Fluorescent Imaging of Unstable Atherosclerotic Plaques in Blood Vessels

血管中不稳定动脉粥样硬化斑块的荧光成像

• 批准号: 2602056
• 金额: --
• 依托单位: University of Bath
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2602056
• 关键词: Fluorescent; Imaging; Unstable; Atherosclerotic; Plaques

ontext: The research carried out will consist of the optimization and further development of the classes of Diels-Alder reactions developed within the group previously, providing higher yields and larger scope of products. Some of these products will then be applied as fluorescent probes for cellular sensing for markers of disease such as atherosclerotic plaques and cancerous cells. Aim: To produce a theranostic agent capable of selectively releasing a drug molecule and a fluorescent marker upon contact with targeted markers of disease such as atherosclerotic plaques.Objectives:-Further optimise and develop the Diels-Alder reaction classes previously developed within the group to produce numerous varied aromatic scaffolds. -Target and produce a fluorescent probe capable of selective release in response to chosen disease markers utilising the developed Diels-Alder reactions.-Utilise fluorescent imaging assays to determine the responsiveness of the developed fluorescent probe to its targeted response conditions and measure the release of the drug molecule alongside this.Potential Applications and Benefits: -The further development of the Diels-Alder reaction classes which were previously identified within the group could allow for a more viable route to certain synthetic scaffolds. This could be of benefit within industry to produce potential pharmaceutical compounds more effectively.-The production of targeted theranostic agents could allow for the simultaneous identification and treatment of certain diseases such as coronary heart disease and cancers. This would provide a significant amount more information to do with the location of atherosclerotic plaques and cancerous cells whilst also treating these issues within a singular dose. This could be of great benefit to the health of society as a potentially highly effective early treatment/identification method for these diseases.Relevance to Research Council: This studentship is funded by the Engineering and Physical Sciences Research Council (EPSRC). The research undertaken will be of relevance to the EPSRC as it will yield developments within the physical sciences field (chemistry) with the potential to yield benefit to society through the production of more effective methods of treating and identifying life-threatening diseases.Relevance of Secondary Supervisor: Dr. Alex Cresswell has expertise within the field of pericyclic reactions and can provide flow apparatus for potential industrial applications of the research, making him highly useful in achieving my first two objectives.

上下文：所进行的研究将包括优化和进一步开发以前在该小组内开发的Diels-Alder反应类别，提供更高的产率和更大范围的产品。然后，这些产品中的一些将被用作荧光探针，用于疾病标记物（如动脉粥样硬化斑块和癌细胞）的细胞传感。目的：本发明涉及一种治疗诊断剂，其能够在与疾病的靶向标记物如动脉粥样硬化斑块接触时选择性地释放药物分子和荧光标记物。- 利用开发的Diels-Alder反应，靶向并产生能够响应所选疾病标记物选择性释放的荧光探针。利用荧光成像测定来确定所开发的荧光探针对其目标响应条件的响应性，并测量药物分子的释放。潜在应用和好处：-之前在该小组内确定的狄尔斯-阿尔德反应类别的进一步发展可以允许更可行的途径到达某些合成支架。这可能有利于工业更有效地生产潜在的药物化合物。靶向治疗诊断剂的生产可以同时识别和治疗某些疾病，如冠心病和癌症。这将提供更多关于动脉粥样硬化斑块和癌细胞位置的信息，同时也在单一剂量内治疗这些问题。作为这些疾病的潜在高效早期治疗/识别方法，这可能对社会健康有很大益处。与研究理事会的相关性：该奖学金由工程和物理科学研究理事会（EPSRC）资助。所进行的研究将与EPSRC相关，因为它将在物理科学领域内产生发展（化学）通过生产更有效的治疗和识别危及生命的疾病的方法，有可能造福社会。二级主管的相关性：Alex克雷斯韦尔博士在周环反应领域具有专业知识，并且可以提供流动装置用于本发明的潜在工业应用。他的研究，使他在实现我的前两个目标非常有用。