NIAMS Multidiciplinary Clinical Research Center in Cinc*

总体说明：（摘自申请）本提案 来自辛辛那提儿童医院医疗中心的研究人员的目标是 影响临床实践，因为它适用于最常见的风湿性关节炎， 儿童疾病。该提案也部分代表了竞争对手 更新中心现有的P60 MAMDC，并免费提供P30 辛辛那提风湿病核心中心今年早些时候提交的。是 据估计，美国有140，000 - 200，000名儿童患有风湿性关节炎， 疾病，其中许多，但不是全部，是自身免疫性的。主要疾病有 幼年类风湿性关节炎、系统性红斑狼疮、硬皮病和 青少年皮肌炎影响越来越大的是区域性疾病， 全身性肌肉骨骼疼痛综合征，其中纤维肌痛是 特别常见，频率似乎在增加， 重大管理问题。该中心的五个组成部分是： 与所有项目互动;依那西普在青少年中的试验 皮肌炎;青少年发病者心理状况的研究 纤维肌痛;定量T2显像;甲氨蝶呤 JRA中的药物基因组学。此外，还有一个行政单位， 将行使业务控制和行政监督的所有 通过一个执行委员会、两个咨询委员会和一个 社区董事会。短期和长期目标是 改善患有这些疾病的儿童的健康，并更好地确保 从童年和青春期到青年期的平稳过渡， 患有慢性风湿病的孩子

DESCRIPTION OF THE OVERALL PROGRAM: (Taken from the application) This proposal from the Children's Hospital Medical Center in Cincinnati has the goal of impacting a clinical practice as it is applied to the most common rheumatic diseases of childhood. This proposal also represents in part the competing renewal for the Centers existing P60 MAMDC and is complimentary to the P30 Cincinnati Rheumatic Diseases Core Center submitted earlier this year. It is estimated that 140,000-200,000 children within the United States have rheumatic disease, many, but not all, of which are autoimmune. The major diseases are juvenile rheumatoid arthritis, systemic lupus erythematosus, scleroderma and juvenile dermatomyositis. Of increasing impact are illnesses with regional and generalized musculoskeletal pain syndromes of which fibromyalgia is particularly common and appears to be increasing in frequency and can present a major management problem. The five components of the Center are: A methods core interacting with all projects; A trial of etanercept in juvenile dermatomyositis; A study of psychological status in juvenile onset fibromyalgia; An imaging study using quantitative T2 mapping JRA; Methotrexate pharmacogenomics in JRA. In addition, there is an administrative unit which will exercise operational control and administrative oversight of all the projects through an executive committee, two Advisory Boards and a Community-Based Board of Directors. The short- and long-term goals are to improve the health of children with these conditions and to better ensure a smooth transition from childhood and adolescence through to young adulthood for the child with a chronic rheumatic disease.