Core B: Pediatric Rheumatology Informatics (Informatics Core)

儿科风湿病信息学核心是P30风湿病核心的资助组成部分 中心和一个主要的贡献者，过去的成功，政治行动计划。该核心提供生物医学 信息学专业知识和基础设施的辛辛那提风湿病核心中心研究基地， 辛辛那提儿童医院医疗中心辛辛纳菲儿童研究基金会和 诺丁汉大学医学院。由于持续需要大量的微阵列数据 管理和分析的支持，由拟议的政治行动计划，我们建议限制资金， 补充信息核心。补充的目的是提供足够的 生物信息学基础设施、专门知识和具体数据管理和分析的实际协助 四个项目的需求。核心将为各个项目提供量身定制的分析支持，并执行 整合整个项目中生成的所有数据的分析。核心将采用标准化的，国家- 管理和分析微阵列数据的最先进的协议，并开发创新的统计学 用于构建和验证预测转录签名的学习方法。总之，核心 将通过整合当前的相关方法， 生物学和临床见解。该核心还将促进科学工作者有意义地获取数据， 通过开发新的JIA基因组学数据门户网站（http：//www.example.com）， 根据需要为研究项目提供生物统计支持。核心的三个目标是：1）提供研究 项目与全面的生物信息学支持的管理，分析和解释的DNA 2）开发JIA基因组学数据门户网站（http：//www.example.com）作为社区 资源，用于有意义地访问由POI项目产生的基因组学数据，并提供基因组学 数据"背景"，以便对这些数据进行有意义的解释和分析;以及3）应用创新的统计方法， JIA基因组学数据的综合分析方法，以促进在 构建预测性转录签名。 相关性（参见说明）： 信息学核心将为管理、分析和解释提供全面的支持， 本计划项目中每个项目产生的基因表达数据。信息学核心将 还开发了一个"JIA基因组学数据门户"，这将是一个可供研究界访问的资源， 核心将使用分析基因表达数据的创新方法来了解疾病 JIA的分子机制，并开发用于临床预测结果的分子工具。

The Pediatric Rheumatology Informatics Core is a funded component of a P30 Rheumafic Disease Core Center and a major contributor to the past success of the POl program. This core provides biomedical informafics expertise and infrastructure to the Cincinnati Rheumatic Diseases Core Center Research Base at the Cincinnafi Children's Research Foundation of Cincinnati Children's Hospital Medical Center, and the University of Cincinnafi College of Medicine. Because of the continued need for extensive microarray data management and analysis support by the proposed POl program, we are proposing to confinue to fund a supplement to the Informafics Core. The purpose of the supplement will be to provide adequate bioinformatics infrastructure, expertise and hands on assistance for specific data management and analysis needs of the 4 POl projects. The core will provide tailored analysis support to individual projects and perform integrafive analyses of all data generated throughout the project. The Core will employ standardized, state- of-the-art protocols for management and analysis of microarray data and develop innovafive stafistical learning approaches for constructing and validating predicfive transcripfional signatures. Altogether, the Core will facilitate the use of optimal data analysis procedures by integrating current relevant methodological, biological and clinical insights. The core will also facilitate the meaningful access to data by the scientific community through the development of new JIA Genomics Data Portal (http://JIAGenomics.org), and provide biostatistical support to research projects as needed. The three aims of the core are: 1) To provide research projects with the comprehensive Bioinformatics support for management, analysis and interpretation of DNA microarray data; 2) To develop the JIA genomics data portal (http://JlAGenomics.org) as the community resource for meaningful access to genomics data produced by POl projects, and to provide the genomics data "context" for meaningful interpretation and analysis of this data; and 3) To apply innovative stafisfical methods for integrated analysis of JIA genomics data to facilitate the use of mechanistic insights in constructing predictive transcriptional signatures. RELEVANCE (See instructions): The Informatics Core will provide comprehensive support for management, analysis and interpretafion of gene expression data generated by each of the projects in this Program Project. The Informatics Core will also develop a "JIA genomics data portal" that will be an accessible resource for the research community, and the Core will use innovative methods of analyzing gene expression data to understand disease mechanisms in JIA and develop molecular tools for clinical use in predicfing outcomes.