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Anti-inflammatory effects of Bromelain

Anti-inflammatory effects of Bromelain
菠萝蛋白酶的抗炎作用
批准号：
6860457
负责人：
Eric Richard Secor
金额：
$6.23万
依托单位：
UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
项目状态：
已结题
起止时间：
2004-02-23 至 2007-02-22
来源：
https://reporter.nih.gov/project-details/6860457
关键词：
alternative medicineantiinflammatory agentsbiotherapeutic agentcysteine endopeptidasescytokinedisease /disorder modeldosageenzyme linked immunosorbent assayflow cytometryhistologyimmunoglobulin Eimmunoglobulin Gimmunoregulationlaboratory mouselung lavagelymphocytenonhuman therapy evaluationnutrition related tagovalbuminplant extractspostdoctoral investigatorrespiratory disorderrespiratory disorder chemotherapyrespiratory functionspleen

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英文摘要
DESCRIPTION (provided by applicant): Investigate the anti-inflammatory (protease and immunoregulatory) effects of Bromelain, a commonly used nutritional supplement, in a mouse model of allergic airway disease. 1. Determine if Bromelain treatment alters lung function and/or pathophysiology in normal naive mice and in mice with OVA-induced allergic airway disease. 2. Investigate the mechanism(s) by which Bromelain treatment affects lung function and/or pathophysiology in normal mice and in mice OVA-induced allergic airway disease.
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