VOLT (Vanderbilt Oncology Training Program)

VOLT（范德比尔特肿瘤学培训计划）

• 批准号: 10554999
• 负责人: Debra L Friedman
• 金额: $ 35.79万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10554999
• 关键词: Oncology; Training Programs

PROJECT SUMMARY The overall goal of the Vanderbilt Oncology Training Program (VOLT) is to prepare hematology and oncology fellows and other trainees for careers conducting impactful cancer-related clinical, translational, and population science. The objectives of VOLT are 1) to identify and recruit trainees to become top-tier junior investigators in hematology and oncology by providing an advanced training experience, 2) to develop skills that support this career, including communication, resiliency, team building, and grant management, and 3) to educate trainees on the importance and incorporation of diversity, equity, and inclusion (DEI), and community outreach and engagement (COE) into their research and clinical practice. VOLT will accomplish this by mentored clinical research in oncology and tailored didactics including Master’s degree programs. Through regular meetings with the Program Directors, peer trainees, and mentorship committees, annual retreats, as well as preparation of Individual Development Plans and structured Progress Reports, VOLT trainees gain the skill set required for a successful oncology research career. VOLT has identified a diverse group of 43 committed, experienced mentors across cancer-related disciplines. Trainees conduct mentored research in three areas: 1) molecular oncology, 2) therapeutic development, tumor immunology, and immunotherapy, and 3) bioinformatics, big data, and cancer outcomes. Trainees are recruited from medical and pediatric hematology and oncology, or other cancer-related disciplines. VOLT is led by two physician scientists, a medical oncologist who conducts translational research and a pediatric oncologist who conducts population science and clinical research. An Internal Advisory Committee representing the diversity of VOLT research evaluates prospective trainees, and monitors the progress of individual trainees and the program’s success. Metrics for trainee and program evaluation include diversity of program participants, program completion, retention in research-focused careers, funding success, publication, and impact. An External Advisory Committee, composed of four physician-scientists, provides input into the scientific direction of program, ensures it is meeting national workforce needs and cancer priorities, and monitors progress, accomplishments, and trajectory to further programmatic advancement. Ongoing program evaluation has led to improvements in trainee evaluation, minority recruitment strategies, training in DEI and COE and mentoring, and changes in advisors and mentors to reflect greater diversity. Our 10 trainees have published 28 manuscripts since their appointment to VOLT. Four have received peer-reviewed grant support, and an additional three have applications under review. Of the five trainees who have graduated, four continue in research-intensive careers. In its first cycle, VOLT has been successful in developing trainees who will lead cancer research and advance cancer care and is well poised to continue this trajectory.

项目摘要 范德比尔特肿瘤学培训计划（VOLT）的总体目标是准备血液学和肿瘤学 研究员和其他学员从事有影响力的与癌症相关的临床，翻译和 人口科学。 Volt的目标是1）识别和招募受训者成为顶级初中 血液学和肿瘤学研究人员通过提供高级培训经验，2）发展技能 支持这一职业，包括沟通，弹性，团队建设和赠款管理以及3） 教育受训者关于多样性，公平和包容（DEI）的重要性和公司，以及 社区宣传和参与（COE）进入他们的研究和临床实践。伏特将完成 这是通过指导肿瘤学和量身定制的教学疗法的指导性研究，包括硕士学位课程。 通过与计划董事，同伴学员和精通委员会的定期会议，年度 务虚会以及个人发展计划和结构化进度报告的准备，Volt 受训者获得了成功的肿瘤学研究职业所需的技能。 Volt已经确定了潜水员 在与癌症相关的学科中，有43个经验丰富的导师组成的小组。学员的指导 在三个领域的研究：1）分子肿瘤学，2）治疗发育，肿瘤免疫学和 免疫疗法和3）生物信息学，大数据和癌症结果。学员是从医疗中招募的 小儿血液学和肿瘤学或其他与癌症相关的学科。 Volt由两名医生领导 科学家，一名医学肿瘤学家，进行转化研究和一名儿科肿瘤学家 人口科学与临床研究。代表Volt多样性的内部咨询委员会 研究评估了潜在的学员，并监视了个别学员的进步和计划的进步 成功。学员的指标和计划评估包括计划参与者的多样性，计划 完成，以研究为重点的职业保留，资金成功，出版和影响力。外部 由四个身体科学家组成的咨询委员会提供了指向科学方向的意见 计划，确保它可以满足国家劳动力需求和癌症的优先事项，并监视进展， 成就和轨迹，以进一步的程序化进步。正在进行的计划评估领导 为了改善受训者评估，少数族裔招聘策略，在DEI和COE和心理方面的培训， 以及顾问和导师的变化，以反映更大的多样性。我们的10名学员已经出版了28 手稿被任命为Volt。四个已获得同行评审的赠款支持，一个 另外三个申请正在审核中。在毕业的五名学员中，有四名继续 研究密集型职业。在第一个周期中，Volt成功地开发了将领导的培训 癌症研究和进步癌症护理，并有充分的中毒，可以继续这种轨迹。

