Differential Gene Expression in Keloids
瘢痕疙瘩的差异基因表达
基本信息
- 批准号:6950018
- 负责人:
- 金额:$ 2.16万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2004
- 资助国家:美国
- 起止时间:2004-09-15 至 2009-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): Keloids represent an insidious disease process that afflicts primarily young, minority patients leaving them with disfigurement, and occasionally, disability. This research application seeks to address the observation that keloid-derived skin cells appear to have an aberrant genotypic response compared to normal-derived skin cells to stress in the form of serum stimulation and physical strain. This phenomenon will be examined by focusing on the differential transcriptional response of the TGF-beta2 gene to serum stimulation in keratinocytes. The three specific aims of this application are to determine the promoter elements responsible for this differential response, identify the signal transduction pathways mediating the response, and identify additional genes that may be coordinately regulated with TGF-beta2 and contributing to the keloid phenotype. In addition to answering important questions about keloid biology, this application will also serve !to provide the nit a support for the academic career of the Principal Investigator. He has demonstrated a long record of commitment to biomedical research and has chosen wound healing and surgery as the field he wishes to pursue. His initial goal is to establish a laboratory in wound healing that is fully supported through extramural funding. The long term goal of the Principal Investigator is to use the knowledge derived from his studies in wound healing to better understand the biology of skin. This information can then be translated into clinical applications through the treatment of chronic wounds or excessive scarring, and can also be used in tissue engineering to synthesize artificial skin that can be applied to clinical problems in reconstruction, including burns. A career development program is detailed that is designed to educate the Principal Investigator in the proper, ethical conduct of research. Plans have been developed to improve specific skills to promote his career development. These include experimental design, grantsmanship, interactions with the surgical and scientific community, and manuscript preparation and review. This project will be carried out under the tutelage of a highly successful Mentor at Stanford University Medical School. This is one of the leading biomedical research institutions in the nation, and it has implemented multiple programs aimed at improving translational medicine. The institution has every resource needed to carry out this project in addition to a number of experts in the field to provide advice.
描述(申请人提供):瘢痕疙瘩代表一种潜伏的疾病过程,主要困扰年轻的少数族裔患者,使他们毁容,有时甚至残疾。这项研究旨在解决以下观察结果:与正常来源的皮肤细胞相比,瘢痕疙瘩来源的皮肤细胞似乎对血清刺激和物理应变形式的应激具有异常的基因反应。这一现象将通过关注角质形成细胞中转化生长因子-β2基因对血清刺激的差异转录反应来检验。这项应用的三个具体目的是确定负责这种差异反应的启动子元件,确定介导反应的信号转导途径,以及确定可能与转化生长因子-β2协调调节的与瘢痕疙瘩表型有关的其他基因。除了回答有关瘢痕疙瘩生物学的重要问题外,该应用程序还将为NIT首席研究员的学术生涯提供支持。他展示了长期致力于生物医学研究的记录,并选择伤口愈合和手术作为他希望追求的领域。他最初的目标是建立一个由外部资金完全支持的伤口愈合实验室。首席研究员的长期目标是利用他在伤口愈合方面的研究所获得的知识,更好地了解皮肤的生物学。然后,这些信息可以通过治疗慢性伤口或过度疤痕转化为临床应用,也可以用于组织工程,合成人造皮肤,用于重建过程中的临床问题,包括烧伤。职业发展计划是详细的,旨在教育首席调查员在适当的,道德的研究行为。已经制定了提高特定技能的计划,以促进他的职业发展。这些包括实验设计、授权、与外科和科学界的互动,以及手稿的准备和审查。这个项目将在斯坦福大学医学院一位非常成功的导师的指导下进行。这是全国领先的生物医学研究机构之一,它实施了多个旨在改善转化医学的计划。除了该领域的一些专家提供咨询外,该机构拥有执行该项目所需的一切资源。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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GEORGE P YANG其他文献
GEORGE P YANG的其他文献
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{{ truncateString('GEORGE P YANG', 18)}}的其他基金
Identifying Approaches to Enhance Bone and Cartilage Regeneration
确定增强骨和软骨再生的方法
- 批准号:
9484099 - 财政年份:2017
- 资助金额:
$ 2.16万 - 项目类别:
Identifying Approaches to Enhance Bone and Cartilage Regeneration
确定增强骨和软骨再生的方法
- 批准号:
10409635 - 财政年份:2017
- 资助金额:
$ 2.16万 - 项目类别:
Identifying Approaches to Enhance Bone and Cartilage Regeneration
确定增强骨和软骨再生的方法
- 批准号:
9782099 - 财政年份:2017
- 资助金额:
$ 2.16万 - 项目类别:
Identifying Approaches to Enhance Bone and Cartilage Regeneration
确定增强骨和软骨再生的方法
- 批准号:
10045950 - 财政年份:2017
- 资助金额:
$ 2.16万 - 项目类别:
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