Development Of Cognitive Activation Tasks For Functional

我们已经开发了各种任务来激活功能神经成像研究中的感兴趣区域。1.为了考察情景记忆的加工水平，我们设计了一系列或再认记忆任务。我们还特别注意了不涉及主动加工的控制任务的发展，以便更好地观察海马区的激活。结果表明，在编码和提取过程中，类似的区域被激活，包括额前皮质。在ANA ROI分析中获得了海马区的激活。2.我们评估了COMT基因在一项功能磁共振研究中的作用，该研究评估了苯丙胺对皮质效率的影响。与倒U形功能一致的是，正常受试者的低多巴胺能张力(Val基因型)改善了额叶皮质加工，而MET基因型(高多巴胺能张力)的受试者在高工作记忆负荷下表现出较低的皮质效率。3.我们开发了一套精心匹配的词汇流畅性任务，使用PET CBF方法考察了精神分裂症患者的语义加工、思维障碍和神经生理学之间的关系。我们发现，下前额叶皮质的一个区域更加活跃，语义不流畅，与精神分裂症的典型症状--思维障碍--相关。

We have developed a variety of tasks to activate regions of interest in functional neuroimaging studies. 1. To examine the levels of processing account of episodic memory we devised a series or recognition memory tasks. We also paid special attention to the development of a control task that would not involve active processing so as to better observe hippocampal activation. Results indicate similar regions, including prefrotnal cortex, were activated during encoding and retrieval. Hippocampal activation was obtained in ana ROI aanalysis. 2. We assessed the role of COMT genotype in an fMRI study which gauged the effects of amphetamine on cortical efficiency. Sonsistent with an inverted u-shaped function, normal subjecs woith low dopaminergic tone (val genotype) improved frontal ortical processing, while subjects with the met genotype (high dopaminergic tone) showed diminsished cortical efficiency at high working memory loads. 3. We developed a carefully matched set of verbal fluency tasks to examine the relation between semantic processing, thought disorder, and neurophysiology in schizophrenia using PET CBF methods. We und an area in inferior prefrontal cortex that was more activated insemantic fluency and correlated with a classic symptom of schizophrenia -- thought disorder.