Exercise and Fitness in Childhood Cancer Survivors

描述(由申请人提供) 本提案是根据RFA CA-04-03由一名新的调查员提交的。它概述了评估体育锻炼干预以改善年轻儿童癌症幸存者的身体健康和参与体育活动的试点研究(R21)。为这项研究聚集的研究人员团队将在儿科心理肿瘤学、儿科肿瘤学、儿科内分泌学和肿瘤学患者的健身锻炼方面贡献非凡的专业知识。我们假设，作为对儿童癌症幸存者的干预措施，体育锻炼计划将积极地影响他们对疾病及其治疗的身体和心理适应。与只接受健康和健身教育的对照组相比，接受干预和健康健身教育的受试者更有可能体验到更好的身体功能和更高的生活质量。预计这项干预措施将对与儿童癌症有关的几种长期疾病产生积极的变化，包括身体条件解除、肥胖、疲劳、相关的新陈代谢状况和心理调整问题。 本研究采用随机分组重复测量设计，分为干预条件(IC)和对照条件(CC)。将招募40名儿童癌症幸存者，他们被诊断为癌症的5年以上。20名受试者将被随机分配到IC或CC。分配给IC的受试者将接受为期12周的有氧运动和身体活动计划，以及健康和健身教育。CC受试者将只接受健康和健身教育。将在基线、治疗结束和治疗结束后3个月评估身体运动能力(VO2max)、参与体育活动和与健康相关的生活质量的主要结果。还将获得一些次要结果，包括代谢功能指数、体重/成分指数和心理适应指数。这项研究的数据将有助于对这一重要问题进行更明确、更大规模的研究。最终，这项研究将提供有关儿童癌症长期身体后遗症的重要信息，并将指导干预措施，以减轻这些后果，提高生活质量。

DESCRIPTION (provided by applicant) This proposal is submitted in response to RFA CA-04-03 by a new investigator. It outlines pilot research (R21) to evaluate a physical exercise intervention to improve young childhood cancer survivors' physical fitness and involvement in physical activity. The team of researchers assembled for this study will contribute exceptional expertise in pediatric psycho-oncology, pediatric oncology, pediatric endocrinology and fitness exercise in oncology patients. We hypothesize that the physical exercise program, offered as an intervention to young survivors of childhood cancer, will positively affect their physical and psychological adjustment to their disease and its treatment. Subjects who receive the intervention and health and fitness education will be more likely to experience better physical functioning and more improved quality of life than those enrolled in a control group who receive health and fitness education alone. It is anticipated that the intervention will produce positive changes in several of the long-term morbidities associated with childhood cancer, including physical deconditioning, obesity, fatigue, related metabolic conditions and problems in psychological adjustment. The study utilizes a randomized, between groups, repeated measures design, with an Intervention Condition (IC) and a Control Condition (CC). 40 young survivors of childhood cancer, 5+ years from their diagnosis will be recruited. 20 subjects will be randomly assigned to either the IC or the CC. Subjects assigned to the IC will receive a 12-week long aerobic exercise and physical activity program, coupled with health and fitness education. CC subjects will receive only the health and fitness education. Primary outcomes of physical exercise capacity (VO2max), involvement in physical activity and health-related quality of life will be assessed at baseline, end of therapy, and at 3 months after the end of therapy. A number of secondary outcomes including indices of metablolic function, body mass/composition, and psychological adjustment will also be obtained. Data from this study will be instrumental in development of a more definitive, large-scale study of this important issue. Ultimately, this research will provide vital information regarding the long-term physical sequelae of childhood cancer, and will direct interventions to mitigate these outcomes and enhance quality of life.