Insulin Resistance in Hepatitis C Virus Infection

丙型肝炎病毒感染中的胰岛素抵抗

• 批准号: 7493965
• 负责人: Aymin Delgado Delgado
• 金额: $ 12.89万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7493965
• 关键词: Adult; Age; Body mass index; Boston; Child; Cirrhosis; Clinical; Collaborations; Commit; Communities; Condition; Data; Development; Diabetes Mellitus; Environment; Faculty; Fibrosis; Foundations; Future; Gender; Goals; Hepatitis C; Hepatitis C Antiviral; Hepatitis C virus; High Prevalence; Histologic; Histopathology; Individual; Infection; Inflammatory; Insulin Resistance; Liver Cirrhosis; Liver diseases; Mediating; Mediator of activation protein; Mentors; Morbidity - disease rate; National Health and Nutrition Examination Survey; Participant; Patients; Pediatric Hospitals; Physicians; Process; Public Health; Reporting; Research; Research Personnel; Resources; Role; Scientist; Solid; Staging; Supervision; Testing; Therapeutic; Training; Tumor Necrosis Factor-alpha; Work; adipokines; adiponectin; cardiovascular risk factor; career; cohort; cytokine; design; improved; medical schools; member; nutrition; programs; skills

DESCRIPTION (provided by applicant): The Candidate: Dr. Delgado has demonstrated strong commitment to the development of a solid career as a physician scientist. She worked under Dr. Chung's supervision as a Clinical Resarch Fellow and is currently a junior faculty member of the GI/Nutrition Department at Children's Hospital Boston. Dr. Delgado recently demonstrated an independent association between hepatitis C virus (HCV) infection and insulin resistance (IR). She seeks to advance her preliminary observations and to gain the necessary skills to become an independent investigator. The Environment: The candidate will work under the direct supervision of Dr. Chung and Dr. Lencer who will serve as mentors. She will work in close collaboration with Dr. Jonas and will have additional support from Drs. Grinspoon and Nathan who will provide additional intellectual support for her project. The Children's Hospital of Boston and Harvard Medical School community are committed to providing a nurturing scientific environment. Dr. Delgado will have access to office space and resources, will be supported by a wealth of outstanding clincians and investigators, and will acquire additional formal training necessary for the development of her career goals. The Research: Preliminary data has demonstrated an association between hepatitis C virus (HCV) infection and insulin resistance (IR). IR is associated with significant cardiovascular risks and appears to accelarate fibrosis progression of HCV. However, a causal role for HCV in the induction of IR remains to be demonstrated and the pathogenetic processess that mediate this association are unknown. This proposal is intended to evaluate a causal role for HCV in the induction of IR in both adults and children. Furthermore, the role of inflammatory adipokines as mediators of HCV induced IR will be investigated. The long term objective of this proposal is to lay the foundation for future therapeutic strategies to not only improve IR in HCV-infected individuals but also reduce the progression of liver disease in HCV infection.

描述(由申请人提供)： 候选人：德尔加多博士表现出了坚定的决心，致力于作为一名内科科学家发展坚实的职业生涯。她在钟博士的指导下工作，担任临床研究员，目前是波士顿儿童医院胃肠/营养科的初级教员。Delgado博士最近证明了丙型肝炎病毒(丙型肝炎病毒)感染和胰岛素抵抗(IR)之间的独立联系。她寻求提高她的初步观察，并获得必要的技能，成为一名独立的调查员。 环境：候选人将在钟博士和兰瑟博士的直接监督下工作，他们将担任导师。她将与乔纳斯博士密切合作，并将得到格林斯普龙博士和内森博士的额外支持，他们将为她的项目提供额外的智力支持。波士顿儿童医院和哈佛医学院社区致力于提供一个有教养作用的科学环境。Delgado博士将获得办公空间和资源，将得到一大批杰出的临床医生和调查人员的支持，并将获得发展其职业目标所需的额外正式培训。 研究：初步数据表明丙型肝炎病毒(丙型肝炎病毒)感染和胰岛素抵抗(IR)之间存在关联。IR与显著的心血管风险相关，并且似乎加速了丙型肝炎的纤维化进展。然而，丙型肝炎病毒在诱导IR中的因果作用仍有待证实，调节这种联系的致病过程尚不清楚。这项建议旨在评估丙型肝炎病毒在成人和儿童诱导胰岛素抵抗中的因果作用。此外，还将研究炎性脂肪因子作为丙型肝炎病毒诱导的胰岛素抵抗的介体的作用。这项建议的长期目标是为未来的治疗策略奠定基础，不仅改善丙型肝炎病毒感染者的胰岛素抵抗，而且减少丙型肝炎病毒感染时肝脏疾病的进展。