Development Of Cognitive Activation Tasks For Functional

功能性认知激活任务的开发

• 批准号: 6980323
• 负责人: Terry E Goldberg
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6980323
• 关键词: behavioral /social science research tag; bioimaging /biomedical imaging; brain circulation; catechol methyltransferase; cognition; genotype; human subject; magnetic resonance imaging; memory; neuroimaging; neurophysiology; neuropsychological tests; positron emission tomography; prefrontal lobe /cortex; psycholinguistics; schizophrenia; semantics

We have developed a variety of tasks to activate regions of interest in functional neuroimaging studies. 1. To examine the distinction between recall and familiarity in episodic memory function we have developed a task using visual scenes that reliably induces familiarity based errors in controls. 2. We assessed the role of Catecol-O-methyltransferase(COMT) genotype in a functional Magnetic Resonance Imaging (fMRI) event related study which gauged the effects of cognitive control on various conditions involving interference in the so called flanker task. 3. We developed a carefully matched set of verbal fluency tasks to examine the relation between semantic processing, thought disorder, and neurophysiology in schizophrenia using PET CBF (Positron Emission Tomography Cerebral Blood Flow) methods. We found an area in inferior prefrontal cortex (PFC) that was more activated in semantic fluency and correlated with a classic symptom of schizophrenia -- thought disorder. 4. We are using a novel updating task which allows the amount of "updating" to be varied parametrically by demanding operations on single or multiple frames within each trial. This technique will allow us to examine whether there is an interaction between load and delay in the dorsolateral prefrontal cortex and how and whether such interactions may engage different subdivisions within the prefrontal cortex.

我们已经开发了各种任务来激活功能性神经成像研究中的感兴趣区域。 1.为了研究情景记忆功能中回忆和熟悉之间的区别，我们开发了一个任务，使用视觉场景，可靠地诱导熟悉为基础的控制错误。 2.我们评估了儿茶酚-O-甲基转移酶（COMT）基因型在功能性磁共振成像（fMRI）事件相关研究中的作用，该研究评估了认知控制对涉及所谓侧翼任务干扰的各种条件的影响。 3.我们开发了一套精心匹配的语言流畅性任务，以研究语义处理，思维障碍，精神分裂症的神经生理学之间的关系，使用PET CBF（正电子发射断层扫描脑血流）的方法。我们发现，下前额叶皮层（PFC）中的一个区域在语义流畅性方面更活跃，并且与精神分裂症的一个典型症状-思维障碍有关。 4.我们正在使用一种新的更新任务，它允许“更新”的量是不同的参数，要求在每个审判中的单个或多个帧的操作。这项技术将使我们能够检查是否有负荷和延迟之间的相互作用，在背外侧前额叶皮层，以及如何以及是否这种相互作用可能涉及不同的细分在前额叶皮层。