VOLT (Vanderbilt Oncology Training Program)

VOLT（范德比尔特肿瘤学培训计划）

• 批准号: 10554999
• 负责人: Debra L Friedman
• 金额: $ 35.79万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10554999
• 关键词: Oncology; Training Programs

PROJECT SUMMARY The overall goal of the Vanderbilt Oncology Training Program (VOLT) is to prepare hematology and oncology fellows and other trainees for careers conducting impactful cancer-related clinical, translational, and population science. The objectives of VOLT are 1) to identify and recruit trainees to become top-tier junior investigators in hematology and oncology by providing an advanced training experience, 2) to develop skills that support this career, including communication, resiliency, team building, and grant management, and 3) to educate trainees on the importance and incorporation of diversity, equity, and inclusion (DEI), and community outreach and engagement (COE) into their research and clinical practice. VOLT will accomplish this by mentored clinical research in oncology and tailored didactics including Master’s degree programs. Through regular meetings with the Program Directors, peer trainees, and mentorship committees, annual retreats, as well as preparation of Individual Development Plans and structured Progress Reports, VOLT trainees gain the skill set required for a successful oncology research career. VOLT has identified a diverse group of 43 committed, experienced mentors across cancer-related disciplines. Trainees conduct mentored research in three areas: 1) molecular oncology, 2) therapeutic development, tumor immunology, and immunotherapy, and 3) bioinformatics, big data, and cancer outcomes. Trainees are recruited from medical and pediatric hematology and oncology, or other cancer-related disciplines. VOLT is led by two physician scientists, a medical oncologist who conducts translational research and a pediatric oncologist who conducts population science and clinical research. An Internal Advisory Committee representing the diversity of VOLT research evaluates prospective trainees, and monitors the progress of individual trainees and the program’s success. Metrics for trainee and program evaluation include diversity of program participants, program completion, retention in research-focused careers, funding success, publication, and impact. An External Advisory Committee, composed of four physician-scientists, provides input into the scientific direction of program, ensures it is meeting national workforce needs and cancer priorities, and monitors progress, accomplishments, and trajectory to further programmatic advancement. Ongoing program evaluation has led to improvements in trainee evaluation, minority recruitment strategies, training in DEI and COE and mentoring, and changes in advisors and mentors to reflect greater diversity. Our 10 trainees have published 28 manuscripts since their appointment to VOLT. Four have received peer-reviewed grant support, and an additional three have applications under review. Of the five trainees who have graduated, four continue in research-intensive careers. In its first cycle, VOLT has been successful in developing trainees who will lead cancer research and advance cancer care and is well poised to continue this trajectory.

项目摘要 范德比尔特肿瘤学培训计划（VOLT）的总体目标是为血液学和肿瘤学 研究员和其他学员的职业生涯进行有影响力的癌症相关的临床，翻译， 人口科学VOLT的目标是1）识别和招募学员成为顶级初级学员 通过提供先进的培训经验，2）培养血液学和肿瘤学研究者的技能 支持这一职业生涯，包括沟通，弹性，团队建设和赠款管理，以及3） 教育受训者了解多样性、公平和包容的重要性和融入，以及 社区外展和参与（COE）到他们的研究和临床实践。VOLT将实现 这是通过指导临床研究肿瘤学和量身定制的教学法，包括硕士学位课程。 通过与项目主管、同行学员和导师委员会定期举行会议， 务虚会，以及编制个人发展计划和结构化进度报告，VOLT 学员获得成功的肿瘤学研究生涯所需的技能。VOLT已经确定了一个多样化的 由43名致力于癌症相关学科的经验丰富的导师组成。受训人员的行为得到指导 在三个领域的研究：1）分子肿瘤学，2）治疗开发，肿瘤免疫学，和 免疫疗法，以及3）生物信息学，大数据和癌症结果。受训人员从医务人员中招募， 以及儿科血液学和肿瘤学或其他癌症相关学科。VOLT由两名医生领导 科学家，一名进行转化研究的医学肿瘤学家和一名进行 人口科学和临床研究。代表VOLT多样性的内部咨询委员会 研究评估未来的受训者，并监测个别受训者的进展和该计划的 成功培训生和计划评估包括计划参与者的多样性，计划 完成，保留在研究为重点的职业生涯，资助成功，出版，和影响。外部 咨询委员会由四名医生和科学家组成，为以下科学方向提供投入： 计划，确保它满足国家劳动力需求和癌症优先事项，并监测进展， 成就和进一步推进方案的轨迹。正在进行的项目评估导致 改进受训人员评价、少数族裔征聘战略、DEI和COE培训以及指导， 以及顾问和导师的变化，以反映更大的多样性。我们的10名学员发表了28篇 自被任命为VOLT以来的手稿。四个已获得同行评审的赠款支持，一个已获得同行评审的赠款支持 另有三项申请正在审查中。在五名已毕业的受训人员中，四名继续在 研究密集型职业。在其第一个周期，VOLT已成功地培养学员谁将领导 癌症研究和先进的癌症护理，并准备继续这一轨迹。

