EFFECT OF HEPATITIS C VIRUS ON INSULIN RESISTANCE IN CHILDREN

丙型肝炎病毒对儿童胰岛素抵抗的影响

• 批准号: 7380772
• 负责人: Aymin Delgado Delgado
• 金额: $ 0.3万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7380772
• 关键词: EFFECT; HEPATITIS; VIRUS; INSULIN; RESISTANCE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A. Specific Aims /Objectives A cohort of children with HCV infection and healthy controls matched for age, gender, body mass index (BMI), and Tanner stage will be studied to evaluate whether: 1) HCV infection is associated with IR in children 2) Clearance of HCV infection improves IR in children 3) HCV infection correlates with higher TNF-alpha and lower adiponectin levels and these, in turn, correlate with IR both cross-sectionally as well as longitudinally Through the above aims, the following hypotheses will be tested: 1) HCV infection is associated with IR in children 2) Clearance of HCV infection reduces IR in children 3) Inflammatory adipokines mediate the development of HCV-associated IR

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。A.具体目的/目的：研究年龄、性别、体重指数（BMI）和Tanner分期相匹配的HCV感染儿童和健康对照的队列，以评估是否：1) HCV感染与儿童IR相关2)清除HCV感染可改善儿童IR 3) HCV感染与较高的tnf - α和较低的脂联素水平相关，而这些水平反过来又与IR在横断面和纵向上相关。通过上述目的，将检验以下假设：1) HCV感染与儿童IR相关2)清除HCV感染可降低儿童IR 3)炎性脂肪因子介导HCV相关IR的发生