Near-infrared spectral imaging of the breast for cancer detection and monitoring

用于癌症检测和监测的乳腺近红外光谱成像

• 批准号: 8191273
• 负责人: SERGIO FANTINI
• 金额: $ 46.44万
• 依托单位: TUFTS UNIVERSITY MEDFORD
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-12 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8191273
• 关键词: Area; Benign; Breast; Breast Cancer Detection; Cancer Detection; Cancer Diagnostics; Clinical; Collection; Data; Detection; Development; Discrimination; Effectiveness; Engineering; Female breast; Hemoglobin; Human; Image; Lesion; Light; Lipids; Malignant - descriptor; Malignant Neoplasms; Mammary Gland Parenchyma; Mammary Neoplasms; Mammography; Maps; Medical center; Methods; Monitor; Neoadjuvant Therapy; Optical Instrument; Optics; Outcomes Research; Oxygen saturation measurement; Pattern; Phase; Reproducibility; Research; Research Activity; Resolution; Sampling; Scanning; Scheme; Spatial Distribution; Testing; Time; Tissues; Treatment Efficacy; Water; Work; analytical tool; base; breast lesion; cancer regression; cancer therapy; chromophore; clinical application; clinical practice; design; hemodynamics; image reconstruction; imaging modality; in vivo; instrument; instrumentation; interest; malignant breast neoplasm; novel; optical imaging; prototype; reconstruction; research and development; response; tool; tumor progression

DESCRIPTION (provided by applicant): This project involves (1) the development of a novel instrument for optical imaging of the human breast, and (2) pilot clinical tests to demonstrate the effectiveness of the proposed instrument in detecting breast cancer and monitoring response to neoadjuvant therapy of breast cancer. The proposed instrument features levels of spatial sampling (25 points/cm2 on the x-y scanning plane), spectral sampling (0.5 points/nm over the wavelength band 650-1000 nm), and temporal resolution (20 full spectra/s) that are not simultaneously achieved by any existing optical mammography instrument. These instrumentation capabilities will be used to enhance the information content of optical mammograms in terms of spatial information (depth discrimination, tomographic reconstruction of hemoglobin/water/lipid/scattering-parameters distributions), quantitative oximetry, and temporal hemodynamics characterization. The planned clinical tests will specifically test the hypothesis that intrinsic optical contrast provided by hemoglobin, water, lipids, and scattering parameters in breast tissue allows for the detection of breast cancer, its discrimination from benign breast lesions, and for monitoring effectiveness of neoadjuvant breast cancer therapy. The broad objective of this application is the development of optical mammography as a stand-alone clinical tool for breast cancer detection, and for monitoring effectiveness of therapy. PUBLIC HEALTH RELEVANCE: This research can open new opportunities for clinical practice in the areas of breast cancer detection and prediction of response to treatment. In fact, the proposed instrument for optical imaging of the breast provides functional information (hemodynamics, oxygenation, water/lipids distribution, etc.) that is complementary to the information provided by existing clinical imaging modalities, thus potentially enhancing detection of breast cancer and its discrimination from benign lesions. Furthermore, because the proposed instrument uses safe levels of non-ionizing near-infrared light, it allows for repeated breast examinations on a weekly or even daily basis for continuous monitoring of breast cancer progression or regression.

描述(申请人提供)：该项目涉及(1)开发一种新的人体乳房光学成像仪器，以及(2)试点临床测试，以证明建议的仪器在检测乳腺癌和监测乳腺癌新辅助治疗的反应方面的有效性。该仪器具有空间采样水平(x-y扫描平面上的25点/cm2)、光谱采样水平(650-1000 nm波段上的0.5点/nm)和时间分辨率(20全光谱/S)，这些都是现有的光学乳房X光照相仪无法同时实现的。这些仪器功能将用于在空间信息(深度辨别、血红蛋白/水/脂/散射参数分布的断层重建)、定量血氧仪和时间血流动力学表征方面增强光学乳房X光照片的信息含量。计划中的临床测试将专门测试这一假设，即由乳腺组织中的血红蛋白、水、脂类和散射参数提供的固有光学对比可以检测乳腺癌，将其与良性乳腺病变区分开来，并监测新辅助乳腺癌治疗的有效性。这一应用的广泛目标是开发光学乳房X光照相作为乳腺癌检测和监测治疗效果的独立临床工具。 公共卫生相关性：这项研究可以为乳腺癌检测和治疗反应预测领域的临床实践开辟新的机会。事实上，拟议中的乳房光学成像仪器提供了功能信息(血流动力学、氧合作用、水/脂分布等)。这是对现有临床成像模式提供的信息的补充，因此有可能加强对乳腺癌的检测及其与良性病变的区分。此外，由于建议的仪器使用安全水平的非电离近红外光，它允许每周甚至每天重复进行乳房检查，以持续监测乳腺癌的进展或消退。