Development Of Cognitive Activation Tasks For Functional

我们已经开发了各种任务来激活功能性神经成像研究中的感兴趣区域。 1.为了研究情景记忆功能中回忆和熟悉之间的区别，我们开发了一个任务，使用视觉场景，可靠地诱导熟悉为基础的控制错误。 2.我们评估了COMT基因型在fMRI事件相关研究中的作用，该研究评估了认知控制对涉及所谓侧翼任务干扰的各种条件的影响。 3.我们开发了一套精心匹配的语言流畅性任务，以探讨语义加工，思维障碍，精神分裂症的神经生理学之间的关系，使用PET CBF方法。我们发现，在下前额皮质的一个区域，在语义流畅性方面更活跃，并且与精神分裂症的一个典型症状--思维障碍有关。

We have developed a variety of tasks to activate regions of interest in functional neuroimaging studies. 1. To examine the distinction between recall and familiarity in episodic memory function we have developed a task using visual scenes that reliably induces familiarity based errors in controls. 2. We assessed the role of COMT genotype in an fMRI event related study which gauged the effects of cogntive control on various conditions involving interference in the so called flanker task. 3. We developed a carefully matched set of verbal fluency tasks to examine the relation between semantic processing, thought disorder, and neurophysiology in schizophrenia using PET CBF methods. We found an area in inferior prefrontal cortex that was more activated in semantic fluency and correlated with a classic symptom of schizophrenia -- thought disorder.