轻微压缩的乳房，通过照明和采集光纤的平面串联扫描来测量乳房的二维投影图像。在安全和技术性能的初步测试之后，我们将在人类受试者身上进行一项初步研究，以调查我们建议的光谱方法的实际有效性。特别是，我们将根据乳房肿瘤的氧合水平来评估其在检测和鉴别乳腺良恶性肿瘤方面的潜力。我们提出的光学乳房X光摄影方法有可能提高目前光学仪器的特异性和灵敏度，并可能在乳腺癌检测领域开辟新的机会。