Social & Physical Activity of Childhood Cancer Survivors

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• 批准号: 7119695
• 负责人: Debra L Friedman
• 金额: $ 17.26万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-06 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7119695
• 关键词: academic achievement; actigraphy; adolescence (12-20); aerobic exercise; behavioral /social science research tag; blood cell count; body physical activity; brain neoplasms; child psychology; clinical research; fatigue; hemoglobin; human subject; human therapy evaluation; injury /disease stressor; leukemia; long term survivor; longitudinal human study; neoplasm /cancer therapy; patient oriented research; pediatric neoplasm /cancer; posttraumatic stress disorder; psychological adaptation; psychological aspect of cancer; psychotherapy; quality of life; questionnaires; social psychology

DESCRIPTION (provided by applicant): The objective of this pilot research is to further refine and evaluate a newly devised intervention to alter young cancer patients' capacity for, and level of involvement in, physical and social activity, and to begin to examine the extent to which this intervention will favorably affect long-term adjustment to cancer and its treatment. We hypothesize that the physical/social activity program we are developing, offered as an intervention to adolescents who have recently completed therapy for cancer, will positively affect their physical and psychological adjustment to their disease. Adolescents who receive the intervention will be more likely to experience better physical and social functioning, good quality of life and enhanced post-traumatic growth, and less likely to experience post-traumatic stress, than those who do not. Those who are required by nature of their disease, its treatment, or its physical and psychological sequelae to substantially reduce activity in either or both domains, and who do not receive the experimental intervention will have a greater likelihood of experiencing more negative outcomes, with declines in physical capacity/involvement and social involvement, a decreased quality of life and a greater likelihood of post-traumatic stress, as opposed to posttraumatic growth or resilience. The study utilizes a randomized, between groups, repeated measures design, with an Intervention Condition (1C) and a Control (standard care/wait list) Condition (CC). An initial development phase involving six subjects will allow further refinement of the intervention and measures, prior to start of the intervention trial. For the intervention trial, 44 12-16 year old youths, at the end of their treatment for leukemia or brain tumors will be recruited. Using a randomized, between-groups, repeated measures design, 22 subjects will be randomly assigned to either the Intervention or the Control Condition. Subjects assigned to the 1C will receive a 12-week long aerobic exercise and physical activity program and will receive training in social skills, provided to groups of four-six. A multi-informant, multi-method assessment of both physical and social activity will be obtained at Baseline, at the end of the intervention, and at three3-month follow-up during both the development and intervention phases. Assessments will include self- and parent-proxy ratings of physical and social functioning, objective and self-report measures of activity level, cardiopulmonary exercise testing and hemoglobin/hematocrit levels. Self- and parent-proxy ratings of post-traumatic stress symptoms, posttraumatic growth and quality of life will also be obtained, as indicators of both positive and negative adjustment to their disease. Subjects in the 1C will be compared to an equal number of subjects enrolled in a standard care CC on identical outcome measures.

描述（由申请人提供）： 该试点研究的目的是进一步完善和评估新设计的干预措施，以改变年轻癌症患者的身体和社会活动水平，并开始研究这种干预措施将对癌症及其治疗的长期调整的程度。 我们假设我们正在制定的身体/社会活动计划是为最近完成癌症治疗的青少年提供的一种干预，将对他们对疾病的身体和心理调整产生积极影响。接受干预的青少年将更有可能体验更好的身体和社交功能，良好的生活质量以及增强的创伤后成长，并且比没有那些没有的人更有可能经历创伤后压力。那些因其疾病本质，治疗或身体和心理后遗症而要求的人，可以大大减少任何一个或两个领域的活动，并且未接受实验干预的人会更有可能经历更多的负面结果，并且体能/参与和社会参与度的下降，生活的质量降低，并具有更大的生活质量和后果或背景。 这项研究利用了群体之间的随机重复测量设计，具有干预条件（1C）和对照（标准护理/等待列表）条件（CC）。涉及六个受试者的初始发展阶段将允许在开始干预试验之前进一步改进干预措施和措施。在干预试验中，将招募44名12-16岁的年轻人，在治疗白血病或脑肿瘤时。使用随机的组间，重复测量设计，将将22名受试者随机分配给干预条件或控制条件。分配给1C的受试者将获得一项为期12周的有氧运动和体育锻炼计划，并将接受为四六组提供的社交技能培训。在开发阶段和干预阶段，将在基线，干预结束时以及在三个月的随访中获得对身体和社会活动的多种信息评估。评估将包括对身体和社会功能的自我和父母评分，活动水平的客观和自我报告测量，心肺运动测试以及血红蛋白/血细胞比容水平。还将获得对创伤后应激症状，创伤后的生长和生活质量的自我和父母的评级，作为对其疾病的阳性和阴性调整的指标。在相同的结果指标中，将1C中的受试者与在标准护理CC中注册的受试者数量相等。