Social & Physical Activity of Childhood Cancer Survivors

描述(由申请人提供)： 这项先导性研究的目的是进一步改进和评估一种新设计的干预措施，以改变年轻癌症患者的体力和社会活动能力和参与程度，并开始检查这种干预措施将在多大程度上有利于癌症及其治疗的长期适应。 我们假设，我们正在开发的身体/社会活动计划，作为对最近完成癌症治疗的青少年的干预，将积极影响他们对疾病的身体和心理适应。接受干预的青少年将比没有接受干预的青少年更有可能经历更好的身体和社会功能、良好的生活质量和创伤后成长增强，而不太可能经历创伤后应激障碍。那些由于其疾病、治疗或其生理和心理后遗症的性质而需要大幅减少其中一个或两个领域的活动的人，以及没有接受实验性干预的人，将更有可能经历更负面的结果，身体能力/参与和社会参与下降，生活质量下降，发生创伤后应激障碍的可能性更大，而不是创伤后的增长或复原力。 该研究采用随机分组重复测量设计，包括干预条件(1C)和对照(标准护理/等待名单)条件(CC)。涉及六个受试者的初步开发阶段将允许在干预试验开始之前进一步完善干预措施和措施。在干预试验中，将招募44名12-16岁的年轻人，在他们的白血病或脑瘤治疗结束时。采用随机、组间、重复测量设计，将22名受试者随机分配到干预组或对照组。被分配到1C的受试者将接受为期12周的有氧运动和身体活动计划，并将接受社交技能培训，提供给4-6人一组。将在基线、干预结束时以及在发展和干预阶段的三个月的3个月的跟踪中，对身体和社会活动进行多信息者、多方法的评估。评估将包括身体和社会功能的自我和家长代理评级，活动水平的客观和自我报告测量，心肺运动测试和血红蛋白/红细胞压积水平。还将获得创伤后应激症状、创伤后成长和生活质量的自我和父母代理评级，作为对其疾病进行积极和消极适应的指标。1C中的受试者将与在标准护理CC中登记的同等数量的受试者进行比较，结果相同。

DESCRIPTION (provided by applicant): The objective of this pilot research is to further refine and evaluate a newly devised intervention to alter young cancer patients' capacity for, and level of involvement in, physical and social activity, and to begin to examine the extent to which this intervention will favorably affect long-term adjustment to cancer and its treatment. We hypothesize that the physical/social activity program we are developing, offered as an intervention to adolescents who have recently completed therapy for cancer, will positively affect their physical and psychological adjustment to their disease. Adolescents who receive the intervention will be more likely to experience better physical and social functioning, good quality of life and enhanced post-traumatic growth, and less likely to experience post-traumatic stress, than those who do not. Those who are required by nature of their disease, its treatment, or its physical and psychological sequelae to substantially reduce activity in either or both domains, and who do not receive the experimental intervention will have a greater likelihood of experiencing more negative outcomes, with declines in physical capacity/involvement and social involvement, a decreased quality of life and a greater likelihood of post-traumatic stress, as opposed to posttraumatic growth or resilience. The study utilizes a randomized, between groups, repeated measures design, with an Intervention Condition (1C) and a Control (standard care/wait list) Condition (CC). An initial development phase involving six subjects will allow further refinement of the intervention and measures, prior to start of the intervention trial. For the intervention trial, 44 12-16 year old youths, at the end of their treatment for leukemia or brain tumors will be recruited. Using a randomized, between-groups, repeated measures design, 22 subjects will be randomly assigned to either the Intervention or the Control Condition. Subjects assigned to the 1C will receive a 12-week long aerobic exercise and physical activity program and will receive training in social skills, provided to groups of four-six. A multi-informant, multi-method assessment of both physical and social activity will be obtained at Baseline, at the end of the intervention, and at three3-month follow-up during both the development and intervention phases. Assessments will include self- and parent-proxy ratings of physical and social functioning, objective and self-report measures of activity level, cardiopulmonary exercise testing and hemoglobin/hematocrit levels. Self- and parent-proxy ratings of post-traumatic stress symptoms, posttraumatic growth and quality of life will also be obtained, as indicators of both positive and negative adjustment to their disease. Subjects in the 1C will be compared to an equal number of subjects enrolled in a standard care CC on identical outcome measures.