Social & Physical Activity of Childhood Cancer Survivors

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• 批准号: 6928126
• 负责人: Debra L Friedman
• 金额: $ 18.6万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-06 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6928126
• 关键词: academic achievement; actigraphy; adolescence (12-20); aerobic exercise; behavioral /social science research tag; blood cell count; body physical activity; brain neoplasms; child psychology; clinical research; fatigue; hemoglobin; human subject; human therapy evaluation; injury /disease stressor; leukemia; long term survivor; longitudinal human study; neoplasm /cancer therapy; patient oriented research; pediatric neoplasm /cancer; posttraumatic stress disorder; psychological adaptation; psychological aspect of cancer; psychotherapy; quality of life; questionnaires; social psychology

DESCRIPTION (provided by applicant): The objective of this pilot research is to further refine and evaluate a newly devised intervention to alter young cancer patients' capacity for, and level of involvement in, physical and social activity, and to begin to examine the extent to which this intervention will favorably affect long-term adjustment to cancer and its treatment. We hypothesize that the physical/social activity program we are developing, offered as an intervention to adolescents who have recently completed therapy for cancer, will positively affect their physical and psychological adjustment to their disease. Adolescents who receive the intervention will be more likely to experience better physical and social functioning, good quality of life and enhanced post-traumatic growth, and less likely to experience post-traumatic stress, than those who do not. Those who are required by nature of their disease, its treatment, or its physical and psychological sequelae to substantially reduce activity in either or both domains, and who do not receive the experimental intervention will have a greater likelihood of experiencing more negative outcomes, with declines in physical capacity/involvement and social involvement, a decreased quality of life and a greater likelihood of post-traumatic stress, as opposed to posttraumatic growth or resilience. The study utilizes a randomized, between groups, repeated measures design, with an Intervention Condition (1C) and a Control (standard care/wait list) Condition (CC). An initial development phase involving six subjects will allow further refinement of the intervention and measures, prior to start of the intervention trial. For the intervention trial, 44 12-16 year old youths, at the end of their treatment for leukemia or brain tumors will be recruited. Using a randomized, between-groups, repeated measures design, 22 subjects will be randomly assigned to either the Intervention or the Control Condition. Subjects assigned to the 1C will receive a 12-week long aerobic exercise and physical activity program and will receive training in social skills, provided to groups of four-six. A multi-informant, multi-method assessment of both physical and social activity will be obtained at Baseline, at the end of the intervention, and at three3-month follow-up during both the development and intervention phases. Assessments will include self- and parent-proxy ratings of physical and social functioning, objective and self-report measures of activity level, cardiopulmonary exercise testing and hemoglobin/hematocrit levels. Self- and parent-proxy ratings of post-traumatic stress symptoms, posttraumatic growth and quality of life will also be obtained, as indicators of both positive and negative adjustment to their disease. Subjects in the 1C will be compared to an equal number of subjects enrolled in a standard care CC on identical outcome measures.

描述（由申请人提供）： 这项试点研究的目的是进一步完善和评估一种新设计的干预措施，以改变年轻癌症患者的身体和社会活动的能力和参与水平，并开始检查这种干预措施将在多大程度上有利地影响癌症及其治疗的长期调整。 我们假设，我们正在开发的身体/社会活动计划，作为对最近完成癌症治疗的青少年的干预，将积极影响他们对疾病的身体和心理调整。接受干预的青少年将更有可能体验到更好的身体和社会功能，良好的生活质量和增强的创伤后成长，并且比那些没有接受干预的青少年更不可能经历创伤后压力。那些因其疾病、治疗或身心后遗症的性质而需要大幅减少其中一个或两个领域活动的人，以及那些没有接受实验性干预的人，更有可能经历更多的负面结果，身体能力/参与和社会参与下降，生活质量下降，更有可能出现创伤后应激反应，而不是创伤后成长或恢复力。 本研究采用随机化、组间重复测量设计，包括干预条件（1C）和对照（标准治疗/等待名单）条件（CC）。在干预试验开始之前，涉及6名受试者的初始开发阶段将允许进一步完善干预和措施。对于干预试验，将招募44名12-16岁的青少年，在他们的白血病或脑肿瘤治疗结束时。采用随机、组间、重复测量设计，将22例受试者随机分配至干预组或对照组。被分配到1C的受试者将接受为期12周的有氧运动和体育活动计划，并将接受社交技能培训，提供给4 - 6人的小组。将在基线、干预结束时以及开发和干预阶段的3个月随访时对身体活动和社会活动进行多信息提供者、多方法评估。评估将包括身体和社会功能的自我和父母代理评级，活动水平的客观和自我报告测量，心肺运动测试和血红蛋白/红细胞压积水平。还将获得创伤后应激症状、创伤后成长和生活质量的自我和父母代理评级，作为对其疾病的积极和消极调整的指标。在相同的结局指标上，将1C中的受试者与标准治疗CC中入组的相同数量的受试者进行比较。