项目成果

High Sensitivity Troponin T and NT-proBNP in Patients Receiving Chimeric Antigen Receptor (CAR) T-Cell Therapy.

• DOI: 10.2991/chi.k.210718.001
• 发表时间: 2021-09
• 期刊: Clinical hematology international
• 作者: Hu JR;Patel A;Huang S;Su YR;Dahlman KB;Tomasek K;Zhang Y;O'Neil RT;O'Neal JF;Turker I;Johnson DB;Salem JE;Moslehi JJ;Oluwole O
• 通讯作者: Oluwole O

Similar Outcomes in Early-Failure Steroid-Dependent Compared to Upfront Steroid Refractory Acute Graft-Versus-Host Disease Following Allogeneic Hematopoietic Cell Transplant.

• DOI: 10.14740/jh761
• 发表时间: 2021-03
• 期刊: Journal of hematology
• 影响因子: 1.2
• 作者: Patel DA;Mendoza KA;Chen H;Engelhardt BG;Savani BN;Goodman SA;Warner J;Kassim AA;Byrne M;Chinratanalab W;Greer JP;Hunt C;Jagasia M
• 通讯作者: Jagasia M

Abnormal Cardiac Repolarization After Seizure Episodes in Structural Brain Diseases: Cardiac Manifestation of Electrical Remodeling in the Brain?

结构性脑疾病癫痫发作后心脏复极异常：大脑电重塑的心脏表现？

• DOI: 10.1161/jaha.120.019778
• 发表时间: 2021-05-04
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Mori S;Hori A;Turker I;Inaji M;Bello-Pardo E;Miida T;Otomo Y;Ai T
• 通讯作者: Ai T

Minimal residual disease negativity and lenalidomide maintenance therapy are associated with superior survival outcomes in multiple myeloma.

• DOI: 10.1038/s41409-020-0791-y
• 发表时间: 2020-06
• 期刊: BONE MARROW TRANSPLANTATION
• 影响因子: 4.8
• 作者: Patel, Dilan A.;Gopalakrishnan, Ragisha;Engelhardt, Brian G.;McArthur, Evonne;Sengsayadeth, Salyka;Culos, Katie A.;Byrne, Michael;Goodman, Stacey;Savani, Bipin N.;Chinratanalab, Wichai;Jagasia, Madan;Mosse, Claudio A.;Cornell, Robert F.;Kassim, Adetola A.
• 通讯作者: Kassim, Adetola A.

Immune checkpoint inhibitors and their impact on liver enzymes and attenuation.

• DOI: 10.1186/s12885-022-10090-9
• 发表时间: 2022-09-20
• 期刊: BMC CANCER
• 影响因子: 3.8
• 作者: Park, Benjamin C.;Lee, Aaron X. T.;Ye, Fei;Turker, Isik;Johnson, Douglas B.
• 通讯作者: Johnson, Douglas B.