Insulin Resistance in Hepatitis C Virus Infection

丙型肝炎病毒感染中的胰岛素抵抗

• 批准号: 6985019
• 负责人: Aymin Delgado Delgado
• 金额: $ 12.89万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6985019
• 关键词: adolescence (12-20); cell communication molecule; child (0-11); clinical research; collagen; complement; epidemiology; hepatitis C; hepatitis C virus; histopathology; human data; human subject; human tissue; inflammation; insulin sensitivity /resistance; pathologic process; tumor necrosis factor alpha

DESCRIPTION (provided by applicant): The Candidate: Dr. Delgado has demonstrated strong commitment to the development of a solid career as a physician scientist. She worked under Dr. Chung's supervision as a Clinical Resarch Fellow and is currently a junior faculty member of the GI/Nutrition Department at Children's Hospital Boston. Dr. Delgado recently demonstrated an independent association between hepatitis C virus (HCV) infection and insulin resistance (IR). She seeks to advance her preliminary observations and to gain the necessary skills to become an independent investigator. The Environment: The candidate will work under the direct supervision of Dr. Chung and Dr. Lencer who will serve as mentors. She will work in close collaboration with Dr. Jonas and will have additional support from Drs. Grinspoon and Nathan who will provide additional intellectual support for her project. The Children's Hospital of Boston and Harvard Medical School community are committed to providing a nurturing scientific environment. Dr. Delgado will have access to office space and resources, will be supported by a wealth of outstanding clincians and investigators, and will acquire additional formal training necessary for the development of her career goals. The Research: Preliminary data has demonstrated an association between hepatitis C virus (HCV) infection and insulin resistance (IR). IR is associated with significant cardiovascular risks and appears to accelarate fibrosis progression of HCV. However, a causal role for HCV in the induction of IR remains to be demonstrated and the pathogenetic processess that mediate this association are unknown. This proposal is intended to evaluate a causal role for HCV in the induction of IR in both adults and children. Furthermore, the role of inflammatory adipokines as mediators of HCV induced IR will be investigated. The long term objective of this proposal is to lay the foundation for future therapeutic strategies to not only improve IR in HCV-infected individuals but also reduce the progression of liver disease in HCV infection.

描述（由申请人提供）： 候选人：Delgado博士已经证明了作为一名医生科学家发展坚实职业生涯的坚定承诺。她在钟博士的监督下工作，担任临床研究员，目前是波士顿儿童医院GI/营养科的初级教员。Delgado博士最近证明了丙型肝炎病毒（HCV）感染和胰岛素抵抗（IR）之间的独立关联。她寻求推进她的初步意见，并获得必要的技能，成为一名独立的调查员。 环境：候选人将在Chung博士和Lencer博士的直接监督下工作，他们将担任导师。她将与Jonas博士密切合作，并将得到Grinspoon博士和Nathan博士的额外支持，他们将为她的项目提供额外的智力支持。波士顿儿童医院和哈佛医学院社区致力于提供一个培育科学的环境。Delgado博士将获得办公空间和资源，将得到大量优秀临床医生和研究人员的支持，并将获得发展其职业目标所需的额外正式培训。 研究：初步数据表明丙型肝炎病毒（HCV）感染与胰岛素抵抗（IR）之间存在关联。IR与显著的心血管风险相关，并且似乎加速HCV的纤维化进展。然而，HCV在诱导IR中的因果作用仍有待证实，介导这种关联的发病过程尚不清楚。本提案旨在评估HCV在成人和儿童IR诱导中的因果作用。此外，炎症性脂肪因子作为HCV诱导的IR的介质的作用将被研究。该提案的长期目标是为未来的治疗策略奠定基础，不仅改善HCV感染者的IR，而且减少HCV感染者肝脏疾病的进展。