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Anti-inflammatory effects of Bromelain

Anti-inflammatory effects of Bromelain
菠萝蛋白酶的抗炎作用
批准号：
7022281
负责人：
Eric Richard Secor
金额：
$6.23万
依托单位：
UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
项目状态：
已结题
起止时间：
2004-02-23 至 2007-02-22
来源：
https://reporter.nih.gov/project-details/7022281
关键词：
alternative medicineantiinflammatory agentsbiotherapeutic agentcysteine endopeptidasescytokinedisease /disorder modeldosageenzyme linked immunosorbent assayflow cytometryhistologyimmunoglobulin Eimmunoglobulin Gimmunoregulationlaboratory mouselung lavagelymphocytenonhuman therapy evaluationnutrition related tagovalbuminplant extractspostdoctoral investigatorrespiratory disorderrespiratory disorder chemotherapyrespiratory functionspleen

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英文摘要
DESCRIPTION (provided by applicant): Investigate the anti-inflammatory (protease and immunoregulatory) effects of Bromelain, a commonly used nutritional supplement, in a mouse model of allergic airway disease. 1. Determine if Bromelain treatment alters lung function and/or pathophysiology in normal naive mice and in mice with OVA-induced allergic airway disease. 2. Investigate the mechanism(s) by which Bromelain treatment affects lung function and/or pathophysiology in normal mice and in mice OVA-induced allergic airway disease.
期刊论文(3)
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会议论文
Oral Bromelain Attenuates Inflammation in an Ovalbumin-induced Murine Model of Asthma.
DOI： 10.1093/ecam/nel110
发表时间： 2008-03
期刊： Evidence-based complementary and alternative medicine : eCAM
影响因子： --
作者： [Secor ER, Carson WF, Singh A, Pensa M, Guernsey LA, Schramm CM, Thrall RS]
通讯作者： Thrall RS
Tolerance induced by chronic inhaled antigen in a murine asthma model is not mediated by endotoxin.
在小鼠哮喘模型中，慢性吸入抗原诱导的耐受性不是由内毒素介导的。
DOI： 10.1016/j.bbadis.2006.02.002
发表时间： 2006
期刊： Biochimica et biophysica acta
影响因子： --
作者： [Schramm,CM, Guernsey,L, Secor,E, Thrall,RS]
通讯作者： Thrall,RS
The Effect of Bromelain on CD4+ T Cell Function in Asthma
The Effect of Bromelain on CD4+ T Cell Function in Asthma
The Effect of Bromelain on CD4+ T Cell Function in Asthma
The Effect of Bromelain on CD4+ T Cell Function in Asthma
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