Development Of Cognitive Activation Tasks For Functional

功能性认知激活任务的开发

• 批准号: 6541817
• 负责人: Terry E Goldberg
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6541817
• 关键词: brain imaging /visualization /scanning; brain mapping; brain metabolism; cerebellum; clinical research; cognition; frontal lobe /cortex; functional magnetic resonance imaging; human subject; memory; neural information processing; neuropsychological tests; positron emission tomography; schizophrenia; technology /technique development; verbal behavior

We have developed a variety of tasks to activate regions of interest in functional neuroimaging studies. 1. To examine the levels of processing account of episodic memory we devised a series or recognition memory tasks. We also paid special attention to the development of a control task that would not involve active processing so as to better observe hippocampal activation. Preliminary results indicate marked prefrontal cortical activations during higher level encoding and hippocampal activations during encoding and retrieva. 2. We developed a Continuous Performance Test of attention and encoding to be used in event related fMRI. While behavioral deficits have been widely reported in schizophrenic patients, the neural substrate of this task has yet to be elucidated. Toward this end we degraded stimuli and used only the letters x and y so each individual trial in an event related paradigm was informative. 3. We developed a carefully matched set of verbal fluency tasks to examine the relation between semantic processing, thought disorder, and neurophysiology in schizophrenia using PET CBF methods. We are also using a semantic processing task in fMRI to determine the physiologic concomitants of repetition priming versus conceptual priming in order to ascertain whether semantic access is automatic and if the two tasks involve similar functional neuroanatomies.

我们已经开发了各种任务来激活功能性神经成像研究中的感兴趣区域。1.本研究设计了一系列再认记忆任务，以考察情景记忆加工的水平。我们还特别关注了不涉及主动处理的控制任务的开发，以便更好地观察海马激活。初步结果表明，显着的前额叶皮层激活在较高水平的编码和海马激活在编码和检索。2.我们开发了一个连续的性能测试的注意和编码用于事件相关的功能磁共振成像。虽然精神分裂症患者的行为缺陷已被广泛报道，但这项任务的神经基质尚未阐明。为了达到这个目的，我们降低了刺激，只使用字母x和y，所以在一个事件相关的范例中，每个单独的试验都是信息丰富的。3.我们开发了一套精心匹配的语言流畅性任务，以探讨语义加工，思维障碍，精神分裂症的神经生理学之间的关系，使用PET CBF方法。我们还使用功能磁共振成像中的语义处理任务来确定重复启动与概念启动的生理伴随物，以确定语义访问是否是自动的，以及这两项任务是否涉及相似的功能神经解剖学。