Development Of Cognitive Activation Tasks For Functional

功能性认知激活任务的开发

• 批准号: 6823934
• 负责人: Terry E Goldberg
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6823934
• 关键词: brain imaging /visualization /scanning; brain mapping; brain metabolism; cerebellum; clinical research; cognition; frontal lobe /cortex; functional magnetic resonance imaging; genotype; human subject; memory; neural information processing; neurophysiology; neuropsychological tests; positron emission tomography; schizophrenia; technology /technique development; verbal behavior

We have developed a variety of tasks to activate regions of interest in functional neuroimaging studies. 1. To examine the distinction between recall and familiarity in episodic memory function we have developed a task using visual scenes that reliably induces familiarity based errors in controls. 2. We assessed the role of COMT genotype in an fMRI event related study which gauged the effects of cogntive control on various conditions involving interference in the so called flanker task. 3. We developed a carefully matched set of verbal fluency tasks to examine the relation between semantic processing, thought disorder, and neurophysiology in schizophrenia using PET CBF methods. We found an area in inferior prefrontal cortex that was more activated in semantic fluency and correlated with a classic symptom of schizophrenia -- thought disorder.

我们开发了多种任务来激活功能神经影像研究中感兴趣的区域。 1. 为了检查情景记忆功能中回忆和熟悉度之间的区别，我们开发了一项使用视觉场景的任务，该任务可靠地在控制中引发基于熟悉度的错误。 2. 我们评估了 COMT 基因型在一项 fMRI 事件相关研究中的作用，该研究衡量了认知控制对涉及所谓侧翼任务干扰的各种条件的影响。 3. 我们开发了一套精心匹配的言语流畅性任务，以使用 PET CBF 方法检查精神分裂症的语义处理、思维障碍和神经生理学之间的关系。我们发现前额叶下皮层的一个区域在语义流畅性方面更加活跃，并且与精神分裂症的典型症状——思维障碍相关。