项目成果

High Sensitivity Troponin T and NT-proBNP in Patients Receiving Chimeric Antigen Receptor (CAR) T-Cell Therapy.

• DOI: 10.2991/chi.k.210718.001
• 发表时间: 2021-09
• 期刊: Clinical hematology international
• 作者: Hu JR;Patel A;Huang S;Su YR;Dahlman KB;Tomasek K;Zhang Y;O'Neil RT;O'Neal JF;Turker I;Johnson DB;Salem JE;Moslehi JJ;Oluwole O
• 通讯作者: Oluwole O

Similar Outcomes in Early-Failure Steroid-Dependent Compared to Upfront Steroid Refractory Acute Graft-Versus-Host Disease Following Allogeneic Hematopoietic Cell Transplant.

• DOI: 10.14740/jh761
• 发表时间: 2021-03
• 期刊: Journal of hematology
• 影响因子: 1.2
• 作者: Patel DA;Mendoza KA;Chen H;Engelhardt BG;Savani BN;Goodman SA;Warner J;Kassim AA;Byrne M;Chinratanalab W;Greer JP;Hunt C;Jagasia M
• 通讯作者: Jagasia M

Abnormal Cardiac Repolarization After Seizure Episodes in Structural Brain Diseases: Cardiac Manifestation of Electrical Remodeling in the Brain?

结构性脑疾病癫痫发作后心脏复极异常：大脑电重塑的心脏表现？

• DOI: 10.1161/jaha.120.019778
• 发表时间: 2021-05-04
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Mori S;Hori A;Turker I;Inaji M;Bello-Pardo E;Miida T;Otomo Y;Ai T
• 通讯作者: Ai T

Immune checkpoint inhibitors and their impact on liver enzymes and attenuation.

• DOI: 10.1186/s12885-022-10090-9
• 发表时间: 2022-09-20
• 期刊: BMC CANCER
• 影响因子: 3.8
• 作者: Park, Benjamin C.;Lee, Aaron X. T.;Ye, Fei;Turker, Isik;Johnson, Douglas B.
• 通讯作者: Johnson, Douglas B.

Minimal residual disease negativity and lenalidomide maintenance therapy are associated with superior survival outcomes in multiple myeloma.

• DOI: 10.1038/s41409-020-0791-y
• 发表时间: 2020-06
• 期刊: BONE MARROW TRANSPLANTATION
• 影响因子: 4.8
• 作者: Patel, Dilan A.;Gopalakrishnan, Ragisha;Engelhardt, Brian G.;McArthur, Evonne;Sengsayadeth, Salyka;Culos, Katie A.;Byrne, Michael;Goodman, Stacey;Savani, Bipin N.;Chinratanalab, Wichai;Jagasia, Madan;Mosse, Claudio A.;Cornell, Robert F.;Kassim, Adetola A.
• 通讯作者: Kassim, Adetola A.