Urodynamic and Multiethnic Variability of Men Treated b*

描述（由申请人提供）： 良性前列腺增生（BPH）是男性最常见的疾病， 50岁。尽管在BPH治疗方面有许多创新， 药物和微创手术治疗（MIST），经尿道 前列腺切除术（TURP）仍然是最有效的。部分地 MIST的缺点是缺乏统一的基线研究条目 标准，基线标准说明不佳有助于治疗成功， 缺乏长期数据。此外，还没有研究表明， 试图根据种族差异对治疗反应进行分层。最近 数据表明，可能存在不同的症状分布，客观 诊断和功能/形态方面的前列腺之间的不同 种族群体。微创替代手术治疗是否会导致 在不同的种族群体中交替成功的水平？ 纽约长老会医疗中心的前列腺中心评估并 每年治疗1,000多名不同种族的男性， 前列腺增生的泌尿道症状此外，它还可以访问和 目前采用所有FDA批准的MIST程序，包括经尿道 微波热疗，TUNA，组织间激光，水诱导热疗， 钬激光前列腺切除术和汽化术。我们建议研究 MISTs在多种族人群中治疗BPH的作用。这个的目标 临床试验是为了确定膀胱功能的尿动力学变化， MIST治疗BPH患者的出口梗阻。的参数 分析包括排尿期间的逼尿肌压力峰值、逼尿肌压力 最大流量时，Shafer阻力曲线，Abrams-Griffiths收缩力 指数和逼尿肌收缩持续时间。将评估这些参数， 确定预后意义，并与长期改善相关， 根据美国泌尿外科协会症状评分的变化确定 （AUASx）、尿流和排尿后残余尿。 具体而言，本研究旨在评估在一个高度多样化的多民族 人口： 1.尿动力学收缩力和阻力参数发生变化 在MIST之后， 2.可预测MIST后结局改善的基线尿动力学参数 3.各种类型的MIST在非洲裔美国人中治疗BPH的成功， 西班牙裔和高加索人。

DESCRIPTION (provided by applicant): Benign prostatic hyperplasia (BPH) is the most common affliction of men over the age of 50. Despite numerous innovations in therapy for BPH including medical and minimally invasive surgical therapies (MIST), transurethral resection of the prostate (TURP) remains the most effective. In part, the shortcomings of MIST have been the lack of uniform baseline study entry criteria, poor elucidation of baseline criteria aid in therapeutic success and paucity of long-term data. Furthermore, there have been no studies that have attempted to stratify response to therapy based on ethnic variability. Recent data suggests that there may be varying distribution of symptoms, objective diagnoses, and functional / morphologic aspects of the prostate among different ethnic groups. Do minimally invasive alternative surgical therapies result in alternating levels of success among different ethnic groups? The Prostate Center at the New York Presbyterian Medical Center evaluates and treats an ethnically diverse group of more than 1,000 men per year with lower urinary tract symptoms secondary to BPH. In addition it has access to and currently employs all FDA approved MIST procedures, including transurethral microwave thermotherapy, TUNA, interstitial laser, water induced thermotherapy, holmium laser prostatectomy and electrovaporization. We propose to examine the role of MISTs designed to treat BPH a multi - ethnic group. The goals of this clinical trial are to determine the urodynamic changes in bladder function and outlet obstruction in patients with BPH treated by MIST. Parameters to be analyzed include peak detrusor pressure during voiding, detrusor pressure during maximal flow, Shafer resistance curves, Abrams - Griffiths contractility index and detrusor contraction duration. These parameters will be assessed to determine prognostic significance and correlated with long term improvement as determined by changes in the American Urologic Association Symptom Score (AUASx), uroflow and post void residual urine. Specifically, this study aims to evaluate in a highly diverse multi - ethnic population: 1. Urodynamic contractility and resistance parameters which change significantly after MIST 2. Baseline urodynamic parameters which may predict improved outcome after MIST 3. The success of various types of MIST in treating BPH in African - American, Hispanic and Caucasian men.