Urodynamic and Multiethnic Variability of Men Treated b*

接受 b* 治疗的男性的尿动力学和多种族变异性

• 批准号: 7193905
• 负责人: STEVEN A KAPLAN
• 金额: --
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7193905
• 关键词: African American; Hispanic Americans; benign prostate hyperplasia; caucasian American; clinical trials; cooperative study; human subject; human therapy evaluation; hyperthermia therapy; laser therapy; male; outcomes research; patient oriented research; prognosis; racial /ethnic difference; urinary tract motility /pressure; urinary tract obstruction; urinary tract surgery; urination

DESCRIPTION (provided by applicant): Benign prostatic hyperplasia (BPH) is the most common affliction of men over the age of 50. Despite numerous innovations in therapy for BPH including medical and minimally invasive surgical therapies (MIST), transurethral resection of the prostate (TURP) remains the most effective. In part, the shortcomings of MIST have been the lack of uniform baseline study entry criteria, poor elucidation of baseline criteria aid in therapeutic success and paucity of long-term data. Furthermore, there have been no studies that have attempted to stratify response to therapy based on ethnic variability. Recent data suggests that there may be varying distribution of symptoms, objective diagnoses, and functional / morphologic aspects of the prostate among different ethnic groups. Do minimally invasive alternative surgical therapies result in alternating levels of success among different ethnic groups? The Prostate Center at the New York Presbyterian Medical Center evaluates and treats an ethnically diverse group of more than 1,000 men per year with lower urinary tract symptoms secondary to BPH. In addition it has access to and currently employs all FDA approved MIST procedures, including transurethral microwave thermotherapy, TUNA, interstitial laser, water induced thermotherapy, holmium laser prostatectomy and electrovaporization. We propose to examine the role of MISTs designed to treat BPH a multi - ethnic group. The goals of this clinical trial are to determine the urodynamic changes in bladder function and outlet obstruction in patients with BPH treated by MIST. Parameters to be analyzed include peak detrusor pressure during voiding, detrusor pressure during maximal flow, Shafer resistance curves, Abrams - Griffiths contractility index and detrusor contraction duration. These parameters will be assessed to determine prognostic significance and correlated with long term improvement as determined by changes in the American Urologic Association Symptom Score (AUASx), uroflow and post void residual urine. Specifically, this study aims to evaluate in a highly diverse multi - ethnic population: 1. Urodynamic contractility and resistance parameters which change significantly after MIST 2. Baseline urodynamic parameters which may predict improved outcome after MIST 3. The success of various types of MIST in treating BPH in African - American, Hispanic and Caucasian men.

描述(由申请人提供)： 良性前列腺增生症(BPH)是老年男性最常见的病症。 年仅50岁。尽管在治疗BPH方面有许多创新，包括 经尿道医学和微创手术疗法(MIST) 前列腺切除术(TURP)仍然是最有效的。在某种程度上， MIST的缺点是缺乏统一的基线研究条目 标准，对基线标准的解释不佳有助于治疗成功和 缺乏长期数据。此外，还没有研究表明 试图根据种族差异对治疗的反应进行分层。近期 数据表明，可能存在不同的症状分布，客观 前列腺的诊断和功能/形态方面的不同 种族群体。微创替代手术治疗是否会导致 不同种族之间的成功程度是不同的？ 纽约长老会医学中心的前列腺中心评估和 每年治疗1,000多名男性的种族多元化群体 继发于BPH的尿路症状。此外，它还可以访问和 目前采用FDA批准的所有MIST程序，包括经尿道 微波热疗，金枪鱼，间质激光，水诱导热疗， 钬激光前列腺切除术和电汽化术。我们建议研究 为治疗多种族群体的良性前列腺增生症而设计的雾的作用。这样做的目的是 临床试验是为了确定尿流动力学改变对膀胱功能和 雾化吸入治疗良性前列腺增生症出口梗阻参数应为 分析包括排尿时逼尿肌压力峰值、逼尿肌压力 在最大流量时，Shafer阻力曲线、Abrams-Griffiths收缩系数 指数和逼尿肌收缩持续时间。这些参数将被评估为 确定预后意义并与长期改善相关，如 由美国泌尿外科协会症状评分的变化决定 (AUASx)、尿流率和排尿后残余尿。 具体地说，这项研究旨在评估在高度多样化的多民族 人口： 1.变化的尿动力收缩和阻力参数 薄雾过后显著 2.可预测雾化后预后改善的基线尿动力学参数 3.各种类型的雾化疗法在治疗非裔美国人良性前列腺增生症方面的成功， 西班牙裔和高加索男性。