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Coherent hemodynamics spectroscopy for cerebral autoregulation and blood flow

用于脑自动调节和血流的相干血流动力学光谱

基本信息

批准号：
9921500
负责人：
SERGIO FANTINI
金额：
$ 50.22万
依托单位：
TUFTS UNIVERSITY MEDFORD
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-15 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9921500
关键词：
Acute Age Aging Aneurysmal Subarachnoid Hemorrhages Biomedical Engineering Blood Volume Blood capillaries Blood flow Brain Brain Mapping Cardiopulmonary Bypass Cerebral Ischemia Cerebrovascular Circulation Cerebrum Chronic Clinical Clinical Management Comparative Study Critical Care Data Data Analyses Development Dialysis procedure Diffuse Discrimination Disease Effectiveness Frequencies Hemodialysis Homeostasis Impaired cognition Impairment Interdisciplinary Study Ischemic Stroke Licensing Measurement Measures Medical Medical center Methods Microcirculation Modeling Monitor Near-Infrared Spectroscopy Neurocognitive Neurologic Neurologist Neurology Optical Methods Patients Peer Review Perfusion Physiological Procedures Protocols documentation Publications Regulation Reporting Reproducibility Research Spectrum Analysis Sphygmomanometers Stroke Subarachnoid Hemorrhage Techniques Technology Testing Therapeutic Intervention Thigh structure Time Tissue imaging Tissues Translating Traumatic Brain Injury Venous base blood flow measurement brain tissue cerebral hemodynamics cerebrovascular cerebrovascular disorder diagnosis diabetic diabetic patient diffuse optical spectroscopy and imaging hemodynamics high risk hypoperfusion improved innovation instrument mathematical model neurovascular new technology novel patient population pressure public health relevance research clinical testing success tool

项目摘要

Project Summary: This project aims to develop a novel non-invasive technique, coherent hemodynamics spectroscopy (CHS), for the local measurement of brain perfusion and autoregulation at the microvascular level. This new technique consists of three components: (1) An experimental method based on diffuse near- infrared spectroscopy (NIRS) to non-invasively collect brain perfusion data at the microcirculation level; (2) Mild perturbations in the systemic mean arterial pressure to evoke oscillations or transients in the cerebral hemodynamics; (3) The application of a new hemodynamic model to translate NIRS measurements of cerebral hemodynamics into measurements of physiological and functional quantities. Specifically, this proposal focuses on CHS measurements of dynamic cerebral autoregulation (dCA) and capillary transit time (CTT), which yields absolute cerebral blood flow (CBF). The capability of CHS to measure local CTT, CBF, and dCA will be capitalized by developing spatially-resolved CHS (for brain mapping) and depth-resolved CHS (for discrimination of extracerebral and brain tissues). We plan clinical tests at two units at the Tufts Medical Center, namely the dialysis unit and the neurological critical care unit, to demonstrate the clinical potential of CHS. The first clinical test, on diabetic hemodialysis patients, aims to validate CHS measurements of CBF and dCA in a comparative study with age-matched healthy controls, and to demonstrate the potential of CHS to detect a reduction in cerebral perfusion during hemodialysis. The second clinical test, on patients who suffered from aneurysmal Subarachnoid Hemorrhage (aSAH) and Traumatic Brain Injury (TBI), will directly test the clinical potential of CHS in monitoring cerebral perfusion and autoregulation deficits. The broad objective of this application is the development of a new tool for the quantitative, non-invasive assessment of local cerebrovascular hemodynamics at the microcirculation level. CHS offers a significant clinical potential as a result of its ability to non-invasively assess and monitor brain tissue perfusion, which is impaired in a variety of clinical conditions, including subarachnoid hemorrhage, traumatic brain injury, hemodialysis treatment, ischemic stroke, and cardiopulmonary bypass.

项目概述：该项目旨在开发一种新的非侵入性技术，即相干血流动力学光谱学(CHS)，用于局部测量脑血流灌注和微血管的自动调节水平。这一新技术由三部分组成：(1)基于漫射近距离的实验方法。红外光谱(NIRS)无创收集微循环水平的脑血流灌注数据；(2)轻度体循环平均动脉压的扰动引起脑部的振荡或瞬变血流动力学；(3)新的血流动力学模型在脑NIR测量中的应用血流动力学转变为生理和功能量的测量。具体地说，这个提案重点是动态脑自动调节(DCA)和毛细血管通过时间(CTT)的CHS测量，这产生了绝对脑血流量(CBF)。CHS测量本地CTT、CBF和DCA的能力将通过开发空间分辨的CHS(用于脑成像)和深度分辨的CHS(用于脑外和脑组织的辨别)。我们计划在塔夫茨医疗中心的两个单元进行临床测试，即透析病房和神经重症监护病房，以展示慢性阻塞性肺病的临床潜力。这个第一项临床试验是针对糖尿病血液透析患者，旨在验证CHS测量的CBF和DCA在与年龄匹配的健康对照组的比较研究，并展示CHS检测A 血液透析期间脑灌注量减少。第二项临床测试，针对患有动脉瘤性蛛网膜下腔出血(ASAH)和创伤性脑损伤(TBI)，将直接考验临床 CHS在监测脑血流灌注和自我调节缺陷方面的潜力。这样做的总体目标是应用程序是开发一种新的工具，用于定量、非侵入性评估局部微循环水平的脑血管血流动力学。CHS作为一种具有巨大临床潜力的其结果是它能够非侵入性地评估和监测脑组织灌注，这在各种疾病中都受到损害临床情况，包括蛛网膜下腔出血，创伤性脑损伤，血液透析治疗，缺血性中风和体外循环。